Modification of the myostatin and nitric oxide signalling pathways as treatments for Duchenne Muscular Dystrophy
PhD Thesis
Title | Modification of the myostatin and nitric oxide signalling pathways as treatments for Duchenne Muscular Dystrophy |
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Type | PhD Thesis |
Authors | |
Author | Marrett, Garth |
Supervisor | Brown, Lindsay |
Institution of Origin | University of Southern Queensland |
Qualification Name | Doctor of Philosophy |
Number of Pages | 240 |
Year | 2012 |
Abstract | Duchenne muscular dystrophy (DMD) is a fatal X-linked disease affecting 1 in 3500 live male births that arises from faulty production of the sub-sarcolemmal protein, dystrophin. Pathology associated with dystrophin deficiency is complex but primarily characterised by progressive muscular atrophy and fibrosis resulting from cycles of damage and repair. Four separate studies in this dissertation used murine models of DMD (mdx mice) to examine the effects of myostatin absence and modulation of the NO-cGMP pathway on muscle function and fibrosis. |
Keywords | duchenne muscular dystrophy; dystrophin deficiency; signal pathways; myostatin absence |
ANZSRC Field of Research 2020 | 320899. Medical physiology not elsewhere classified |
Byline Affiliations | Faculty of Sciences |
https://research.usq.edu.au/item/q1y7w/modification-of-the-myostatin-and-nitric-oxide-signalling-pathways-as-treatments-for-duchenne-muscular-dystrophy
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