Effectiveness of a hydrogel dressing as an analgesic adjunct to first aid for the treatment of acute paediatric thermal burn injuries: study protocol for a randomised controlled trial

Article


Holbert, Maleea D., Griffin, Bronwyn R., McPhail, Steven M., Ware, Robert S., Foster, Kelly, Bertoni, Demi C. and Kimble, Roy M.. 2019. "Effectiveness of a hydrogel dressing as an analgesic adjunct to first aid for the treatment of acute paediatric thermal burn injuries: study protocol for a randomised controlled trial." Trials. 20 (1), pp. 1-13. https://doi.org/10.1186/s13063-018-3057-x
Article Title

Effectiveness of a hydrogel dressing as an analgesic adjunct to first aid for the treatment of acute paediatric thermal burn injuries: study protocol for a randomised controlled trial

ERA Journal ID35155
Article CategoryArticle
AuthorsHolbert, Maleea D. (Author), Griffin, Bronwyn R. (Author), McPhail, Steven M. (Author), Ware, Robert S. (Author), Foster, Kelly (Author), Bertoni, Demi C. (Author) and Kimble, Roy M. (Author)
Journal TitleTrials
Journal Citation20 (1), pp. 1-13
Article Number13
Number of Pages13
Year2019
Place of PublicationUnited Kingdom
ISSN1745-6215
Digital Object Identifier (DOI)https://doi.org/10.1186/s13063-018-3057-x
Web Address (URL)https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-3057-x
Abstract

Background: Burns are a painful and traumatic experience, particularly in children. Reduced pain and anxiety positively influences re-epithelialisation rates in paediatric burn patients, however current literature fails to fully explain the effects of pain and anxiety and their links with wound healing. This study will determine if Burnaid® hydrogel dressing is an effective treatment for reducing pain in the acute period of a burn injury. It is hypothesised that a reduction in pain will then improve re-epithelialisation time in comparison to plastic wrap, which is standard practice at our institution — a metropolitan tertiary paediatric hospital located in Brisbane, Australia.

Methods/design: A randomised controlled trial will be conducted to assess the effectiveness of Burnaid® as an analgesic adjunct to cold running water first aid for the treatment of paediatric burns. Participants will include children aged between 0 and 16years with an acute thermal burn injury (total burn surface area <20%) presenting to the Department of Emergency within 24h of the burn occurring. Participants will be randomised into one of two groups: (1) Burnaid® hydrogel (intervention arm) or (2) plastic wrap (control arm). Participants will also be stratified into one of two groups based on factors that influence pain intensity: (1) high pain risk or (2) low pain risk. High pain risk factors include foot burns, hot coal/ash/fire pit burns, burn area greater than 5%, and circumferential burns. The primary outcome is the intervention’s effect on reducing acute pain. Secondary outcomes include days to re-epithelialisation, pulse rate, temperature, salivary cortisol and α-amylase, anxiety, and cost-effectiveness. Sample size calculations have shown that 36 participants will be recruited into each group.

Discussion: This study will provide comprehensive data on the analgesic properties of Burnaid® as an adjunct to first aid for the treatment of acute paediatric thermal burns. If the intervention is effective in reducing pain, Burnaid® will be integrated as standard practice within the hospital’s Department of Emergency. This study replicates a real-world scenario in order to identify clinically significant analgesic and wound-healing effects.

Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12617001274369. Prospectively registered on 5 Sept 2017.

Keywordspaediatric, burns, first aid, hydrogel, Burnaid®, re-epithelialisation, analgesia, dressing, randomised controlled trial, pain
ANZSRC Field of Research 2020321399. Paediatrics not elsewhere classified
Byline AffiliationsUniversity of Queensland
Queensland University of Technology
Griffith University
Department of Health, Queensland
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q515q/effectiveness-of-a-hydrogel-dressing-as-an-analgesic-adjunct-to-first-aid-for-the-treatment-of-acute-paediatric-thermal-burn-injuries-study-protocol-for-a-randomised-controlled-trial

Download files


Published Version
Burns Paper (002).pdf
License: CC BY 4.0
File access level: Anyone

  • 229
    total views
  • 144
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

A mathematical framework for regional hospital case mix planning and capacity appraisal
Burdett, Robert L., Corry, Paul, Yarlagadda, Prasad, Cook, David, Birgan, Sean and McPhail, Steven M. 2023. "A mathematical framework for regional hospital case mix planning and capacity appraisal." Operations Research Perspectives. 10, pp. 1-23. https://doi.org/10.1016/j.orp.2022.100261
Safety and efficacy of midline catheters versus peripheral intravenous catheters: A pilot randomized controlled trial
Marsh, Nicole, Larsen, Emily N., O'Brien, Catherine, Ware, Robert S., Kleidon, Tricia M., Groom, Peter, Hewer, Barbara, Alexandrou, Evan, Flynn, Julie, Woollett, Kaylene and Rickard, Claire M.. 2022. "Safety and efficacy of midline catheters versus peripheral intravenous catheters: A pilot randomized controlled trial." International Journal of Nursing Practice. 29 (2), pp. 1-11. https://doi.org/10.1111/ijn.13110
Bolus Versus Continuous Nasogastric Feeds for Infants With Bronchiolitis: A Randomized Trial
Courtney, Alyssa, Bernard, Anne, Burgess, Scott, Davies, Katie, Foster, Kelly, Kapoor, Vishal, Levitt, David and Sly, Peter. 2022. "Bolus Versus Continuous Nasogastric Feeds for Infants With Bronchiolitis: A Randomized Trial." Hospital Pediatrics. 12 (1), pp. 1-8. https://doi.org/10.1542/hpeds.2020-005702
FAST CBT for pediatric OCD: A multiple-baseline controlled pilot trial of parent training in exposure and response prevention delivered via telehealth
Farrell, Lara J., de Diaz, Natalja A. Nabinger, Mathieu, Sharna, McKenzie, Matthew L., Miyamoto, Taka, Donovan, Caroline L., Waters, Allison M., March, Sonja, Bothma, Nicole, Kroon, Rianca, Simcock, Gabrielle, Ware, Robert S., Selle, Robert R., Storch, Eric A. and Ollendick, Thomas. 2022. "FAST CBT for pediatric OCD: A multiple-baseline controlled pilot trial of parent training in exposure and response prevention delivered via telehealth." Frontiers in Psychology. 13. https://doi.org/10.3389/fpsyg.2022.1009735
Bolus versus continuous nasogastric feeding for infants hospitalised with bronchiolitis: a randomised clinical trial
Courtney, Alyssa, Bernard, Anne, Burgess, Scott, Davies, Katie, Foster, Kelly, Kapoor, Vishal, Levitt, David and Sly, Peter D.. 2021. "Bolus versus continuous nasogastric feeding for infants hospitalised with bronchiolitis: a randomised clinical trial." Journal of Paediatrics and Child Health. 57 (Suppl. 1). https://doi.org/10.1111/jpc.15477
Variation in CT use for paediatric head injuries across different types of emergency departments in Australia and New Zealand
Wilson, Catherine L., Tavender, Emma J., Phillips, Natalie T., Hearps, Stephen J. C., Foster, Kelly, O’Brien, Sharon L., Borland, Meredith L., Watkins, Gina O., McLeod, Lorna, Putland, Mark, Priestley, Stephen, Brabyn, Christine, Ballard, Dustin W., Craig, Simon, Dalziel, Stuart R., Oakley, Ed and Babl, Franz E.. 2020. "Variation in CT use for paediatric head injuries across different types of emergency departments in Australia and New Zealand." Emergency Medicine Journal. 37 (11), pp. 686-689. https://doi.org/10.1136/emermed-2020-209719
Response to Letter to the Editor: Addressing concerns from a recent randomised controlled trial protocol of two acute burn dressings
Holbert, Maleea D., Griffin, Bronwyn R., Ware, Robert S., Foster, Kelly and Kimble, Roy M.. 2020. "Response to Letter to the Editor: Addressing concerns from a recent randomised controlled trial protocol of two acute burn dressings." Burns. 46 (1), pp. 234-235. https://doi.org/10.1016/j.burns.2019.10.029
Randomized controlled trial of a web-based multi-modal therapy program for executive functioning in children and adolescents with unilateral cerebral palsy
Piovesana, Adina M., Ross, Stephanie, Lloyd, Owen, Whittingham, Koa, Ziviani, Jenny, Ware, Robert S. and Boyd, Roslyn N.. 2017. "Randomized controlled trial of a web-based multi-modal therapy program for executive functioning in children and adolescents with unilateral cerebral palsy." Disability and Rehabilitation. 39 (20), pp. 2021-2028. https://doi.org/10.1080/09638288.2016.1213899
Transnasal Humidified Rapid Insufflation Ventilatory Exchange in children requiring emergent intubation (Kids THRIVE): a protocol for a randomised controlled trial
George, Shane, Humphreys, Susan, Williams, Tara, Gelbart, Ben, Chavan, Arjun, Rasmussen, Katie, Ganeshalingham, Anusha, Erickson, Simon, Ganu, Subodh Suhas, Singhal, Nitesh, Foster, Kelly, Gannon, Brenda, Gibbons, Kristen, Schlapbach, Luregn, Festa, Marino, Dalziel, Stuart and Schibler, Andreas. 2019. "Transnasal Humidified Rapid Insufflation Ventilatory Exchange in children requiring emergent intubation (Kids THRIVE): a protocol for a randomised controlled trial." BMJ Open. 9 (2), pp. 1-8. https://doi.org/10.1136/bmjopen-2018-025997
A Queensland research support network in emergency healthcare: collaborating to build the research capacity of more clinicians in more locations
Sweeny, Amy, van den Berg, Lisa, Hocking, Julia, Renaud, Julia, Young, Sharleen, Henshaw, Richard, Foster, Kelly and Howell, Tegwen. 2019. "A Queensland research support network in emergency healthcare: collaborating to build the research capacity of more clinicians in more locations." Journal of Health, Organization and Management. 33 (1), pp. 93-109. https://doi.org/10.1108/JHOM-02-2018-0068
Job strain and psychological distress in office workers: The role of coping
Jun, Deokhoon, O'Leary, Shaun, McPhail, Steven M. and Johnston, Venerina. 2019. "Job strain and psychological distress in office workers: The role of coping." Work. 64 (1), pp. 55-65. https://doi.org/10.3233/WOR-192968
A randomised controlled trial of a web-based multi-modal therapy program to improve executive functioning in children and adolescents with acquired brain injury
Piovesana, Adina, Ross, Stephanie, Lloyd, Owen, Whittingham, Koa, Ziviani, Jenny, Ware, Robert S., McKinlay, Lynne and Boyd, Roslyn N.. 2017. "A randomised controlled trial of a web-based multi-modal therapy program to improve executive functioning in children and adolescents with acquired brain injury." Clinical Rehabilitation. 31 (10), pp. 1351-1363. https://doi.org/10.1177/0269215517695373
Stability of executive functioning measures in 8–17-year-old children with unilateral cerebral palsy
Piovesana, Adina M., Ross, Stephanie, Whittingham, Koa, Ware, Robert S. and Boyd, Roslyn N.. 2015. "Stability of executive functioning measures in 8–17-year-old children with unilateral cerebral palsy." The Clinical Neuropsychologist. 29 (1), pp. 133-149. https://doi.org/10.1080/13854046.2014.999125
Mitii™ ABI: study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an acquired brain injury (ABI)
Boyd, Roslyn B, Baque, Emmah, Piovesana, Adina, Ross, Stephanie, Ziviani, Jenny, Sakzewski, Leanne, Barber, Lee, Lloyd, Owen, McKinlay, Lynne, Whittingham, Koa, Smith, Anthony C., Rose, Stephen, Fiori, Simona, Cunnington, Ross, Ware, Robert, Lewis, Melinda, Comans, Tracy A. and Scuffham, Paul. A. 2015. "Mitii™ ABI: study protocol of a randomised controlled trial of a web-based multi-modal training program for children and adolescents with an acquired brain injury (ABI)." BMC Neurology. 15 (140). https://doi.org/10.1186/s12883-015-0381-6
Infant feeding knowledge, attitudes,and beliefs predict antenatal intention among first-time mothers in Queensland
Newby, Ruth, Brodribb, Wendy, Ware, Robert and Davies, Peter S. W.. 2014. "Infant feeding knowledge, attitudes,and beliefs predict antenatal intention among first-time mothers in Queensland." Breastfeeding Medicine. 9 (5), pp. 266-272. https://doi.org/10.1089/bfm.2014.0012
Population pharmacokinetics of phenytoin in critically ill children
Hennig, Stefanie, Norris, Ross, Tu, Quyen, van Breda, Karin, Riney, Kate, Foster, Kelly, Lister, Bruce and Charles, Bruce. 2014. "Population pharmacokinetics of phenytoin in critically ill children." The Journal of Clinical Pharmacology. 55 (3), pp. 355-364. https://doi.org/10.1002/jcph.417
Reduced intubation rates for infants after introduction of high-flow nasal prong oxygen delivery
Schibler, A., Pham, T., Dunster, K.R., Foster, K., Barlow, A., Gibbons, K. and Hough, J.L.. 2011. "Reduced intubation rates for infants after introduction of high-flow nasal prong oxygen delivery." Intensive Care Medicine. 37, pp. 847-852. https://doi.org/10.1007/s00134-011-2177-5
Controversies of prophylactic hypothermia and the emerging use of brain tissue oxygen tension monitoring and decompressive craniectomy in traumatic brain-injured children
Foster, Kelly, Stocker, C. and Schibler, A.. 2010. "Controversies of prophylactic hypothermia and the emerging use of brain tissue oxygen tension monitoring and decompressive craniectomy in traumatic brain-injured children." Australian Critical Care. 23 (1), pp. 4-11. https://doi.org/10.1016/j.aucc.2009.11.001