A mathematical model of Chlamydial infection incorporating movement of Chlamydial particles

Article

Mallet, D. G., Bagher-Oskouei, M., Farr, A. C., Simpson, D. P. and Sutton, K. J.. 2013. "A mathematical model of Chlamydial infection incorporating movement of Chlamydial particles." Bulletin of Mathematical Biology. 75 (11), pp. 2257-2270. https://doi.org/10.1007/s11538-013-9891-9
Article Title

A mathematical model of Chlamydial infection incorporating movement of Chlamydial particles

ERA Journal ID924
Article CategoryArticle
AuthorsMallet, D. G. (Author), Bagher-Oskouei, M. (Author), Farr, A. C. (Author), Simpson, D. P. (Author) and Sutton, K. J. (Author)
Journal TitleBulletin of Mathematical Biology
Journal Citation75 (11), pp. 2257-2270
Number of Pages14
Year2013
Place of PublicationNew York
ISSN0092-8240
1522-9602
Digital Object Identifier (DOI)https://doi.org/10.1007/s11538-013-9891-9
Web Address (URL)https://link.springer.com/article/10.1007%2Fs11538-013-9891-9
Abstract

We present a spatiotemporal mathematical model of chlamydial infection, host immune response, and movement of infectious particles. The resulting partial differential equations model both the dynamics of the infection and changes in infection profile observed spatially along the length of the host genital tract. This model advances previous Chlamydia modelling by incorporating spatial change. Numerical solutions and model analysis are carried out, and we present a hypothesis regarding the potential for treatment and prevention of infection by increasing chlamydial particle motility.

Keywordschlamydia trachomatis, partial differential equation, infectious diseases, treatment
ANZSRC Field of Research 2020490102. Biological mathematics
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Byline AffiliationsQueensland University of Technology
Medical College of Wisconsin, United States
Norwegian University of Science and Technology, Norway
University of Nottingham, United Kingdom
Institution of OriginUniversity of Southern Queensland
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