Prevalence of Hepatitis B Virus Infection in Shenzhen, China, 2015–2018

Article


Tao, Jian, Zhang, Weimin, Yue, Huakui, Zhu, Guohun, Wu, Wenyuan, Gong, Wenbo, Fang, Honghui, He, Guirong, Hu, Xiaoyun, Zhao, Hongyue and Liu, Aiqin. 2019. "Prevalence of Hepatitis B Virus Infection in Shenzhen, China, 2015–2018 ." Scientific Reports. 9. https://doi.org/10.1038/s41598-019-50173-5
Article Title

Prevalence of Hepatitis B Virus Infection in Shenzhen, China, 2015–2018

ERA Journal ID201487
Article CategoryArticle
AuthorsTao, Jian, Zhang, Weimin, Yue, Huakui, Zhu, Guohun, Wu, Wenyuan, Gong, Wenbo, Fang, Honghui, He, Guirong, Hu, Xiaoyun, Zhao, Hongyue and Liu, Aiqin
Journal TitleScientific Reports
Journal Citation9
Article Number13948
Number of Pages9
Year26 Sep 2019
PublisherNature Publishing Group
Place of PublicationUnited Kingdom
ISSN2045-2322
Digital Object Identifier (DOI)https://doi.org/10.1038/s41598-019-50173-5
Web Address (URL)https://www.nature.com/articles/s41598-019-50173-5
Abstract

China has nearly 10% of the general HBV carrier population in the world; this infection is the most common cause of chronic liver disease. Understanding HBV epidemiology is essential for future infection control, evaluation, and treatment. This study determined the prevalence of HBV infection in Shenzhen by serological testing and analysis in 282,166 HBV screening cases for the following: HBcAb, indicative of previous HBV infection; HBsAg, indicative of chronic (current) infection; HBsAb, indicative of immunity from vaccination; and 34,368 HBV etiological screening cases for HBV-DNA, indicative of virus carriage, in which 1,204 cases were genotyped and mutation analyzed for drug-resistance evaluation. Shenzhen was a highly endemic area of HBV throughout the study period (prevalence 9.69%). HBV infections were almost entirely in the 20 and older age groups with a male-to-female ratio of 1.16:1 which is approximately the same as the male-to-female ratio of the general population in China. However, only 71.25% of the general population retained HBV immune protection. Genotype B and C were identified as the most common agents; recombinant B/C and B/D also existed; some cases, however, could not be genotyped. NAs resistant mutation occurrence patterns were multitudinous; single mutation patterns of rtM204I/V and rtL180M occurrences accounted for majority, followed by the combinational mutation pattern L180M + M204I/V. Drug-resistance was prevalent, mainly occurring in the cross resistance patterns LAM + LdT and LAM + LdT + ETV, and significantly more critical in males. These results demonstrate that all people free from HBV infection should obtain injections of the vaccine or booster shots, and conventional virologic detection in a clinical laboratory center should incorporate genotype and mutation alongside the serological factors for etiology and develop better classification methods, such as sequencing.

KeywordsHepatitis B
ANZSRC Field of Research 20204202. Epidemiology
Byline AffiliationsJinan University, China
University of Queensland
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