The effects of oclacitinib treatment on antimicrobial usage in allergic dogs in primary practice: an Australia wide case-control study

Article


Rynhoud, Hester, Croton, Catriona, Henry, Grace, Meler, Erika, Gibson, Justine S. and Soares Magalhaes, Ricardo J.. 2022. "The effects of oclacitinib treatment on antimicrobial usage in allergic dogs in primary practice: an Australia wide case-control study." BMC Veterinary Research. 18 (1). https://doi.org/10.1186/s12917-022-03255-y
Article Title

The effects of oclacitinib treatment on antimicrobial usage in allergic dogs in primary practice: an Australia wide case-control study

ERA Journal ID5592
Article CategoryArticle
AuthorsRynhoud, Hester, Croton, Catriona, Henry, Grace, Meler, Erika, Gibson, Justine S. and Soares Magalhaes, Ricardo J.
Journal TitleBMC Veterinary Research
Journal Citation18 (1)
Article Number151
Number of Pages9
Year2022
PublisherBioMed Central Ltd.
Place of PublicationUnited Kingdom
ISSN1746-6148
Digital Object Identifier (DOI)https://doi.org/10.1186/s12917-022-03255-y
Web Address (URL)https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-022-03255-y
Abstract

Background
Canine allergic dermatitis is a common diagnosis in veterinary practices which can lead to secondary infections requiring treatment with antimicrobials. A previous study suggested that dogs treated with oclacitinib in an Australian referral hospital required fewer courses of antimicrobial therapy compared to dogs receiving other anti-pruritic treatments. This study aimed to quantify the effect of oclacitinib treatment on the use of antimicrobials and other therapies in general practice veterinary clinics across Australia. A retrospective case-controlled review of patient records was designed to investigate the number of courses of antimicrobials and other therapies in dogs that received oclacitinib (Apoquel®), compared with those who received an anti-pruritic treatment that was not oclacitinib.

Results
The target population included canine patients with a presumptive diagnosis of allergic dermatitis presenting between 2008 and 2018 to general practices contributing to the VetCompass Australia database. Patient records of interest were identified using search terms relating to allergic dermatitis, resulting in over 700,000 observations. Multivariable logistic regression models were developed to determine whether cases were prescribed fewer antimicrobial courses than controls, after adjusting for the presence of concurrent skin infections or infectious agents in ears. Our results indicate that fewer antimicrobial courses were prescribed in the cases compared to the controls. After adjusting for the concurrent skin infections, there was a significant reduction in the use of cefovecin [OR:0.62(0.39–0.98), P = 0.043], chlorhexidine [OR:0.57(0.42–0.77), P < 0.001], neomycin [OR:0.4(0.28–0.56), P < 0.001] and amoxycillin clavulanic acid (AMC) [OR: 0.55(0.39–0.78), P = 0.001] in cases compared to controls.

Conclusion
This study demonstrates a potential sparing effect of oclacitinib on the prescription of antimicrobials for the treatment of allergic skin diseases in dogs. This information may assist in the planning of treatment for canine allergic dermatitis, with consideration for antimicrobial stewardship.

KeywordsOclacitinib; Australia; Case-control study; Antimicrobial use; Canine allergic skin disease
Byline AffiliationsUniversity of Queensland
University of Southern Queensland
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