Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee

Article


Scott, A., Lian, O., Roberts, C. R., Cook, J. L., Handley, C. J., Bahr, R., Samiric, T., Ilic, M. Z., Parkinson, J., Hart, D. A., Duronio, V. and Khan, K. M.. 2008. "Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee." Scandinavian Journal of Medicine and Science in Sports. 18 (4), pp. 427-435. https://doi.org/10.1111/j.1600-0838.2007.00735.x
Article Title

Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee

ERA Journal ID9803
Article CategoryArticle
AuthorsScott, A. (Author), Lian, O. (Author), Roberts, C. R. (Author), Cook, J. L. (Author), Handley, C. J. (Author), Bahr, R. (Author), Samiric, T. (Author), Ilic, M. Z. (Author), Parkinson, J. (Author), Hart, D. A. (Author), Duronio, V. (Author) and Khan, K. M. (Author)
Journal TitleScandinavian Journal of Medicine and Science in Sports
Journal Citation18 (4), pp. 427-435
Number of Pages9
Year2008
PublisherJohn Wiley & Sons
Place of PublicationMalden, MA. United States
ISSN0905-7188
1600-0838
Digital Object Identifier (DOI)https://doi.org/10.1111/j.1600-0838.2007.00735.x
Abstract

Expansion of the extracellular matrix is a prominent but poorly characterized feature of tendinosis. The present study aimed to characterize the extent and distribution of the large aggregating proteoglycan versican in patients with patellar tendinosis. We obtained tendon from tendinopathy patients undergoing debridement of the patellar tendon and from controls undergoing intramedullary tibial nailing. Versican content was investigated by Western blotting and immunohistochemistry. Microvessel thickness and density were determined using computer-assisted image analysis. Markers for smooth muscle actin, endothelial cells (CD31) and proliferating cells (Ki67) were examined immunohistochemically. Western blot analysis and immunohistochemical staining revealed elevated versican content in the proximal patellar tendon of tendinosis patients (P=0.042). Versican content was enriched in regions of fibrocartilage metaplasia and fibroblast proliferation, as well as in the perivascular matrix of proliferating microvessels and within the media and intima of arterioles. Microvessel density was higher in tendinosis tissue compared with control tissue. Versican deposition is a prominent feature of patellar tendinosis. Because this molecule is not only a component of normal fibrocartilagenous matrices but also implicated in a variety of soft tissue pathologies, future studies should further detail both pathological and adaptive roles of versican in tendons.

Keywordsversican; patellar tendon; tendinosis; extracellular matrix
ANZSRC Field of Research 2020320405. Humoural immunology and immunochemistry
420701. Biomechanics
320899. Medical physiology not elsewhere classified
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Byline AffiliationsUniversity of British Columbia, Canada
Norwegian School of Sport Sciences, Norway
Deakin University
La Trobe University
University of Calgary, Canada
Institution of OriginUniversity of Southern Queensland
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