Serum levels of androgens in acne & their role in acne severity
Article
Article Title | Serum levels of androgens in acne & their role in acne severity |
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ERA Journal ID | 15419 |
Article Category | Article |
Authors | Iftikhar, Usma (Author) and Choudhry, Nakshab (Author) |
Journal Title | Pakistan Journal of Medical Sciences |
Journal Citation | 35 (1), pp. 146-150 |
Number of Pages | 5 |
Year | 2019 |
Place of Publication | Pakistan |
ISSN | 1681-715X |
1682-024X | |
Digital Object Identifier (DOI) | https://doi.org/10.12669/pjms.35.1.131 |
Web Address (URL) | http://pjms.org.pk/index.php/pjms/article/view/131 |
Abstract | Objectives: To correlate acne severity with elevated androgen levels and to compare androgen levels between cases and controls. Methods: This case-control study was carried out in the Department of Dermatology, Mayo Hospital, Lahore from March 2016 – March 2017. Two hundred and seventy patients and eighty age and gender-matched controls were recruited after ethical approval and informed consent and categorized into mild, moderate and severe acne. Severity was correlated with serum Testosterone, Dihydrotestoststerone and Dihydroepiandrosterone Sulphate levels. Quantitative variables were expressed as median and percentiles, comparisons done by Mann-Whitney and correlations by Spearman correlation. P-value of <0.05 was considered statistically significant. Results: There were 142 (41%) males and 208 (59%) females. Ninety-Seven patients had mild, 108 moderate and 65 had severe disease. Median hormonal levels were 3.5ng/ml, 184pg/ml and 0.82ug/dl for Testosterone, Dihydrotestosterone and Dihydroepiandrosterone Sulphate respectively which differed significantly between cases and controls. There was no correlation with severity but the levels differed significantly between the different grades in case of Testosterone and DHEAS. Conclusion: Androgens are not directly correlated with acne severity, but affect acne severity as seen in difference between their levels in different grades of acne. Anti-androgens may be initiated early in acne resistant to conventional therapy. |
Keywords | Acne vulgaris, Androgens, Hyperandrogenism, Acne Severity |
ANZSRC Field of Research 2020 | 320599. Medical biochemistry and metabolomics not elsewhere classified |
Byline Affiliations | King Edward Medical University, Pakistan |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q60w7/serum-levels-of-androgens-in-acne-their-role-in-acne-severity
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