Does insulin-like growth factor (IGF-1) gene polymorphism affect acne?
Paper
Paper/Presentation Title | Does insulin-like growth factor (IGF-1) gene polymorphism affect acne? |
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Presentation Type | Paper |
Authors | Iftikhar, U. |
Journal or Proceedings Title | Journal of Investigative Dermatology |
Journal Citation | 143 (5), pp. S152-S152 |
Number of Pages | 1 |
Year | 2023 |
Publisher | Elsevier |
Place of Publication | United Kingdom |
ISSN | 0022-202X |
1523-1747 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jid.2023.03.900 |
Web Address (URL) of Paper | https://www.jidonline.org/article/S0022-202X(23)01075-8/fulltext |
Web Address (URL) of Conference Proceedings | https://www.jidonline.org/issue/S0022-202X(23)X0004-9 |
Conference/Event | 1st International Societies for Investigative Dermatology (ISID) Meeting |
Event Details | 1st International Societies for Investigative Dermatology (ISID) Meeting Delivery In person Event Date 10 to end of 13 May 2023 Event Location Tokyo, Japan |
Abstract | Introduction: Acne vulgaris is the most typical disorder affecting adolescents. Heritability is 80% in first-degree relatives. Insulin-like growth factor (IGF-1) is structurally and functionally related to insulin. It consists of about 195 amino acids located on the cytogenetic band 12q23.2. Studies have shown an association between IGF-1 signaling which plays a role in acne by affecting IGF-1 levels and androgen metabolism. Variability in levels shows genetic regulation. There is a functional relationship between IGF (CA19) polymorphism and IGF-1 levels. Studies have shown varied incidences of polymorphism which needs further probing. Objectives: To determine IGF gene polymorphism frequency in acne in the Pakistani population and compare this between cases and controls. Methodology: Case-control study in Dermatology Department, Mayo Hospital, Lahore, Pakistan. Two hundred and seventy patients and 80 age and gender-matched controls were recruited by non-probability purposive sampling. Blood was drawn after an overnight fast for genomic DNA extraction and IGF-1 levels. PCR determined IGF-1 gene polymorphism. Forward primers were labeled with FAM (6-carboxyfluorescein) to analyze the PCR product. The frequency of polymorphisms and IGF-1 levels was compared between cases and controls. Quantitative variables were expressed as median and percentiles as data were non-normal. Comparisons were done by the Mann-Whitney U test and correlations by Spearman’s correlation. A p-value of ≤ 0.05 was considered statistically significant. Results: IGF-1 levels differed significantly between cases and controls. I87/x was the most frequent polymorphism in both patients and controls. In cases, the most frequent polymorphism was the (187/187) homozygous allele; in controls, it was the 187 heterozygous allele (187/x). The frequency of some polymorphisms was significantly higher in cases compared to controls. Gene polymorphism was significantly associated with serum IGF-1 levels. These findings will help in establishing a genetic and endocrine basis for acne and can be used in pharmacogenomics. |
ANZSRC Field of Research 2020 | 4299. Other health sciences |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | King Edward Medical University, Pakistan |
University of Southern Queensland |
https://research.usq.edu.au/item/z2964/does-insulin-like-growth-factor-igf-1-gene-polymorphism-affect-acne
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