Does insulin-like growth factor (IGF-1) gene polymorphism affect acne?


Iftikhar, U.. 2023. "Does insulin-like growth factor (IGF-1) gene polymorphism affect acne?" 1st International Societies for Investigative Dermatology (ISID) Meeting. Tokyo, Japan 10 - 13 May 2023 United Kingdom . Elsevier.
Paper/Presentation Title

Does insulin-like growth factor (IGF-1) gene polymorphism affect acne?

Presentation TypePaper
AuthorsIftikhar, U.
Journal or Proceedings TitleJournal of Investigative Dermatology
Journal Citation143 (5), pp. S152-S152
Number of Pages1
Place of PublicationUnited Kingdom
Digital Object Identifier (DOI)
Web Address (URL) of Paper
Web Address (URL) of Conference Proceedings
Conference/Event1st International Societies for Investigative Dermatology (ISID) Meeting
Event Details
1st International Societies for Investigative Dermatology (ISID) Meeting
In person
Event Date
10 to end of 13 May 2023
Event Location
Tokyo, Japan

Introduction: Acne vulgaris is the most typical disorder affecting adolescents. Heritability is 80% in first-degree relatives. Insulin-like growth factor (IGF-1) is structurally and functionally related to insulin. It consists of about 195 amino acids located on the cytogenetic band 12q23.2. Studies have shown an association between IGF-1 signaling which plays a role in acne by affecting IGF-1 levels and androgen metabolism. Variability in levels shows genetic regulation. There is a functional relationship between IGF (CA19) polymorphism and IGF-1 levels. Studies have shown varied incidences of polymorphism which needs further probing. Objectives: To determine IGF gene polymorphism frequency in acne in the Pakistani population and compare this between cases and controls. Methodology: Case-control study in Dermatology Department, Mayo Hospital, Lahore, Pakistan. Two hundred and seventy patients and 80 age and gender-matched controls were recruited by non-probability purposive sampling. Blood was drawn after an overnight fast for genomic DNA extraction and IGF-1 levels. PCR determined IGF-1 gene polymorphism. Forward primers were labeled with FAM (6-carboxyfluorescein) to analyze the PCR product. The frequency of polymorphisms and IGF-1 levels was compared between cases and controls. Quantitative variables were expressed as median and percentiles as data were non-normal. Comparisons were done by the Mann-Whitney U test and correlations by Spearman’s correlation. A p-value of ≤ 0.05 was considered statistically significant. Results: IGF-1 levels differed significantly between cases and controls. I87/x was the most frequent polymorphism in both patients and controls. In cases, the most frequent polymorphism was the (187/187) homozygous allele; in controls, it was the 187 heterozygous allele (187/x). The frequency of some polymorphisms was significantly higher in cases compared to controls. Gene polymorphism was significantly associated with serum IGF-1 levels. These findings will help in establishing a genetic and endocrine basis for acne and can be used in pharmacogenomics.

ANZSRC Field of Research 20204299. Other health sciences
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Byline AffiliationsKing Edward Medical University, Pakistan
University of Southern Queensland
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