Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives
Article
Ahmed, Waqas, Mushtaq, Asim, Ali, Shahzad, Khan, Nawaz, Liang, Yujie and Duan, Li. 2024. "Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives." ACS Biomaterials Science and Engineering. 10 (10), pp. 5960-5976. https://doi.org/10.1021/acsbiomaterials.4c00856
Article Title | Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives |
---|---|
ERA Journal ID | 210028 |
Article Category | Article |
Authors | Ahmed, Waqas, Mushtaq, Asim, Ali, Shahzad, Khan, Nawaz, Liang, Yujie and Duan, Li |
Journal Title | ACS Biomaterials Science and Engineering |
Journal Citation | 10 (10), pp. 5960-5976 |
Number of Pages | 17 |
Year | 2024 |
Publisher | American Chemical Society |
Place of Publication | United States |
ISSN | 2373-9878 |
Digital Object Identifier (DOI) | https://doi.org/10.1021/acsbiomaterials.4c00856 |
Web Address (URL) | https://pubs.acs.org/doi/10.1021/acsbiomaterials.4c00856 |
Abstract | Exosomes are nanoscale membrane bound vesicles secreted by almost all types of cells. Their unique attributes, such as minimal immunogenicity and compatibility with biological systems, make them novel carriers for drug delivery. These native exosomes harbor proteins, nucleic acids, small molecule compounds, and fluorogenic agents. Moreover, through a combination of chemical and bioengineering methodologies, exosomes are tailored to transport precise therapeutic payloads to designated cells or tissues. In this review, we summarize the strategies for exosome modification and drug loading modalities in engineered exosomes. In addition, we provide an overview of the advances in the use of engineered exosomes for targeted drug delivery. Lastly, we discuss the merits and limitations of chemically engineered versus bioengineered exosome-mediated target therapies. These insights offer additional options for refining engineered exosomes in pharmaceutical development and hold promise for expediting the successful translation of engineered exosomes from the bench to the bedside. |
Keywords | exosomes; biological engineering; chemical engineering; cargo loading; targeted delivery |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 400302. Biomaterials |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | First Affiliated Hospital of Shenzhen University, China |
Shenzhen University, China | |
Centre for Future Materials | |
Shenzhen Kangning Hospital, China |
Permalink -
https://research.usq.edu.au/item/z8631/engineering-approaches-for-exosome-cargo-loading-and-targeted-delivery-biological-versus-chemical-perspectives
32
total views0
total downloads4
views this month0
downloads this month