Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives

Article

Ahmed, Waqas, Mushtaq, Asim, Ali, Shahzad, Khan, Nawaz, Liang, Yujie and Duan, Li. 2024. "Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives." ACS Biomaterials Science and Engineering. 10 (10), pp. 5960-5976. https://doi.org/10.1021/acsbiomaterials.4c00856
Article Title

Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives

ERA Journal ID210028
Article CategoryArticle
AuthorsAhmed, Waqas, Mushtaq, Asim, Ali, Shahzad, Khan, Nawaz, Liang, Yujie and Duan, Li
Journal TitleACS Biomaterials Science and Engineering
Journal Citation10 (10), pp. 5960-5976
Number of Pages17
Year2024
PublisherAmerican Chemical Society
Place of PublicationUnited States
ISSN2373-9878
Digital Object Identifier (DOI)https://doi.org/10.1021/acsbiomaterials.4c00856
Web Address (URL)https://pubs.acs.org/doi/10.1021/acsbiomaterials.4c00856
AbstractExosomes are nanoscale membrane bound vesicles secreted by almost all types of cells. Their unique attributes, such as minimal immunogenicity and compatibility with biological systems, make them novel carriers for drug delivery. These native exosomes harbor proteins, nucleic acids, small molecule compounds, and fluorogenic agents. Moreover, through a combination of chemical and bioengineering methodologies, exosomes are tailored to transport precise therapeutic payloads to designated cells or tissues. In this review, we summarize the strategies for exosome modification and drug loading modalities in engineered exosomes. In addition, we provide an overview of the advances in the use of engineered exosomes for targeted drug delivery. Lastly, we discuss the merits and limitations of chemically engineered versus bioengineered exosome-mediated target therapies. These insights offer additional options for refining engineered exosomes in pharmaceutical development and hold promise for expediting the successful translation of engineered exosomes from the bench to the bedside.
Keywordsexosomes; biological engineering; chemical engineering; cargo loading; targeted delivery
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020400302. Biomaterials
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Byline AffiliationsFirst Affiliated Hospital of Shenzhen University, China
Shenzhen University, China
Centre for Future Materials
Shenzhen Kangning Hospital, China
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