Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives

Article

Ahmed, Waqas, Mushtaq, Asim, Ali, Shahzad, Khan, Nawaz, Liang, Yujie and Duan, Li. 2024. "Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives." ACS Biomaterials Science and Engineering. https://doi.org/10.1021/acsbiomaterials.4c00856

Article Title	Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives
ERA Journal ID	210028
Article Category	Article
Authors	Ahmed, Waqas, Mushtaq, Asim, Ali, Shahzad, Khan, Nawaz, Liang, Yujie and Duan, Li
Journal Title	ACS Biomaterials Science and Engineering
Number of Pages	17
Year	2024
Publisher	American Chemical Society
Place of Publication	United States
ISSN	2373-9878
Digital Object Identifier (DOI)	https://doi.org/10.1021/acsbiomaterials.4c00856
Web Address (URL)	https://pubs.acs.org/doi/10.1021/acsbiomaterials.4c00856
Abstract	Exosomes are nanoscale membrane bound vesicles secreted by almost all types of cells. Their unique attributes, such as minimal immunogenicity and compatibility with biological systems, make them novel carriers for drug delivery. These native exosomes harbor proteins, nucleic acids, small molecule compounds, and fluorogenic agents. Moreover, through a combination of chemical and bioengineering methodologies, exosomes are tailored to transport precise therapeutic payloads to designated cells or tissues. In this review, we summarize the strategies for exosome modification and drug loading modalities in engineered exosomes. In addition, we provide an overview of the advances in the use of engineered exosomes for targeted drug delivery. Lastly, we discuss the merits and limitations of chemically engineered versus bioengineered exosome-mediated target therapies. These insights offer additional options for refining engineered exosomes in pharmaceutical development and hold promise for expediting the successful translation of engineered exosomes from the bench to the bedside.
Keywords	exosomes; biological engineering; chemical engineering; cargo loading; targeted delivery
Contains Sensitive Content	Does not contain sensitive content
ANZSRC Field of Research 2020	400302. Biomaterials
Public Notes	Files associated with this item cannot be displayed due to copyright restrictions.
Byline Affiliations	First Affiliated Hospital of Shenzhen University, China
	Shenzhen University, China
	Centre for Future Materials
	Shenzhen Kangning Hospital, China

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