Origin and Development of Cancer Stem Cells

Edited book (chapter)

Chruscik, Anna. 2023. "Origin and Development of Cancer Stem Cells." Islam, Farhadul and Lam, Alfred K. (ed.) Cancer Stem Cells: Basic Concept and Therapeutic Implications. Singapore. Springer. pp. 17-43

Chapter Title	Origin and Development of Cancer Stem Cells
Book Chapter Category	Edited book (chapter)
ERA Publisher ID	3337
Book Title	Cancer Stem Cells: Basic Concept and Therapeutic Implications
Authors	Chruscik, Anna
Editors	Islam, Farhadul and Lam, Alfred K.
Page Range	17-43
Chapter Number	2
Number of Pages	27
Year	2023
Publisher	Springer
Place of Publication	Singapore
ISBN	9789819931859
	9789819931873
	9789819931842
Digital Object Identifier (DOI)	https://doi.org/10.1007/978-981-99-3185-9_2
Web Address (URL)	https://link.springer.com/chapter/10.1007/978-981-99-3185-9_2
Abstract	Cancer stem cells (CSCs) have been identified in a vast number of liquid and solid tumors and have been linked to poor patient prognosis and cancer recurrence. The ability to accurately identify and target this subset of cells presents opportunities for novel therapeutics. However, understanding how CSCs originate and develop is a crucial element to completing the puzzle. Stem cells are defined as being able to self-renew and differentiate and divide via two distinct models. Symmetric cell division increases the stem cell population, whereas asymmetric division maintains the number of stem cells within the population. While CSCs have been studied throughout decades, the current literature had revealed four main schools of thought regarding the origin and development of CSCs across a range of cancer types. This includes the symmetric and asymmetric cell division, genetic mutations and signaling pathways, the tumor microenvironment, and the embryonal rest theory. This current chapter introduces CSCs research history and provides an overview of the current theories regarding origin and development of CSCs.
Keywords	Cancer; Cancer stem cells; Stem cells; Development; Origin; History
Contains Sensitive Content	Does not contain sensitive content
ANZSRC Field of Research 2020	321101. Cancer cell biology
Public Notes	Files associated with this item cannot be displayed due to copyright restrictions.
Byline Affiliations	School of Health and Medical Sciences

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