An international survey on measures to prevent transfusion-transmitted infectious diseases—study results 1: Participation rates and the presence of laws, regulations, standards and best practices

Article

Conti, Galen, Epstein, Jay, Wendel, Silvano, Tagny, Claude Tayou, Lewin, Antoine, Lamba, Divjot Singh, Bust, Lesley, Kafere, Chancelar, Stanley, Jean, Roussakis, Maria, Kamel, Hany, Dodd, Roger Y., Stramer, Susan L. and ISBT Working Party for Global Blood Safety Subgroup on Harmonization of Regulations and Standards. 2025. "An international survey on measures to prevent transfusion-transmitted infectious diseases—study results 1: Participation rates and the presence of laws, regulations, standards and best practices." Vox Sanguinis: international journal of transfusion medicine. https://doi.org/10.1111/vox.70057
Article Title

An international survey on measures to prevent transfusion-transmitted infectious diseases—study results 1: Participation rates and the presence of laws, regulations, standards and best practices

ERA Journal ID16947
Article CategoryArticle
AuthorsConti, Galen, Epstein, Jay, Wendel, Silvano, Tagny, Claude Tayou, Lewin, Antoine, Lamba, Divjot Singh, Bust, Lesley, Kafere, Chancelar, Stanley, Jean, Roussakis, Maria, Kamel, Hany, Dodd, Roger Y., Stramer, Susan L. and ISBT Working Party for Global Blood Safety Subgroup on Harmonization of Regulations and Standards
Journal TitleVox Sanguinis: international journal of transfusion medicine
Number of Pages9
Year2025
PublisherJohn Wiley & Sons
ISSN0042-9007
1423-0410
Digital Object Identifier (DOI)https://doi.org/10.1111/vox.70057
Web Address (URL)https://onlinelibrary.wiley.com/doi/10.1111/vox.70057
Abstract

Background and Objectives
A global survey on blood safety measures to prevent transfusion-transmitted infectious diseases (TTIDs) was performed by examining variations in current usage. This analysis focuses on participation rates and the presence of relevant laws, regulations, standards and best practices for collection/processing of whole blood/components.

Materials and Methods
Distribution occurred between October 2023 and March 2024. States, provinces or cities within China and India were analysed as separate regions. Country/region (C/R) responses were categorized by World Bank income (WBI) levels: low- and lower middle-income (LLMI), upper middle-income (UMI) and high-income (HI). Consensus responses were used for multiple survey responses.

Results
Responses from 131 individuals representing 74 C/Rs (65 countries, Hong Kong, counted separately, and 8 regions in China/India) were analysed. Affirmative responses for laws, regulations and standards were similar across WBI levels. Regulatory jurisdiction for blood/components was present in 96% of C/Rs (HI 100%, UMI 100%, LLMI 87%) and 94% at a national level when present (HI 100%, UMI 94%, LLMI 85%). All HI, UMI and 74% LLMI C/Rs reported routinely separating whole blood into components. HI C/Rs were more likely to screen for bacterial contamination, whereas periodic platelet quality control was more common in LLMI and UMI C/Rs. Pathogen reduction and universal leukocyte reduction were more common in HI C/Rs.

Conclusion
Laws, regulations and standards for collection/processing of blood were consistent across WBI groups. Resource-intensive practices of blood component separation and use of advanced blood safety technologies were more variable, with less utilization in LLMI/UMI C/Rs.

Keywordsblood processing; blood regulation; global blood safety
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020320199. Cardiovascular medicine and haematology not elsewhere classified
320799. Medical microbiology not elsewhere classified
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Byline AffiliationsAmerican Red Cross, United States
International Society of Blood Transfusion, United States
Hospital Sirio-Libanês Blood Bank, Brazil
University Teaching Hospital, Cameroon
Medical Affairs and Innovation, Canada
University of Sherbrooke, Canada
Post Graduate Institute of Medical Education and Research, India
Africa Society for Blood Transfusion, South Africa
Paul-Ehrlich-Institut, Germany
Roche Diagnostic Solutions, United States
School of Health and Medical Sciences
International Society of Blood Transfusion, United States
Harmonization Subgroup of the ISBT Working Party on Global Blood Safety
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https://research.usq.edu.au/item/zy833/an-international-survey-on-measures-to-prevent-transfusion-transmitted-infectious-diseases-study-results-1-participation-rates-and-the-presence-of-laws-regulations-standards-and-best-practices

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An international survey on measures to prevent transfusion-transmitted infectious diseases—study results 2: Testing and donor vigilance
Conti, Galen, Epstein, Jay, Wendel, Silvano, Tagny, Claude Tayou, Lewin, Antoine, Lamba, Divjot Singh, Bust, Lesley, Kafere, Chancelar, Stanley, Jean, Roussakis, Maria, Kamel, Hany, Dodd, Roger Y., Stramer, Susan L. and Harmonization Subgroup of the ISBT Working Party on Global Blood Safety. 2025. "An international survey on measures to prevent transfusion-transmitted infectious diseases—study results 2: Testing and donor vigilance." Vox Sanguinis: international journal of transfusion medicine. https://doi.org/10.1111/vox.70056