Triamcinolone-induced cataract in eyes with diabetic macular oedema: 3-year prospective data from a randomized clinical trial

Article

Gillies, Mark C., Islam, Fakir M. A., Larsson, Jorgen, Pasadhika, Sirichai, Gaston, Chris, Zhu, Meidong and Wong, Tien Y.. 2010. "Triamcinolone-induced cataract in eyes with diabetic macular oedema: 3-year prospective data from a randomized clinical trial ." Clinical and Experimental Opthalmology. 38 (6), pp. 605-612. https://doi.org/10.1111/j.1442-9071.2010.02341.x
Article Title

Triamcinolone-induced cataract in eyes with diabetic macular oedema: 3-year prospective data from a randomized clinical trial

ERA Journal ID14283
Article CategoryArticle
AuthorsGillies, Mark C. (Author), Islam, Fakir M. A. (Author), Larsson, Jorgen (Author), Pasadhika, Sirichai (Author), Gaston, Chris (Author), Zhu, Meidong (Author) and Wong, Tien Y. (Author)
Journal TitleClinical and Experimental Opthalmology
Clinical and Experimental Ophthalmology
Journal Citation38 (6), pp. 605-612
Number of Pages8
Year2010
Place of PublicationMelbourne, Australia
ISSN1442-6404
1442-9071
Digital Object Identifier (DOI)https://doi.org/10.1111/j.1442-9071.2010.02341.x
Web Address (URL)http://onlinelibrary.wiley.com/doi/10.1111/j.1442-9071.2010.02341.x/pdf
Abstract

Purpose: To describe the 3-year risk of cataract after
intravitreal triamcinolone (IVTA) injections for diabetic
macular oedema and the outcomes of cataract surgery.
Methods: Prospective data from a randomized clinical trial were analysed. At baseline, 27 phakic eyes with diabetic macular oedema were randomized to receive IVTA and 25 to receive sham injection. After 2 years, initial sham-treated eyes were eligible to receive IVTA as the study became open label for the third year. The cumulative incidence of cataract surgery was the primary outcome of the study. Other
outcomes assessed included progression of cataract,
best-corrected logarithm of the minimal angle of resolution visual acuity before and after surgery and central macular thickness.
Results: Over the 3 years of the study, 15/27 (56%) phakic eyes in the IVTA treated group underwent cataract surgery as compared with 2/25 (8%) initial sham-treated eyes (P < 0.001). Mean visual acuity 6 months after cataract surgery was better than at entry into the trial. Two (15%) of the eyes in the IVTA-treated group undergoing cataract surgery had a loss of >15 letters. In the IVTA-treated group, 10/15
(67%) eyes that had three or more injections had progression of posterior subcapsular cataract by 2 grades as compared with only 2/12 (17%) eyes that had fewer than three injections (P = 0.009).
Conclusions: Over half of the eyes receiving IVTA injections for diabetic macular oedema required cataract surgery within 3 years. In eyes with three or more IVTA injections, two-thirds had progression of posterior subcapsular cataract. Visual outcomes after cataract surgery were generally good, although a small proportion of eyes lost greater than 15 letters over the course of the study.

Keywordscataract surgery; IVTA injection; macular oedema; visual acuity
ANZSRC Field of Research 2020321201. Ophthalmology
320507. Metabolic medicine
321204. Vision science
Public Notes

© 2010 Royal Australian and New Zealand College of Ophthalmologists.

Byline AffiliationsUniversity of Sydney
Department of Mathematics and Computing
University of Melbourne
Institution of OriginUniversity of Southern Queensland
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