Retinal fractal dimension is increased in persons with diabetes but not impaired glucose metabolism: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study

Article

Yau, J. W. Y., Kawasaki, R., Islam, F. M. A., Shaw, J., Zimmet, P., Wang, J. J. and Wong, T. Y.. 2010. "Retinal fractal dimension is increased in persons with diabetes but not impaired glucose metabolism: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study ." Diabetologia. 53 (9), pp. 2042-2045. https://doi.org/10.1007/s00125-010-1811-z
Article Title

Retinal fractal dimension is increased in persons with diabetes but not impaired glucose metabolism: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study

ERA Journal ID16025
Article CategoryArticle
AuthorsYau, J. W. Y. (Author), Kawasaki, R. (Author), Islam, F. M. A. (Author), Shaw, J. (Author), Zimmet, P. (Author), Wang, J. J. (Author) and Wong, T. Y. (Author)
Journal TitleDiabetologia
Journal Citation53 (9), pp. 2042-2045
Number of Pages4
Year2010
Place of PublicationHeidelberg, Germany
ISSN0012-186X
1432-0428
Digital Object Identifier (DOI)https://doi.org/10.1007/s00125-010-1811-z
Web Address (URL)http://www.springerlink.com/content/d71k533185324692/fulltext.pdf
Abstract

Aims/hypothesis: The fractal dimension (D f) of the retinal vasculature is a global measure of its branching pattern complexity. We examined the relationship of retinal D f with diabetes.
Methods: We conducted a cross-sectional study of 1,577 participants with diabetes and impaired glucose metabolism and normal controls from the population-based Australian Diabetes, Obesity and Lifestyle (AusDiab) study. Retinal D f was quantified from fundus photographs using a computer-based programme and diabetes status was determined by oral glucose tolerance test based on the WHO criteria. Results: After adjustment for age, sex and vascular risk factors, persons with higher retinal D f were more likely to have diabetes (OR 1.56; 95% CI 1.14-2.14, highest vs lowest fractal tertile). This relationship remained with further adjustment for retinal arteriolar calibre and presence of retinopathy (OR 1.64; 95% CI 1.19-2.27), and after excluding participants with retinopathy (OR 1.60; 95% CI 1.16-2.21). Retinal D f was not related to impaired glucose tolerance or impaired fasting glucose (OR 1.19; 95% CI 0.85-1.67).
Conclusions/interpretation: Individuals with diabetes, but not with impaired glucose metabolism, have greater retinal D f, reflecting greater complexity of the retinal vasculature. Our findings suggest the presence of early microvascular changes in the retinal vasculature of persons with diabetes, even in the absence of overt retinopathy.

Keywordsdiabetes; diabetic retinopathy; fundus photographs; impaired glucose metabolism; microvascular changes; retinal fractal dimension
ANZSRC Field of Research 2020320208. Endocrinology
320102. Haematology
321204. Vision science
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsUniversity of Melbourne
Department of Mathematics and Computing
Baker Heart and Diabetes Institute, Australia
University of Sydney
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q12yy/retinal-fractal-dimension-is-increased-in-persons-with-diabetes-but-not-impaired-glucose-metabolism-the-australian-diabetes-obesity-and-lifestyle-ausdiab-study

Log in to edit
  • 1683
    total views
  • 9
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Roles of the eye care workforce for task sharing in management of diabetic retinopathy in Cambodia
Shah, Mufarriq, Ormsby, Gial M., Noor, Ayesha, Chakrabarti, Rahul, Morchen, Manfred, Islam, Fakir M. Amirul, Harper, C. Alex and Keeffe, Jill E.. 2018. "Roles of the eye care workforce for task sharing in management of diabetic retinopathy in Cambodia." International Journal of Ophthalmology. 11 (1), pp. 101-107. https://doi.org/10.18240/ijo.2018.01.18
Attitudes and perceptions of eye care workers and health administrators regarding task sharing in screening and detection for management of diabetic retinopathy in Pakistan
Shah, Mufarriq, Noor, Ayesha, Ormsby, Gail M., Chakrabarti, Rahul, Harper, C. Alex, Islam, Fakir Amirul and Keeffe, Jill. 2018. "Attitudes and perceptions of eye care workers and health administrators regarding task sharing in screening and detection for management of diabetic retinopathy in Pakistan." Ophthalmic Epidemiology. 25 (2), pp. 169-175. https://doi.org/10.1080/09286586.2017.1381273
Task sharing: Development of evidence‐based co‐management strategy model for screening, detection, and management of diabetic retinopathy
Shah, Mufarriq, Noor, Ayesha, Ormsby, Gail M., Islam, Fakir Amirul, Harper, Colin Alex and Keeffe, Jill Elizabeth. 2018. "Task sharing: Development of evidence‐based co‐management strategy model for screening, detection, and management of diabetic retinopathy." International Journal of Health Planning and Management. 33 (4), pp. e1088-e1099. https://doi.org/10.1002/hpm.2590
An intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene indicates association with age-related macular degeneration
Richardson, Andrea J., Islam, F. M. Amirul, Aung, Khin Zaw, Guymer, Robyn H. and Baird, Paul N.. 2010. "An intergenic region between the tagSNP rs3793917 and rs11200638 in the HTRA1 gene indicates association with age-related macular degeneration." Investigative Ophthalmology and Visual Science. 51 (10), pp. 4932-4936. https://doi.org/10.1167/iovs.09-5114
Knowledge, Attitudes and Practice of Diabetes in Rural Bangladesh: The Bangladesh Population Based Diabetes and Eye Study (BPDES)
Islam, Fakir M. Amirul, Chakrabarti, Rahul, Dirani, Mohamed, Islam, M. Tauhidul, Ormsby, Gail, Wahab, Mohamed, Critchley, Christine and Finger, Robert P.. 2014. "Knowledge, Attitudes and Practice of Diabetes in Rural Bangladesh: The Bangladesh Population Based Diabetes and Eye Study (BPDES)." PLoS One. 9 (10), pp. 1-11. https://doi.org/10.1371/journal.pone.0110368
First contact diagnosis and management of contact lens-related complications
Fagan, Xavier J., Jhanji, Vishal, Constantinou, Marios, Islam, F. M. Amirul, Taylor, Hugh R. and Vajpayee, Rasik B.. 2012. "First contact diagnosis and management of contact lens-related complications." International Ophthalmology. 32 (4), pp. 321-327. https://doi.org/10.1007/s10792-012-9563-z
Long-term refractive outcomes and stability after excimer laser surgery for myopia
Dirani, Mohamed, Couper, Terry, Yau, Joanne, Ang, Enk K., Islam, F. M. Amirul, Snibson, Grant R., Vajpayee, Rasik B. and Baird, Paul N.. 2010. "Long-term refractive outcomes and stability after excimer laser surgery for myopia ." Journal of Cataract and Refractive Surgery. 36 (10), pp. 1709-1717. https://doi.org/10.1016/j.jcrs.2010.04.041
Triamcinolone-induced cataract in eyes with diabetic macular oedema: 3-year prospective data from a randomized clinical trial
Gillies, Mark C., Islam, Fakir M. A., Larsson, Jorgen, Pasadhika, Sirichai, Gaston, Chris, Zhu, Meidong and Wong, Tien Y.. 2010. "Triamcinolone-induced cataract in eyes with diabetic macular oedema: 3-year prospective data from a randomized clinical trial ." Clinical and Experimental Opthalmology. 38 (6), pp. 605-612. https://doi.org/10.1111/j.1442-9071.2010.02341.x
Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: a prospective study
Cheung, Ning, Mosley, Thomas, Islam, Amirul, Kawasaki, Ryo, Sharrett, A. Richey, Klein, Ronald, Coker, Laura H., Knopman, David S., Shibata, Dean K., Catellier, Diane and Wong, Tien Y.. 2010. "Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: a prospective study ." Brain. 133 (7), pp. 1987-1993. https://doi.org/10.1093/brain/awq127
Analysis of arsenic concentrations and correlation in water, soil and aurum by neutron activation analysis technique: a case study in Bagerhat, Bangladesh
Abdullah, S. M. A., Islam, M. T., Islam, S. Z., Hossain, Iqbal, Samsuzzoha, M., Hossain, M. D., Latif, S. A. and Islam, F. M. A.. 2010. "Analysis of arsenic concentrations and correlation in water, soil and aurum by neutron activation analysis technique: a case study in Bagerhat, Bangladesh." Bulletin of Environmental Contamination and Toxicology. 85 (3), pp. 301-306. https://doi.org/10.1007/s00128-010-0075-0