Retinal fractal dimension is increased in persons with diabetes but not impaired glucose metabolism: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study

Article

Yau, J. W. Y., Kawasaki, R., Islam, F. M. A., Shaw, J., Zimmet, P., Wang, J. J. and Wong, T. Y.. 2010. "Retinal fractal dimension is increased in persons with diabetes but not impaired glucose metabolism: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study ." Diabetologia. 53 (9), pp. 2042-2045. https://doi.org/10.1007/s00125-010-1811-z
Article Title

Retinal fractal dimension is increased in persons with diabetes but not impaired glucose metabolism: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study

ERA Journal ID16025
Article CategoryArticle
AuthorsYau, J. W. Y. (Author), Kawasaki, R. (Author), Islam, F. M. A. (Author), Shaw, J. (Author), Zimmet, P. (Author), Wang, J. J. (Author) and Wong, T. Y. (Author)
Journal TitleDiabetologia
Journal Citation53 (9), pp. 2042-2045
Number of Pages4
Year2010
Place of PublicationHeidelberg, Germany
ISSN0012-186X
1432-0428
Digital Object Identifier (DOI)https://doi.org/10.1007/s00125-010-1811-z
Web Address (URL)http://www.springerlink.com/content/d71k533185324692/fulltext.pdf
Abstract

Aims/hypothesis: The fractal dimension (D f) of the retinal vasculature is a global measure of its branching pattern complexity. We examined the relationship of retinal D f with diabetes.
Methods: We conducted a cross-sectional study of 1,577 participants with diabetes and impaired glucose metabolism and normal controls from the population-based Australian Diabetes, Obesity and Lifestyle (AusDiab) study. Retinal D f was quantified from fundus photographs using a computer-based programme and diabetes status was determined by oral glucose tolerance test based on the WHO criteria. Results: After adjustment for age, sex and vascular risk factors, persons with higher retinal D f were more likely to have diabetes (OR 1.56; 95% CI 1.14-2.14, highest vs lowest fractal tertile). This relationship remained with further adjustment for retinal arteriolar calibre and presence of retinopathy (OR 1.64; 95% CI 1.19-2.27), and after excluding participants with retinopathy (OR 1.60; 95% CI 1.16-2.21). Retinal D f was not related to impaired glucose tolerance or impaired fasting glucose (OR 1.19; 95% CI 0.85-1.67).
Conclusions/interpretation: Individuals with diabetes, but not with impaired glucose metabolism, have greater retinal D f, reflecting greater complexity of the retinal vasculature. Our findings suggest the presence of early microvascular changes in the retinal vasculature of persons with diabetes, even in the absence of overt retinopathy.

Keywordsdiabetes; diabetic retinopathy; fundus photographs; impaired glucose metabolism; microvascular changes; retinal fractal dimension
ANZSRC Field of Research 2020320208. Endocrinology
320102. Haematology
321204. Vision science
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Byline AffiliationsUniversity of Melbourne
Department of Mathematics and Computing
Baker Heart and Diabetes Institute, Australia
University of Sydney
Institution of OriginUniversity of Southern Queensland
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