A survey of macrocyclic lactone efficacy in Australian cyathostomin populations

Article

Beasley, A. M., Kotze, A. C., Allen, K. and Coleman, G. T.. 2017. "A survey of macrocyclic lactone efficacy in Australian cyathostomin populations." Veterinary Parasitology: Regional Studies and Reports. 8, pp. 127-132. https://doi.org/10.1016/j.vprsr.2017.03.009
Article Title

A survey of macrocyclic lactone efficacy in Australian cyathostomin populations

ERA Journal ID214435
Article CategoryArticle
AuthorsBeasley, A. M. (Author), Kotze, A. C. (Author), Allen, K. (Author) and Coleman, G. T. (Author)
Journal TitleVeterinary Parasitology: Regional Studies and Reports
Journal Citation8, pp. 127-132
Number of Pages6
Year2017
PublisherElsevier BV
Place of PublicationNetherlands
ISSN2405-9390
Digital Object Identifier (DOI)https://doi.org/10.1016/j.vprsr.2017.03.009
Abstract

The macrocyclic lactone (ML) drugs are central to the control of equine strongyles but recent international reports raise concerns about reduced efficacy of these drugs against cyathostomins. The objectives of the present study were firstly, to evaluate the efficacy of ML drugs against cyathostomins on a cross-section of Australian horse farms, and secondly, to determine the egg reappearance period (ERP) following treatment of horses with MLs. A total of 419 horses on 43 properties were treated orally with ivermectin, abamectin or moxidectin, at recommended dose rates and drug efficacy was determined using the faecal egg count reduction test. Efficacy of 100% at 14 days post-treatment was reported on all of the 43 farms. ERP following ivermectin treatment was 6 weeks on two properties and ERP following moxidectin treatment was 12 weeks on a third property. These ERPs are shorter than those reported at the time of commercial release of these drugs which likely reflects changing drug susceptibility of the cyathostomin populations tested. Ongoing surveillance of drug efficacy and ERPs should be part of an integrated management approach to equine worm control that prioritises the preservation of anthelmintic efficacy.

Keywordscyathostomins; egg reappearance period; ivermectin; macrocyclic lactones; resistance; strongyles; clinical and experimental pharmacology
ANZSRC Field of Research 2020300909. Veterinary parasitology
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Byline AffiliationsUniversity of Queensland
Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia
Institution of OriginUniversity of Southern Queensland
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