A survey of macrocyclic lactone efficacy in Australian cyathostomin populations

Article


Beasley, A. M., Kotze, A. C., Allen, K. and Coleman, G. T.. 2017. "A survey of macrocyclic lactone efficacy in Australian cyathostomin populations." Veterinary Parasitology: Regional Studies and Reports. 8, pp. 127-132. https://doi.org/10.1016/j.vprsr.2017.03.009
Article Title

A survey of macrocyclic lactone efficacy in Australian cyathostomin populations

ERA Journal ID214435
Article CategoryArticle
AuthorsBeasley, A. M. (Author), Kotze, A. C. (Author), Allen, K. (Author) and Coleman, G. T. (Author)
Journal TitleVeterinary Parasitology: Regional Studies and Reports
Journal Citation8, pp. 127-132
Number of Pages6
Year2017
PublisherElsevier BV
Place of PublicationNetherlands
ISSN2405-9390
Digital Object Identifier (DOI)https://doi.org/10.1016/j.vprsr.2017.03.009
Abstract

The macrocyclic lactone (ML) drugs are central to the control of equine strongyles but recent international reports raise concerns about reduced efficacy of these drugs against cyathostomins. The objectives of the present study were firstly, to evaluate the efficacy of ML drugs against cyathostomins on a cross-section of Australian horse farms, and secondly, to determine the egg reappearance period (ERP) following treatment of horses with MLs. A total of 419 horses on 43 properties were treated orally with ivermectin, abamectin or moxidectin, at recommended dose rates and drug efficacy was determined using the faecal egg count reduction test. Efficacy of 100% at 14 days post-treatment was reported on all of the 43 farms. ERP following ivermectin treatment was 6 weeks on two properties and ERP following moxidectin treatment was 12 weeks on a third property. These ERPs are shorter than those reported at the time of commercial release of these drugs which likely reflects changing drug susceptibility of the cyathostomin populations tested. Ongoing surveillance of drug efficacy and ERPs should be part of an integrated management approach to equine worm control that prioritises the preservation of anthelmintic efficacy.

Keywordscyathostomins; egg reappearance period; ivermectin; macrocyclic lactones; resistance; strongyles; clinical and experimental pharmacology
ANZSRC Field of Research 2020300909. Veterinary parasitology
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsUniversity of Queensland
Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q47w2/a-survey-of-macrocyclic-lactone-efficacy-in-australian-cyathostomin-populations

  • 895
    total views
  • 14
    total downloads
  • 2
    views this month
  • 0
    downloads this month

Export as

Related outputs

Prevalence of canine heartworm infection in Queensland, Australia: comparison of diagnostic methods and investigation of factors associated with reduction in antigen detection
Constantinoiu, Constantin, Croton, Catriona, Paterson, Mandy B. A., Knott, Lyn, Henning, Joerg, Mallyon, John and Coleman, Glen T.. 2023. "Prevalence of canine heartworm infection in Queensland, Australia: comparison of diagnostic methods and investigation of factors associated with reduction in antigen detection." Parasites and Vectors. 16 (1). https://doi.org/10.1186/s13071-022-05633-9
The 'Toolbox' of strategies for managing Haemonchus contortus in goats: What's in and what's out
Kearney, P. E., Murray, P. J., Hoy, J. M., Hohenhaus, M. and Kotze, A.. 2016. "The 'Toolbox' of strategies for managing Haemonchus contortus in goats: What's in and what's out." Veterinary Parasitology. 220, pp. 93-107. https://doi.org/10.1016/j.vetpar.2016.02.028
Client perspectives on desirable attributes and skills of veterinary technologists in Australia: considerations for curriculum design
Clarke, Patricia M., Al-Alawneh, John, Pitt, Rachael E., Schull, Daniel N. and Coleman, Glen T.. 2015. "Client perspectives on desirable attributes and skills of veterinary technologists in Australia: considerations for curriculum design." Journal of Veterinary Medical Education. 42 (3), pp. 217-231. https://doi.org/10.3138/jvme.0115-001R
Susceptibility of cat fleas (Siphonaptera: Pulicidae) to Fipronil and Imidacloprid using adult and larval bioassays
Rust, M. K., Vetter, R., Denholm, I., Blagburn, B., Williamson, M. S., Kopp, S., Coleman, G., Hostetler, J., Davis, W., Mencke, N., Rees, R., Foit, S. and Tetzner, K.. 2014. "Susceptibility of cat fleas (Siphonaptera: Pulicidae) to Fipronil and Imidacloprid using adult and larval bioassays." Journal of Medical Entomology. 51 (3), pp. 638-643. https://doi.org/10.1603/ME13240
Adaptation of a 96-well plate larval migration inhibition test for measuring the sensitivity of cyathostomins to macrocyclic lactone anthelmintics
Beasley, A. M., Coleman, G. T. and Kotze, A. C.. 2017. "Adaptation of a 96-well plate larval migration inhibition test for measuring the sensitivity of cyathostomins to macrocyclic lactone anthelmintics." Veterinary Parasitology. 245, pp. 55-61. https://doi.org/10.1016/j.vetpar.2017.08.010
Drug-efflux and target-site gene expression patterns in Haemonchus contortus larvae able to survive increasing concentrations of levamisole in vitro
Sarai, Ranbir S., Kopp, Steven R., Coleman, Glen T. and Kotze, Andrew C.. 2014. "Drug-efflux and target-site gene expression patterns in Haemonchus contortus larvae able to survive increasing concentrations of levamisole in vitro." International Journal for Parasitology: Drugs and Drug Resistance. 4 (2), pp. 77-84. https://doi.org/10.1016/j.ijpddr.2014.02.001
In vitro levamisole selection pressure on larval stages of Haemonchus contortus over nine generations gives rise to drug resistance and target site gene expression changes specific to the early larval stages only
Sarai, Ranbir S., Kopp, Steven R., Knox, Malcolm R., Coleman, Glen T. and Kotze, Andrew C.. 2015. "In vitro levamisole selection pressure on larval stages of Haemonchus contortus over nine generations gives rise to drug resistance and target site gene expression changes specific to the early larval stages only." Veterinary Parasitology. 211 (1-2), pp. 45-53. https://doi.org/10.1016/j.vetpar.2015.05.002
Suspected ivermectin resistance in a south-east Queensland parascaris equorum population
Beasley, A., Coleman, G. and Kotze, A. C.. 2015. "Suspected ivermectin resistance in a south-east Queensland parascaris equorum population." Australian Veterinary Journal. 93 (9), pp. 305-307. https://doi.org/10.1111/avj.12352
Susceptibility of adult cat fleas (Siphonaptera: Pulicidae) to insecticides and status of insecticide resistance mutations at the Rdl and knockdown resistance loci
Rust, Michael K., Vetter, Richard, Denholm, Ian, Blagburn, Byron, Williamson, Martin S., Kopp, Steven, Coleman, Glen, Hostetler, Joe, Davis, Wendell, Mencke, Norbert, Rees, Robert, Foit, Sabrina, Bohm, Claudia and Tetzner, Kathrin. 2015. "Susceptibility of adult cat fleas (Siphonaptera: Pulicidae) to insecticides and status of insecticide resistance mutations at the Rdl and knockdown resistance loci." Parasitology Research. 114, pp. 7-18. https://doi.org/10.1007/s00436-015-4512-1
Use of big data in the surveillance of veterinary diseases: early detection of tick paralysis in companion animals
Guernier, Vanina, Milinovich, Gabriel J., Santos, Marcos Antonio Bezerra, Haworth, Mark, Coleman, Glen and Soares Magalhaes, Ricardo J.. 2016. "Use of big data in the surveillance of veterinary diseases: early detection of tick paralysis in companion animals." Parasites and Vectors. 9 (1). https://doi.org/10.1186/s13071-016-1590-6
Preventive health care of Pony Club horses in rural New South Wales, Australia
Buckley, P., Buckley, D., Coleman, G. T. and Morton, J. M.. 2016. "Preventive health care of Pony Club horses in rural New South Wales, Australia." Australian Veterinary Journal. 94 (8), pp. 265-270. https://doi.org/10.1111/avj.12464