Susceptibility of adult cat fleas (Siphonaptera: Pulicidae) to insecticides and status of insecticide resistance mutations at the Rdl and knockdown resistance loci
Article
Article Title | Susceptibility of adult cat fleas (Siphonaptera: Pulicidae) to insecticides and status of insecticide resistance mutations at the Rdl and knockdown resistance loci |
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ERA Journal ID | 15193 |
Article Category | Article |
Authors | Rust, Michael K. (Author), Vetter, Richard (Author), Denholm, Ian (Author), Blagburn, Byron (Author), Williamson, Martin S. (Author), Kopp, Steven (Author), Coleman, Glen (Author), Hostetler, Joe (Author), Davis, Wendell (Author), Mencke, Norbert (Author), Rees, Robert (Author), Foit, Sabrina (Author), Bohm, Claudia (Author) and Tetzner, Kathrin (Author) |
Journal Title | Parasitology Research |
Journal Citation | 114, pp. 7-18 |
Number of Pages | 11 |
Year | 2015 |
Place of Publication | Germany |
ISSN | 0932-0113 |
1432-1955 | |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s00436-015-4512-1 |
Abstract | The susceptibility of 12 field-collected isolates and 4 laboratory strains of cat fleas, Ctenocephalides felis was determined by topical application of some of the insecticides used as on-animal therapies to control them. In the tested field-collected flea isolates the LD50 values for fipronil and imidacloprid ranged from 0.09 to 0.35 ng/flea and 0.02 to 0.19 ng/flea, respectively, and were consistent with baseline figures published previously. The extent of variation in response to four pyrethroid insecticides differed between compounds with the LD50 values for deltamethrin ranging from 2.3 to 28.2 ng/flea, etofenprox ranging from 26.7 to 86.7 ng/flea, permethrin ranging from 17.5 to 85.6 ng/flea, and d-phenothrin ranging from 14.5 to 130 ng/flea. A comparison with earlier data for permethrin and deltamethrin implied a level of pyrethroid resistance in all isolates and strains. LD50 values for tetrachlorvinphos ranged from 20.0 to 420.0 ng/flea. The rdl mutation (conferring target-site resistance to cyclodiene insecticides) was present in most field-collected and laboratory strains, but had no discernible effect on responses to fipronil, which acts on the same receptor protein as cyclodienes. The kdr and skdr mutations conferring target-site resistance to pyrethroids but segregated in opposition to one another, precluding the formation of genotypes homozygous for both mutations. |
Keywords | animals; ctenocephalides; gene expression regulation; genotype; insecticide resistance; insecticides; mutation; siphonaptera; microbiology; bacteriology; mycology |
ANZSRC Field of Research 2020 | 310902. Animal cell and molecular biology |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of California, United States |
University of Hertfordshire, United Kingdom | |
Auburn University, United States | |
Rothamsted Research, United Kingdom | |
University of Queensland | |
Bayer Animal Health, United States | |
Bayer Animal Health, Germany | |
Bayer Health Care, Australia | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q47w6/susceptibility-of-adult-cat-fleas-siphonaptera-pulicidae-to-insecticides-and-status-of-insecticide-resistance-mutations-at-the-rdl-and-knockdown-resistance-loci
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