Metabolic measures 12 months after a randomised controlled trial of treatment of clozapine associated obesity and diabetes with exenatide (CODEX)

Article


Siskind, Dan, Russell, A., Gamble, C., Baker, A., Cosgrove, P., Burton, L. and Kisely, S.. 2020. "Metabolic measures 12 months after a randomised controlled trial of treatment of clozapine associated obesity and diabetes with exenatide (CODEX)." Journal of Psychiatric Research. 124, pp. 9-12. https://doi.org/10.1016/j.jpsychires.2020.02.015
Article Title

Metabolic measures 12 months after a randomised controlled trial of treatment of clozapine associated obesity and diabetes with exenatide (CODEX)

ERA Journal ID13098
Article CategoryArticle
AuthorsSiskind, Dan (Author), Russell, A. (Author), Gamble, C. (Author), Baker, A. (Author), Cosgrove, P. (Author), Burton, L. (Author) and Kisely, S. (Author)
Journal TitleJournal of Psychiatric Research
Journal Citation124, pp. 9-12
Number of Pages4
Year2020
PublisherElsevier
Place of PublicationUnited Kingdom
ISSN0022-3956
1879-1379
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jpsychires.2020.02.015
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0022395619311355
Abstract

Clozapine is associated with obesity and type 2 diabetes. Glucagon-like-peptide-1 (GLP-1) receptor agonists such as exenatide can counter clozapine-associated GLP-1 dysregulation. Our 24-week randomized, controlled, open-label, pilot trial of once-weekly extended-release subcutaneous exenatide or usual care (CODEX) (n = 28), found exenatide was associated with significantly greater weight loss. We examined whether this effect was maintained at 12-months post-intervention. We followed up CODEX trial participants at 12-months post trial endpoint, collecting information on weight, BMI, waist circumference, blood pressure, fasting glucose, HbA1c, and use of metformin. The primary outcome of interest was change in weight from trial baseline to 12-months post endpoint and trial endpoint to 12-months post endpoint compared between former exenatide and usual care participants. Only HbA1c differed between baseline and 12-months post endpoint between the exenatide and control groups. From endpoint to 12-month follow up there were significantly greater increases among the former exenatide versus former usual care participants for weight, BMI, HbA1c and proportion with >5% weight gain. Stratifying results by whether participants used metformin post trial did not alter proportion with >5% weight gain. Although there were no significant differences in weight and BMI between baseline and 12-month post endpoint, there were significant increases in weight and BMI in the 12 months post endpoint for the former exenatide group. This was irrespective of metformin use and is in keeping with studies of other GLP-1RA agents. Further studies on GLP-1RAs use beyond 24 weeks for people with clozapine associated weight gain are needed.

KeywordsDiabetes; GLP-1RA; Metabolic syndrome; Obesity; Schizophrenia
ANZSRC Field of Research 2020420313. Mental health services
420309. Health management
420314. Multimorbidity
Byline AffiliationsDepartment of Health, Queensland
University of Queensland
Queensland Centre for Mental Health Research, Australia
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q6xx2/metabolic-measures-12-months-after-a-randomised-controlled-trial-of-treatment-of-clozapine-associated-obesity-and-diabetes-with-exenatide-codex

  • 86
    total views
  • 4
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Individual Resilience and Disaster-Specific Adaptation and Resilience Following a Bushfire Event in Regional Queensland
Rockloff, Susan F., Anderson, Carina C., Burton, Lucinda P., Terry, Victoria, Jensen, Sally K., Nolan, Anne and Terry, Peter C.. 2024. "Individual Resilience and Disaster-Specific Adaptation and Resilience Following a Bushfire Event in Regional Queensland." Sustainability. 16 (16), p. 7011. https://doi.org/10.3390/su16167011
Noosa bushfires: Collaborations and interconnections in a time of global change
Anderson, Carina, Rockloff, Susan, Burton, Lucinda and Terry, Victoria. 2024. "Noosa bushfires: Collaborations and interconnections in a time of global change." 2024 International Association for Society and Natural Resources (IASNR) Conference. Cairns, Australia 23 - 27 Jun 2024 Australia.
Building community resilience after the Noosa bushfires
Anderson, Carina, Terry, Victoria, Burton, Lucinda and Rockloff, Susan. 2023. "Building community resilience after the Noosa bushfires." Australian Disaster Resilience Conference 2023. Brisbane 23 - 24 Aug 2023 Australia.
Educating the educators: Implementing cultural safety in the nursing and midwifery curriculum
Best, Odette, Cox, Leonie, Ward, Aletha, Graham, Coralie, Bayliss, Luke, Black, Barbara, Burton, Lucinda, Carey, Melissa, Davis, Teresa, Derrington, Kate, Elliott, Jessie, Jayasinghe, Thenuja, Luyke, Trish, Maher, Dianne, McGregor, Rowena, Ng, Linda, O'Malley, Lee, Roderick, Geraldine, Sheridan, Georgina, ..., Walker, Jan. 2022. "Educating the educators: Implementing cultural safety in the nursing and midwifery curriculum." Nurse Education Today. 117, pp. 1-6. https://doi.org/10.1016/j.nedt.2022.105473
Protocol update and statistical analysis plan for CADENCE-BZ: a randomized clinical trial to assess the efficacy of sodium benzoate as an adjunctive treatment in early psychosis
Lim, Carmen, Baker, Andrea, Saha, Sukanta, Foley, Sharon, Gordon, Anne, Ward, David, Burgher, Bjorn, Dark, Frances, Beckmann, Martin, Stathis, Stephen, Bruxner, George, Ryan, Alex, Richardson, Drew, Hatherill, Sean, Berk, Michael, Dean, Olivia, McGrath, John, Working group, Cadence and Scott, James. 2019. "Protocol update and statistical analysis plan for CADENCE-BZ: a randomized clinical trial to assess the efficacy of sodium benzoate as an adjunctive treatment in early psychosis." Trials. 20, pp. 1-4. https://doi.org/10.1186/s13063-019-3232-8
Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis
Saha, Sukanta, Lim, Carmen C. W., Cannon, Danielle L., Burton, Lucinda, Bremner, Monique, Cosgrove, Peter, Yan, Huo and McGrath, John J.. 2020. "Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis." Depression and Anxiety. 38 (3), pp. 286-306. https://doi.org/10.1002/da.23113
Toilet Paper, Minced Meat and Diabetes Medicines: Australian Panic Buying Induced by COVID-19
Engstrom, Teyl, Baliunas, Dolly O., Sly, Benjamin P., Russell, Anthony W., Donovan, Peter J., Krausse, Heike K., Sullivan, Clair M. and Pole, Jason D. Pole. 2021. "Toilet Paper, Minced Meat and Diabetes Medicines: Australian Panic Buying Induced by COVID-19." International Journal of Environmental Research and Public Health. 18 (13). https://doi.org/10.3390/ijerph18136954
Cultural validation of the structured clinical interview for diagnostic and statistical manual of mental disorders in Indigenous Australians
Toombs, Maree, Nasir, Bushra, Kisely, Steve, Ranmuthugala, Geetha, Gill, Neeraj S., Beccaria, Gavin, Hayman, Noel, Kondalsamy-Chennakesavan, Srinivas N. and Nicholson, Geoffrey C.. 2019. "Cultural validation of the structured clinical interview for diagnostic and statistical manual of mental disorders in Indigenous Australians." Australasian Psychiatry. 27 (4), pp. 362-365. https://doi.org/10.1177/1039856219852289
A pilot study to assess the effects of Tai Chi on health indicators in type 1 diabetes patients
Liu, Xin, Russell, Anthony, Kabir, Enamul and Brown, Wendy. 2019. "A pilot study to assess the effects of Tai Chi on health indicators in type 1 diabetes patients." Health. 11, pp. 341-350. https://doi.org/10.4236/health.2019.113030
Common mental disorders among Indigenous people living in regional, remote and metropolitan Australia: a cross-sectional study
Nasir, Bushra F., Toombs, Maree T., Kondalsamy-Chennakesavan, Srinivas, Kisely, Steve, Gill, Neeraj S., Black, Emma, Hayman, Noel, Ranmuthugala, Geetha, Beccaria, Gavin, Ostini, Remo and Nicholson, Geoffrey C.. 2018. "Common mental disorders among Indigenous people living in regional, remote and metropolitan Australia: a cross-sectional study." BMJ Open. 8 (6), pp. 1-11. https://doi.org/10.1136/bmjopen-2017-020196
Mental Health and Indigenous Connection to Land and Community
Toombs, M., Kondalsamy-Chennakesavan, S., Kisely, S., Gill, N., Hayman, N., Ranmuthugala, G., Beccaria, G., Ostini, R., Nicholson, G. and Nasir, B.. 2018. "Mental Health and Indigenous Connection to Land and Community." Royal Australian & New Zealand College of Psychiatrists (RANZCP) 2018 Congress. New Zealand 12 201 - 17 May 2018 Australia. SAGE Publications Ltd.
The Cultural Appropriateness of the Structured Clinical Interview for DSM-IV TR, AXIS I for Indigenous Populations
Toombs, M, Nasir, B, Kisely, S, Kondalsamy-Chennakesavan, S, Gill, N, Black, E, Hayman, N, Ranmuthugala, G, Beccaria, G, Ostini, R and Nicholson, G. 2018. "The Cultural Appropriateness of the Structured Clinical Interview for DSM-IV TR, AXIS I for Indigenous Populations." Royal Australian & New Zealand College of Psychiatrists (RANZCP) 2018 Congress. New Zealand 12 201 - 17 May 2018 Australia. SAGE Publications Ltd. https://doi.org/10.1177/0004867418764980
Exploratory Study of Total and Free Prednisolone Plasma Exposure and Cushingoid Appearance, Quality of Life and Biochemical Toxicity in Adult Male Kidney Transplant Recipients
Bergmann, Troels K., Isbel, Nicole M., Ostini, Remo, Barraclough, Katherine A., Campbell, Scott B., McWhinney, Brett C., Inder, Warrick J., Russell, Anthony and Staatz, Christine E.. 2015. "Exploratory Study of Total and Free Prednisolone Plasma Exposure and Cushingoid Appearance, Quality of Life and Biochemical Toxicity in Adult Male Kidney Transplant Recipients." Clinical Drug Investigation. 35 (11), pp. 743-750. https://doi.org/10.1007/s40261-015-0334-2