Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis

Article


Rehm, Jürgen, Taylor, Benjamin, Mohapatra, Satya, Irving, Hyacinth, Baliunas, Dolly, Patra, Jayadeep and Roerecke, Michael. 2010. "Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis." Drug and Alcohol Review. 29 (4), pp. 437-45. https://doi.org/10.1111/j.1465-3362.2009.00153.x
Article Title

Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis

ERA Journal ID13493
Article CategoryArticle
AuthorsRehm, Jürgen, Taylor, Benjamin, Mohapatra, Satya, Irving, Hyacinth, Baliunas, Dolly, Patra, Jayadeep and Roerecke, Michael
Journal TitleDrug and Alcohol Review
Journal Citation29 (4), pp. 437-45
Number of Pages9
Year2010
PublisherJohn Wiley & Sons
Place of PublicationUnited Kingdom
ISSN0959-5236
1465-3362
Digital Object Identifier (DOI)https://doi.org/10.1111/j.1465-3362.2009.00153.x
Web Address (URL)https://www.ncbi.nlm.nih.gov/pubmed/20636661
AbstractINTRODUCTION AND AIMS: Alcohol is an established risk factor for liver cirrhosis. It remains unclear, however, whether this relationship follows a continuous dose-response pattern or has a threshold. Also, the influences of sex and end-point (i.e. mortality vs. morbidity) on the association are not known. To address these questions and to provide a quantitative assessment of the association between alcohol intake and risk of liver cirrhosis, we conducted a systematic review and meta-analysis of cohort and case-control studies. DESIGN AND METHODS: Studies were identified by a literature search of Ovid MEDLINE, EMBASE, Web of Science, CINAHL, PsychINFO, ETOH and Google Scholar from January 1980 to January 2008 and by searching the references of retrieved articles. Studies were included if quantifiable information on risk and related confidence intervals with respect to at least three different levels of average alcohol intake were reported. Both categorical and continuous meta-analytic techniques were used to model the dose-response relationship. RESULTS: Seventeen studies met the inclusion criteria. We found some indications for threshold effects. Alcohol consumption had a significantly larger impact on mortality of liver cirrhosis compared with morbidity. Also, the same amount of average consumption was related to a higher risk of liver cirrhosis in women than in men. DISCUSSION AND CONCLUSIONS: Overall, end-point was an important source of heterogeneity among study results. This result has important implications not only for studies in which the burden of disease attributable to alcohol consumption is estimated, but also for prevention.
Keywordsliver cirrhosis; meta-analysis; morbidity; mortality; alcohol
ANZSRC Field of Research 2020420201. Behavioural epidemiology
Public NotesFiles associated with this item cannot be displayed due to copyright restrictions.
Byline AffiliationsCentre for Addiction and Mental Health, Canada
University of Toronto, Canada
Dresden University of Technology, Germany
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