Alcohol as a risk factor for type 2 diabetes: A systematic review and meta-analysis

Article

Baliunas, Dolly O., Taylor, Benjamin J., Irving, Hyacinth, Roerecke, Michael, Patra, Jayadeep, Mohapatra, Satya and Rehm, Jürgen. 2009. "Alcohol as a risk factor for type 2 diabetes: A systematic review and meta-analysis." Diabetes Care. 32 (11), pp. 2123-2132. https://doi.org/10.2337/dc09-0227
Article Title

Alcohol as a risk factor for type 2 diabetes: A systematic review and meta-analysis

ERA Journal ID16018
Article CategoryArticle
AuthorsBaliunas, Dolly O., Taylor, Benjamin J., Irving, Hyacinth, Roerecke, Michael, Patra, Jayadeep, Mohapatra, Satya and Rehm, Jürgen
Journal TitleDiabetes Care
Journal Citation32 (11), pp. 2123-2132
Number of Pages10
Year2009
PublisherAmerican Diabetes Association
ISSN0149-5992
1935-5548
Digital Object Identifier (DOI)https://doi.org/10.2337/dc09-0227
Web Address (URL)https://diabetesjournals.org/care/article/32/11/2123/25991/Alcohol-as-a-Risk-Factor-for-Type-2-DiabetesA
Abstract

OBJECTIVE
To clarify the dose-response relationship between alcohol consumption and type 2 diabetes.

RESEARCH DESIGN AND METHODS
A systematic computer-assisted and hand search was conducted to identify relevant articles with longitudinal design and quantitative measurement of alcohol consumption. Adjustment was made for the sick-quitter effect. We used fractional polynomials in a meta-regression to determine the dose-response relationships by sex and end point using lifetime abstainers as the reference group.

RESULTS
The search revealed 20 cohort studies that met our inclusion criteria. A U-shaped relationship was found for both sexes. Compared with lifetime abstainers, the relative risk (RR) for type 2 diabetes among men was most protective when consuming 22 g/day alcohol (RR 0.87 [95% CI 0.76–1.00]) and became deleterious at just over 60 g/day alcohol (1.01 [0.71–1.44]). Among women, consumption of 24 g/day alcohol was most protective (0.60 [0.52–0.69]) and became deleterious at about 50 g/day alcohol (1.02 [0.83–1.26]).

CONCLUSIONS
Our analysis confirms previous research findings that moderate alcohol consumption is protective for type 2 diabetes in men and women.

KeywordsAlcohol ; Diabetes
ANZSRC Field of Research 2020420299. Epidemiology not elsewhere classified
Byline AffiliationsCentre for Addiction and Mental Health, Canada
University of Toronto, Canada
Dresden University of Technology, Germany
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