Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae
Article
Article Title | Mhp107 is a member of the multifunctional adhesin family |
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ERA Journal ID | 2230 |
Article Category | Article |
Authors | Seymour, Lisa M. (Author), Falconer, Linda (Author), Deutscher, Ania T. (Author), Minion, F. Chris (Author), Padula, Matthew P. (Author), Dixon, Nicholas E. (Author), Djordjevic, Steven P. (Author) and Walker, Mark J. (Author) |
Journal Title | Journal of Biological Chemistry |
Journal Citation | 286 (12), pp. 10097-10104 |
Number of Pages | 8 |
Year | 2011 |
Place of Publication | Rockville, MD. United States |
ISSN | 0021-9258 |
1083-351X | |
Digital Object Identifier (DOI) | https://doi.org/10.1074/jbc.M110.208140 |
Web Address (URL) | http://www.jbc.org/content/286/12/10097 |
Abstract | Mycoplasma hyopneumoniae is the causative pathogen of porcine enzootic pneumonia, an economically significant disease that disrupts the mucociliary escalator in the swine respiratory tract. Expression of Mhp107, a P97 paralog encoded by the gene mhp107, was confirmed using ESI-MS/MS. To investigate the function of Mhp107, three recombinant proteins, F1Mhp107, F2Mhp107, and F3Mhp107, spanning the N-terminal, central, and C-terminal regions of Mhp107 were constructed. Colonization of swine by M. hyopneumoniae requires adherenceof the bacterium to ciliated cells of the respiratory tract. |
Keywords | adhesin; fibronectin; heparin; plasminogen; protein Mhp107; recombinant protein; ciliated cells; amino terminal sequence; animal cell; animal experiment; bacterial colonization; bacterium adherence; carboxy terminal sequence; ciliated epithelium; fibronectins |
ANZSRC Field of Research 2020 | 300304. Animal protection (incl. pests and pathogens) |
310701. Bacteriology | |
300999. Veterinary sciences not elsewhere classified | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of Wollongong |
Elizabeth Macarthur Agricultural Institute, Australia | |
Iowa State University, United States | |
University of Technology Sydney | |
University of Queensland | |
Institution of Origin | University of Southern Queensland |
Funding source | Australian Research Council (ARC) Grant ID LP776771 |
https://research.usq.edu.au/item/q25z0/mhp107-is-a-member-of-the-multifunctional-adhesin-family-of-mycoplasma-hyopneumoniae
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