Anti-inflammatory activity and structure-activity relationships of brominated indoles from a marine mollusc
Article
Article Title | Anti-inflammatory activity and structure-activity relationships of brominated indoles from a marine mollusc |
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ERA Journal ID | 14994 |
Article Category | Article |
Authors | Ahmad, Tarek B. (Author), Rudd, David (Author), Smith, Joshua (Author), Kotiw, Michael (Author), Mouatt, Peter (Author), Seymour, Lisa M. (Author), Liu, Lei (Author) and Benkendorff, Kirsten (Author) |
Journal Title | Marine Drugs |
Journal Citation | 15 (5), pp. 1-19 |
Article Number | 133 |
Number of Pages | 19 |
Year | 2017 |
Place of Publication | Basel, Switzerland |
ISSN | 1660-3397 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/md15050133 |
Web Address (URL) | http://www.mdpi.com/1660-3397/15/5/133 |
Abstract | Marine molluscs are rich in biologically active natural products that provide new potential sources of anti-inflammatory agents. Here we used bioassay guided fractionation of extracts from the muricid Dicathais orbita to identify brominated indoles with anti-inflammatory activity, based on the inhibition of nitric oxide (NO) and tumour necrosis factor (TNF) in lipopolysaccharide (LPS) |
Keywords | marine natural products; inflammation; NO inhibition; Muricidae; isatin; Tyrian purple |
ANZSRC Field of Research 2020 | 420899. Traditional, complementary and integrative medicine not elsewhere classified |
Byline Affiliations | Southern Cross University |
Centre for Health Sciences Research | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q43zv/anti-inflammatory-activity-and-structure-activity-relationships-of-brominated-indoles-from-a-marine-mollusc
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