Anti-inflammatory activity and structure-activity relationships of brominated indoles from a marine mollusc

Article

Ahmad, Tarek B., Rudd, David, Smith, Joshua, Kotiw, Michael, Mouatt, Peter, Seymour, Lisa M., Liu, Lei and Benkendorff, Kirsten. 2017. "Anti-inflammatory activity and structure-activity relationships of brominated indoles from a marine mollusc." Marine Drugs. 15 (5), pp. 1-19. https://doi.org/10.3390/md15050133
Article Title

Anti-inflammatory activity and structure-activity relationships of brominated indoles from a marine mollusc

ERA Journal ID14994
Article CategoryArticle
AuthorsAhmad, Tarek B. (Author), Rudd, David (Author), Smith, Joshua (Author), Kotiw, Michael (Author), Mouatt, Peter (Author), Seymour, Lisa M. (Author), Liu, Lei (Author) and Benkendorff, Kirsten (Author)
Journal TitleMarine Drugs
Journal Citation15 (5), pp. 1-19
Article Number133
Number of Pages19
Year2017
Place of PublicationBasel, Switzerland
ISSN1660-3397
Digital Object Identifier (DOI)https://doi.org/10.3390/md15050133
Web Address (URL)http://www.mdpi.com/1660-3397/15/5/133
Abstract

Marine molluscs are rich in biologically active natural products that provide new potential sources of anti-inflammatory agents. Here we used bioassay guided fractionation of extracts from the muricid Dicathais orbita to identify brominated indoles with anti-inflammatory activity, based on the inhibition of nitric oxide (NO) and tumour necrosis factor (TNF) in lipopolysaccharide (LPS)
stimulated RAW264.7 macrophages and prostaglandin E2 (PGE2) in calcium ionophore-stimulated 3T3 ccl-92 fibroblasts. Muricid brominated indoles were then compared to a range of synthetic indoles to determine structure-activity relationships. Both hypobranchial gland and egg extracts inhibited the production of NO significantly with IC50 of 30.8 and 40 ug/mL, respectively. The hypobranchial gland extract also inhibited the production of TNFa and PGE2 with IC50 of 43.03 ug/mL and 34.24 ug/mL, respectively. The purified mono-brominated indole and isatin compounds showed
significant inhibitory activity against NO, TNFa, and PGE2, and were more active than dimer indoles and non-brominated isatin. The position of the bromine atom on the isatin benzene ring significantly affected the activity, with 5Br > 6Br > 7Br. The mode of action for the active hypobranchial gland extract, 6-bromoindole, and 6-bromoisatin was further tested by the assessment of the translocation of nuclear factor kappa B (NFkB) in LPS-stimulated RAW264.7 mouse macrophage. The extract
(40 ug/mL) significantly inhibited the translocation of NFkB in the LPS-stimulated RAW264.7 macrophages by 48.2%, whereas 40 ug/mL of 6-bromoindole and 6-bromoistain caused a 60.7% and 63.7% reduction in NFkB, respectively. These results identify simple brominated indoles as useful
anti-inflammatory drug leads and support the development of extracts from the Australian muricid D. orbita, as a new potential natural remedy for the treatment of inflammation.

Keywordsmarine natural products; inflammation; NO inhibition; Muricidae; isatin; Tyrian purple
ANZSRC Field of Research 2020420899. Traditional, complementary and integrative medicine not elsewhere classified
Byline AffiliationsSouthern Cross University
Centre for Health Sciences Research
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q43zv/anti-inflammatory-activity-and-structure-activity-relationships-of-brominated-indoles-from-a-marine-mollusc

Log in to edit

Download files

Published Version
marinedrugs-15-00133.pdf
License: CC BY 4.0
File access level: Anyone

  • 1172
    total views
  • 216
    total downloads
  • 3
    views this month
  • 2
    downloads this month

Export as

Related outputs

Supramolecular flame retardants enabled fire-extinguishing polycarbonate with enhanced thermal stability and reduced smoke release
Gao, Qingyao, Zhu, Menghe, Zhang, Jihang, Zhu, Jianhao, Liu, Xinliang, Xie, Chuanxin, Chen, Xilei, Liu, Lei and Song, Pingan. 2025. "Supramolecular flame retardants enabled fire-extinguishing polycarbonate with enhanced thermal stability and reduced smoke release." Chemical Engineering Journal. 504. https://doi.org/10.1016/j.cej.2024.158762
A ceramifiable organic-inorganic fire extinguishing hybrid coating capable of cyclic fire-warning
Liu, Xinliang, Zhu, Menghe, Zhu, Jianhao, Liu, Zhihui, Geng, Yiwei, Xie, Chuanxin, Chen, Xilei, Liu, Lei and Song, Pingan. 2025. "A ceramifiable organic-inorganic fire extinguishing hybrid coating capable of cyclic fire-warning." Polymer Degradation and Stability. 234. https://doi.org/10.1016/j.polymdegradstab.2025.111208
They're Only Human! Tension and Stress Predict Performance of Softball Umpires in National Championships
Houison, Ronald J., Lamont-Mills, Andrea, Kotiw, Michael and Terry, Peter C.. 2025. "They're Only Human! Tension and Stress Predict Performance of Softball Umpires in National Championships." Sports. 13 (2). https://doi.org/10.3390/sports13020035
Strike 3 … Out! Investigating Pre-Game Moods, Performance, and Mental Health of Softball Umpires
Houison, Ronald J., Lamont-Mills, Andrea, Kotiw, Michael and Terry, Peter C.. 2024. "Strike 3 … Out! Investigating Pre-Game Moods, Performance, and Mental Health of Softball Umpires." Sports. 12 (2). https://doi.org/10.3390/sports12020050
Engineering Sulfur-Containing Polymeric Fire-Retardant Coatings for Fire-Safe Rigid Polyurethane Foam
Fang, Yang, Ma, Zhewen, Wei, Dewang, Yu, Youming, Liu, Lei, Shi, Yongqian, Gao, Jiefeng, Tang, Long-Cheng, Huang, Guobo and Song, Pingan. 2024. "Engineering Sulfur-Containing Polymeric Fire-Retardant Coatings for Fire-Safe Rigid Polyurethane Foam." Macromolecular Rapid Communications. https://doi.org/10.1002/marc.202400068
Developing a selective culturing approach for Campylobacter hepaticus
Sakur, Sheaaz G. J., Williamson, Sarah L., Pavic, Anthony, Gao, Yuanshuo K., Harris, Taha, Kotiw, Michael, Muir, Wendy Isabelle and Groves, Peter John. 2024. "Developing a selective culturing approach for Campylobacter hepaticus." PLoS One. 19 (5). https://doi.org/10.1371/journal.pone.0302861
Descriptive epidemiology of Spotty Liver Disease in Australian cage-free brown egg layer chicken flocks with a scratch area
Groves, Peter J., Gao, Yuanshuo K., Kotiw, Michael, Eastwood, Sarah, Van, T. T. Hao Van, Moore, Robert J. and Muir, Wendy I.. 2024. "Descriptive epidemiology of Spotty Liver Disease in Australian cage-free brown egg layer chicken flocks with a scratch area." Poultry Science. 103 (8). https://doi.org/10.1016/j.psj.2024.103941
Chimeric hepatitis B surface antigen virus-like particles expressing the strep A epitope p*17 elicit a humoral immune response in mice
Dooley, Leanne, Ahmad, Tarek, Ozberk, Victoria, Pandey, Manisha, Good, Michael and Kotiw, Mkie. 2024. "Chimeric hepatitis B surface antigen virus-like particles expressing the strep A epitope p*17 elicit a humoral immune response in mice ." Heliyon. 10 (9). https://doi.org/10.1016/j.heliyon.2024.e30606
Feeling the Stress: Salivary Cortisol Responses of Softball Umpires during National Championships
Houison, Ronald J, Lamont-Mills, Andrea, Kotiw, Michael and Terry, Peter C.. 2024. "Feeling the Stress: Salivary Cortisol Responses of Softball Umpires during National Championships." Sports. 12 (5). https://doi.org/10.3390/sports12050128
On the intermolecular interactions and mechanical properties of polyvinyl alcohol/inositol supramolecular complexes
Wei, Dewang, Fang, Yang, Liu, Lei, Dai, Jinfeng, Yu, Youming, Hong, Min, Huo, Siqi, Xu, Zhiguang, Cao, Qianqian and Song, Pingan. 2024. "On the intermolecular interactions and mechanical properties of polyvinyl alcohol/inositol supramolecular complexes." Sustainable Materials and Technologies. 41. https://doi.org/10.1016/j.susmat.2024.e00990
Fire-retardant and high-strength polymeric materials enabled by supramolecular aggregates
Liu, Lei, Zhu, Menghe, Feng, Jiabing, Peng, Hong, Shi, Yongqian, Gao, Jiefeng, Tang, Long-Cheng and Song, Pingan. 2024. "Fire-retardant and high-strength polymeric materials enabled by supramolecular aggregates." Aggregate. 5 (2). https://doi.org/10.1002/agt2.494
Rethinking the pathway to sustainable fire retardants
Feng, Jiabing, Liu, Lei, Zhang, Yan, Wang, Qingsheng, Liang, Hong, Wang, Hao and Song, Pingan. 2023. "Rethinking the pathway to sustainable fire retardants." Exploration. 3 (4). https://doi.org/10.1002/EXP.20220088
Identification of epidemiological risk factors for spotty liver disease in cage-free layer flocks in houses with fully slatted flooring in Australia
Gao, Yuanshuo K., Singh, Mini, Muir, Wendy I., Kotiw, Michael and Groves, Peter J.. 2023. "Identification of epidemiological risk factors for spotty liver disease in cage-free layer flocks in houses with fully slatted flooring in Australia." Poultry Science. 102 (12). https://doi.org/10.1016/j.psj.2023.103139
Scratch area as an epidemiological risk factor for Spotty Liver Disease in cage-free layers in Australia
Gao, Yuanshuo K., Singh, Mini, Muir, Wendy I., Kotiw, Michael and Groves, Peter J.. 2023. "Scratch area as an epidemiological risk factor for Spotty Liver Disease in cage-free layers in Australia." Poultry Science. 102 (10). https://doi.org/10.1016/j.psj.2023.102922
Detection, characterization, and persistence of Campylobacter hepaticus, the cause of spotty liver disease in layer hens
Courtice, Jodi M., Ahmad, Tarek B., Wei, Chuanyu, Mahdi, Layla K., Palmieri, Chiara, Juma, Sarah, Groves, Peter J., Hancock, Kerry, Korolik, Victoria, Petrovsky, Nikolai and Kotiw, Michael. 2023. "Detection, characterization, and persistence of Campylobacter hepaticus, the cause of spotty liver disease in layer hens." Poultry Science. 102 (7). https://doi.org/10.1016/j.psj.2022.102462
An iron phenylphosphinate@graphene oxide nanohybrid enabled flame-retardant, mechanically reinforced, and thermally conductive epoxy nanocomposites
Chen, Qiang, Liu, Lei, Zhang, Anlin, Wang, Wenduo, Wang, Zhengzhou, Zhang, Jianzhong, Feng, Jiabing, Huo, Siqi, Zeng, Xuesen and Song, Pingan. 2023. "An iron phenylphosphinate@graphene oxide nanohybrid enabled flame-retardant, mechanically reinforced, and thermally conductive epoxy nanocomposites." Chemical Engineering Journal. 454. https://doi.org/10.1016/j.cej.2022.140424
Superhydrophobic self-extinguishing cotton fabrics for electromagnetic interference shielding and human motion detection
Liu, Lei, Ma, Zhewen, Zhu, Menghe, Liu, Lina, Dai, Jinfeng, Shi, Yongqian, Gao, Jiefeng, Dinh, Toan, Nguyen, Thanh, Tang, Long-Cheng and Song, Pingan. 2023. "Superhydrophobic self-extinguishing cotton fabrics for electromagnetic interference shielding and human motion detection ." Journal of Materials Science and Technology. 132, pp. 59-68. https://doi.org/10.1016/j.jmst.2022.05.036
Bioinspired Strong, Tough, and Biodegradable Poly(Vinyl Alcohol) and its Applications as Substrates for Humidity Sensors
Liu, Lei, Xu, Xiaodong, Zhu, Menghe, Cui, Xihua, Feng, Jiabing, Faraji Rad, Zahra, Wang, Hao and Song, Pingan. 2023. "Bioinspired Strong, Tough, and Biodegradable Poly(Vinyl Alcohol) and its Applications as Substrates for Humidity Sensors." Advanced Materials Technologies. https://doi.org/10.1002/admt.202201414
2D MXenes for Fire Retardancy and Fire-Warning Applications: Promises and Prospects
Liu, Lei, Feng, Jiabing, Xue, Yijiao, Chevali, Venkata, Zhang, Yubai, Shi, Yongqian, Tang, Longcheng and Song, Pingan. 2023. "2D MXenes for Fire Retardancy and Fire-Warning Applications: Promises and Prospects ." Advanced Functional Materials. 33 (9). https://doi.org/10.1002/adfm.202212124
Small multiamine molecule enabled fire-retardant polymeric materials with enhanced strength, toughness, and self-healing properties
Liu, Lei, Zhu, Menghe, Ma, Zhewen, Xu, Xiaodong, Dai, Jinfeng, Yu, Youming, Seraji, Seyed Mohsen, Wang, Hao and Song, Pingan. 2022. "Small multiamine molecule enabled fire-retardant polymeric materials with enhanced strength, toughness, and self-healing properties." Chemical Engineering Journal. 400, pp. 1-11. https://doi.org/10.1016/j.cej.2022.135645
A reactive copper-organophosphate-MXene heterostructure enabled antibacterial, self-extinguishing and mechanically robust polymer nanocomposites
Liu, Lei, Zhu, Menghe, Ma, Zhewen, Xu, Xiaodong, Seraji, Seyed Mohsen, Yu, Bin, Sun, Ziqi, Wang, Hao and Song, Pingan. 2022. "A reactive copper-organophosphate-MXene heterostructure enabled antibacterial, self-extinguishing and mechanically robust polymer nanocomposites." Chemical Engineering Journal. 430, pp. 1-12. https://doi.org/10.1016/j.cej.2021.132712
A highly fire-retardant rigid polyurethane foam capable of fire-warning
Ma, Zhewen, Zhang, Jianzhong, Liu, Lei, Zheng, Hua, Dai, Jinfeng, Tang, Long-Cheng and Song, Pingan. 2021. "A highly fire-retardant rigid polyurethane foam capable of fire-warning." Composites Communications. 29, pp. 1-6. https://doi.org/10.1016/j.coco.2021.101046
Recent advances in fire-retardant rigid polyurethane foam
Zhu, Menghe, Ma, Zhewen, Liu, Lei, Zhang, Jianzhong, Huo, Siqi and Song, Pingan. 2021. "Recent advances in fire-retardant rigid polyurethane foam." Journal of Materials Science and Technology. 112, pp. 315-328. https://doi.org/10.1016/j.jmst.2021.09.062
Scalable, Robust, Low-Cost, and Highly Thermally Conductive Anisotropic Nanocomposite Films for Safe and Efficient Thermal Management
Chen, Qiang, Ma, Zhewen, Wang, Zhengzhou, Liu, Lei, Zhu, Menghe, Lei, Weiwei and Song, Pingan. 2021. "Scalable, Robust, Low-Cost, and Highly Thermally Conductive Anisotropic Nanocomposite Films for Safe and Efficient Thermal Management." Advanced Functional Materials. 32 (8). https://doi.org/10.1002/adfm.202110782
Dynamic Nanoconfinement Enabled Highly Stretchable and Supratough Polymeric Materials with Desirable Healability and Biocompatibility
Liu, Lei, Zhu, Menghe, Xu, Xiaodong, Ma, Zhewen, Jiang, Zhen, Pich, Andrij, Wang, Hao, Song, Pingan and Li, X.. 2021. "Dynamic Nanoconfinement Enabled Highly Stretchable and Supratough Polymeric Materials with Desirable Healability and Biocompatibility." Advanced Materials. 33 (51), pp. 1-11. https://doi.org/10.1002/adma.202105829
Bioinspired, Strong, and Tough Nanostructured Poly(vinyl alcohol)/Inositol Composites: How Hydrogen-Bond Cross-Linking Works?
Xu, Xiaodong, Li, Lujuan, Seraji, Seyed Mohsen, Liu, Lei, Jiang, Zhen, Xu, Zhiguang, Li, Xin, Zhao, Sheng, Wang, Hao and Song, Pingan. 2020. "Bioinspired, Strong, and Tough Nanostructured Poly(vinyl alcohol)/Inositol Composites: How Hydrogen-Bond Cross-Linking Works?" Macromolecules. 54 (20), pp. 9510-9521. https://doi.org/10.1021/acs.macromol.1c01725
Bioinspired, Highly Adhesive, Nanostructured Polymeric Coatings for Superhydrophobic Fire-Extinguishing Thermal Insulation Foam
Ma, Zhewen, Liu, Xiaochen, Xu, Xiaodong, Liu, Lei, Yu, Bin, Maluk, Cristian, Huang, Guobo, Wang, Hao and Song, Pingan. 2021. "Bioinspired, Highly Adhesive, Nanostructured Polymeric Coatings for Superhydrophobic Fire-Extinguishing Thermal Insulation Foam." ACS Nano. 15 (7), pp. 11667-11680. https://doi.org/10.1021/acsnano.1c02254
Functionalizing MXene towards highly stretchable, ultratough, fatigue- and fire-resistant polymer nanocomposites
Liu, Lei, Zhu, Menghe, Shi, Yongqian, Xu, Xiaodong, Ma, Zhewen, Yu, Bin, Fu, Shenyuan, Huang, Guobo, Wang, Hao and Song, Pingan. 2021. "Functionalizing MXene towards highly stretchable, ultratough, fatigue- and fire-resistant polymer nanocomposites." Chemical Engineering Journal. 424, pp. 1-13. https://doi.org/10.1016/j.cej.2021.130338
Molecularly Engineered Lignin-Derived Additives Enable Fire-Retardant, UV-Shielding, and Mechanically Strong Polylactide Biocomposites
Yang, Haitang, Shi, Bingbing, Xue, Yijiao, Ma, Zhewen, Liu, Lina, Liu, Lei, Yu, Youming, Zhang, Zhanying, Annamalai, Pratheep K. and Song, Pingan. 2021. "Molecularly Engineered Lignin-Derived Additives Enable Fire-Retardant, UV-Shielding, and Mechanically Strong Polylactide Biocomposites." Biomacromolecules. 22 (4), pp. 1432-1444. https://doi.org/10.1021/acs.biomac.0c01656
Water governs the mechanical properties of poly(vinyl alcohol)
Li, Lujuan, Xu, Xiaodong, Liu, Lei, Song, Pingan, Cao, Qianqian, Xu, Zhiguang, Fang, Zhengping and Wang, Hao. 2021. "Water governs the mechanical properties of poly(vinyl alcohol)." Polymer. 213, pp. 1-12. https://doi.org/10.1016/j.polymer.2020.123330
Catalysis based on ferroelectrics: controllable chemical reaction with boosted efficiency
Wan, Tsz Lok, Ge, Lei, Pan, Yangli, Yuan, Qinghong, Liu, Lei, Sarina, Sarina and Kou, Liangzhi. 2021. "Catalysis based on ferroelectrics: controllable chemical reaction with boosted efficiency." Nanoscale. 13 (15), pp. 7096-7107. https://doi.org/10.1039/d1nr00847a
Phosphorus-containing flame retardant epoxy thermosets: Recent advances and future perspectives
Huo, Siqi, Song, Pingan, Yu, Bin, Ran, Shiya, Chevali, Venkata, Liu, Lei, Fang, Zhengping and Wang, Hao. 2021. "Phosphorus-containing flame retardant epoxy thermosets: Recent advances and future perspectives." Progress in Polymer Science. 114, pp. 1-36. https://doi.org/10.1016/j.progpolymsci.2021.101366
Spotty Liver Disease: A South East Queensland Perspective and Research Progress
Kotiw, Michael and Courtice, Jodi. 2018. "Spotty Liver Disease: A South East Queensland Perspective and Research Progress." Poultry Information Exchange and Australasian Milling Conference (PIX/AMC 2018). Gold Coast, Australia 03 - 05 Jun 2018
Field Trials of a Spotty Liver Disease Vaccine: Vaccine Trial 1: Small scale Trial
Courtice, Jodi M., Ahmad, Tarek B., Wei, Chuanyu, Groves, Peter J., Gao, Karen, Phoon, Olivia C., Palmieri, Chiara, Petrovsky, Nikolai and Kotiw, Michael. 2020. "Field Trials of a Spotty Liver Disease Vaccine: Vaccine Trial 1: Small scale Trial." 2020 Australasian Veterinary Poultry Association (AVPA) Annual Scientific Meeting. Online 20 - 21 May 2020
Progress in the pathobiology and genetic epidemiology of Campylobacter hepaticus, the aetiological agent of Spotty Liver Disease
Kotiw, M., Courtice, J., Mahdi, L., Wei, C., Ahmad, T., Hancock, K. and Groves, P.. 2019. "Progress in the pathobiology and genetic epidemiology of Campylobacter hepaticus, the aetiological agent of Spotty Liver Disease." 2019 Australasian Veterinary Poultry Association (AVPA) Annual Scientific Meeting. Sydney, Australia 20 - 21 Feb 2019
Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production
Courtice, Jodi Maree, Mahdi, Layla Khalid, Groves, Peter John and Kotiw, Michael. 2018. "Spotty Liver Disease: A review of an ongoing challenge in commercial free-range egg production." Veterinary Microbiology. 227, pp. 112-118. https://doi.org/10.1016/j.vetmic.2018.08.004
Spotty Liver Disease and Risk Factors
Gao, Yuanshou Karen, Singh, Mini, Muir, Wendy, Williamson, Sarah, Sharpe, Sue, Kotiw, Mike and Groves, Peter. 2021. "Spotty Liver Disease and Risk Factors." 2021 Australasian Veterinary Poultry Association (AVPA) Annual Scientific Meeting. Online 11 - 12 Feb 2021
Polyphosphoramide-intercalated MXene for simultaneously enhancing the thermal stability, flame retardancy and mechanical properties of polylactide
Xue, Yijiao, Feng, Jiabing, Huo, Siqi, Song, Pingan, Yu, Bin, Liu, Lei and Wang, Hao. 2020. "Polyphosphoramide-intercalated MXene for simultaneously enhancing the thermal stability, flame retardancy and mechanical properties of polylactide." Chemical Engineering Journal. 397, pp. 1-11. https://doi.org/10.1016/j.cej.2020.125336
Grafting Lignin with Bioderived Polyacrylates for Low-Cost, Ductile, and Fully Biobased Poly(lactic acid) Composite
Sun, Yiqi, Ma, Zhewen, Xu, Xiaodong, Liu, Xiaohuan, Liu, Lina, Huang, Guobo, Liu, Lei, Wang, Hao and Song, Pingan. 2020. "Grafting Lignin with Bioderived Polyacrylates for Low-Cost, Ductile, and Fully Biobased Poly(lactic acid) Composite." ACS Sustainable Chemistry and Engineering. 8 (5), pp. 2267-2276. https://doi.org/10.1021/acssuschemeng.9b06593
Rheumatic heart disease: A review of the current status of global research activity
Dooley, Leanne M., Ahmad, Tarek B., Pandey, Manisha, Good, Micheal F. and Kotiw, Michael. 2021. "Rheumatic heart disease: A review of the current status of global research activity." Autoimmunity Reviews. 20 (2), pp. 1-23. https://doi.org/10.1016/j.autrev.2020.102740
Viral vs bacterial vectors for vaccine delivery
Kotiw, Michael. 2011. "Viral vs bacterial vectors for vaccine delivery." Mei, Xiaodan (ed.) 3rd Annual World Vaccine Congress: The Future of Global Vaccines (WCV 2011). Beijing, China 23 - 25 Mar 2011 Dalian, China.
Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats
John, Oliver D., Mouatt, Peter, Panchal, Sunil K. and Brown, Lindsay. 2021. "Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats." Nutrients. 13 (2), pp. 1-19. https://doi.org/10.3390/nu13020319
Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats
Bhandarkar, Nikhil S., Mouatt, Peter, Majzoub, Marwan E., Thomas, Torsten, Brown, Lindsay and Panchal, Sunil K.. 2021. "Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats ." Pathogens. 10 (11). https://doi.org/10.3390/pathogens10111369
Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats
du Preez, Ryan, Wanyonyi, Stephen, Mouatt, Peter, Panchal, Sunil K. and Brown, Lindsay. 2020. "Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats." Nutrients. 12 (4), pp. 1-16. https://doi.org/10.3390/nu12040931
Carrageenans from the Red Seaweed Sarconema filiforme Attenuate Symptoms of Diet-Induced Metabolic Syndrome in Rats
du Preez, Ryan, Paul, Nicholas, Mouatt, Peter, Majzoub, Marwan E., Thomas, Torsten, Panchal, Sunil K. and Brown, Lindsay. 2020. "Carrageenans from the Red Seaweed Sarconema filiforme Attenuate Symptoms of Diet-Induced Metabolic Syndrome in Rats." Marine Drugs. 18 (2), pp. 1-26. https://doi.org/10.3390/md18020097
Modulation of gut microbiota by spent coffee grounds attenuates diet-induced metabolic syndrome in rats
Bhandarkar, Nikhil S., Mouatt, Peter, Goncalves, Priscila, Thomas, Torsten, Brown, Lindsay and Panchal, Sunil K.. 2020. "Modulation of gut microbiota by spent coffee grounds attenuates diet-induced metabolic syndrome in rats." The FASEB Journal. 34 (3), pp. 4783-4797. https://doi.org/10.1096/fj.201902416RR
Physiological and metabolic effects of yellow mangosteen (Garcinia dulcis) rind in rats with food-induced metabolic syndrome
John, Oliver D., Mouatt, Peter, Majzoub, Marwan E., Thomas, Torsten, Panchal, Sunil K. and Brown, Lindsay. 2019. "Physiological and metabolic effects of yellow mangosteen (Garcinia dulcis) rind in rats with food-induced metabolic syndrome." International Journal of Molecular Sciences. 21 (1), pp. 1-29. https://doi.org/10.3390/ijms21010272
Correlation between fatty acid profile and anti-inflammatory activity in common Australian sea-food by-products
Ahmad, Tarek B., Rudd, David, Kotiw, Michael, Liu, Lei and Benkendorff, Kirsten. 2019. "Correlation between fatty acid profile and anti-inflammatory activity in common Australian sea-food by-products." Marine Drugs. 17 (3), pp. 1-20. https://doi.org/10.3390/md17030155
Green coffee ameliorates components of diet-induced metabolic syndrome in rats
Bhandarkar, Nikhil S., Mouatt, Peter, Brown, Lindsay and Panchal, Sunil K.. 2019. "Green coffee ameliorates components of diet-induced metabolic syndrome in rats." Journal of Functional Foods. 57, pp. 141-149. https://doi.org/10.1016/j.jff.2019.04.003
The edible native Australian fruit, Davidson’s plum (Davidsonia pruriens), reduces symptoms in rats with diet-induced metabolic syndrome
John, Oliver D., Mouatt, Peter, Prasadam, Indira, Xiao, Yin, Panchal, Sunil K. and Brown, Lindsay. 2019. "The edible native Australian fruit, Davidson’s plum (Davidsonia pruriens), reduces symptoms in rats with diet-induced metabolic syndrome." Journal of Functional Foods. 56, pp. 204-215. https://doi.org/10.1016/j.jff.2019.03.018
Achacha (Garcinia humilis) Rind Improves Cardiovascular Function in Rats with Diet-Induced Metabolic Syndrome
John, Oliver D., Wanyonyi, Stephen, Mouatt, Peter, Panchal, Sunil K. and Brown, Lindsay. 2018. "Achacha (Garcinia humilis) Rind Improves Cardiovascular Function in Rats with Diet-Induced Metabolic Syndrome." Nutrients. 10 (10), pp. 1-15. https://doi.org/10.3390/nu10101425
Review of anti-inflammatory, immune-modulatory and wound healing properties of molluscs
Ahmad, Tarek B., Liu, Lei, Kotiw, Michael and Benkendorff, Kirsten. 2018. "Review of anti-inflammatory, immune-modulatory and wound healing properties of molluscs." Journal of Ethnopharmacology. 210, pp. 156-178. https://doi.org/10.1016/j.jep.2017.08.008
Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury
Ahmad, Tarek B., Rudd, David, Benkendorff, Kirsten, Mahdi, Layla K., Pratt, Kayla-Ann, Dooley, Leanne, Wei, Chuanyu and Kotiw, Michael. 2017. "Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury." PLoS One. 12 (10). https://doi.org/10.1371/journal.pone.0186904
Anthocyanins in chokeberry and purple maize attenuate diet-induced metabolic syndrome in rats
Bhaswant, Maharshi, Shafie, Siti Raihanah, Mathai, Michael L., Mouatt, Peter and Brown, Lindsay. 2017. "Anthocyanins in chokeberry and purple maize attenuate diet-induced metabolic syndrome in rats." Nutrition. 41, pp. 24-31. https://doi.org/10.1016/j.nut.2016.12.009
A screening method for the detection of fungi with potentially antimicrobial secondary metabolites
Boddington, Morwenna, Kotiw, Michael and Dearnaley, John. 2008. "A screening method for the detection of fungi with potentially antimicrobial secondary metabolites." ASM 2008: Changing Times. Melbourne, Australia 06 - 10 Jul 2008 Melbourne, Australia.
Proteolytic processing of the cilium adhesin MHJ_0194 (P123J ) in Mycoplasma hyopneumoniae generates a functionally diverse array of cleavage fragments that bind multiple host molecules
Raymond, Benjamin B. A., Jenkins, Cheryl, Seymour, Lisa M., Tacchi, Jessica L., Widjaja, Michael, Jarocki, Veronica M., Deutscher, Ania T., Turnbull, Lynne, Whitchurch, Cynthia B., Padula, Matthew P. and Djordjevic, Steven P.. 2014. "Proteolytic processing of the cilium adhesin MHJ_0194 (P123J ) in Mycoplasma hyopneumoniae generates a functionally diverse array of cleavage fragments that bind multiple host molecules." Cellular Microbiology. 17 (3), pp. 425-444. https://doi.org/10.1111/cmi.12377
Green and black cardamom in a diet-induced rat model of metabolic syndrome
Bhaswant, Maharshi, Poudyal, Hemant, Mathai, Michael L., Ward, Leigh C., Mouatt, Peter and Brown, Lindsay. 2015. "Green and black cardamom in a diet-induced rat model of metabolic syndrome." Nutrients. 7 (9), pp. 7691-7707. https://doi.org/10.3390/nu7095360
Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus
Henningham, Anna, Yamaguchi, Masaya, Aziz, Ramy K., Kuipers, Kirsten, Buffalo, Cosmo Z., Dahesh, Samira, Choudhury, Biswa, Van Vleet, Jeremy, Yamaguchi, Yuka, Seymour, Lisa M., Ben Zakour, Nouri L., He, Lingjun, Smith, Helen V., Grimwood, Keith, Beatson, Scott A., Ghosh, Partho, Walker, Mark J., Nizet, Victor and Cole, Jason N.. 2014. "Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus." Journal of Biological Chemistry. 289 (46), pp. 32303-32315. https://doi.org/10.1074/jbc.M114.602847
Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae
Seymour, Lisa M., Falconer, Linda, Deutscher, Ania T., Minion, F. Chris, Padula, Matthew P., Dixon, Nicholas E., Djordjevic, Steven P. and Walker, Mark J.. 2011. "Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae." Journal of Biological Chemistry. 286 (12), pp. 10097-10104. https://doi.org/10.1074/jbc.M110.208140
Mhp182 (P102) binds fibronectin and contributes to the recruitment of plasmin(ogen) to the Mycoplasma hyopneumoniae cell surface
Seymour, Lisa M., Jenkins, Cheryl, Deutscher, Ania T., Raymond, Benjamin B. A., Padula, Matthew P., Tacchi, Jessica L., Bogema, Daniel R., Eamens, Graeme J., Woolley, Lauren K., Dixon, Nicholas E., Walker, Mark J. and Djordjevic, Steven P.. 2012. "Mhp182 (P102) binds fibronectin and contributes to the recruitment of plasmin(ogen) to the Mycoplasma hyopneumoniae cell surface." Cellular Microbiology. 14 (1), pp. 81-94. https://doi.org/10.1111/j.1462-5822.2011.01702.x
Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which mycoplasma hyopneumoniae regulates surface topography
Bogema, Daniel R., Deutscher, Ania T., Woolley, Lauren K., Seymour, Lisa M., Raymond, Benjamin B. A., Tacchi, Jessica L., Padula, Matthew P., Dixon, Nicholas E., Minion, F. Chris, Jenkins, Cheryl, Walker, Mark J. and Djordjevic, Steven P.. 2012. "Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which mycoplasma hyopneumoniae regulates surface topography." mBio. 3 (2), pp. 1-12. https://doi.org/10.1128/mBio.00282-11
Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia
Deutscher, Ania T., Jenkins, Cheryl, Minion, F. Chris, Seymour, Lisa M., Padula, Matthew P., Dixon, Nicholas E., Walker, Mark J. and Djordjevic, Steven P.. 2010. "Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia." Molecular Microbiology. 78 (2), pp. 444-458. https://doi.org/10.1111/j.1365-2958.2010.07345.x
A processed multidomain hyopneumoniae adhesin binds fibronectin, plasminogen and swine respiratory cilia
Seymour, Lisa M., Deutscher, Ania T., Jenkins, Cheryl, Kuit, Tracey A., Falconer, Linda, Minion, F. Chris, Crossett, Ben, Padula, Matthew, Dixon, Nicholas E., Djordjevic, Steven P. and Walker, Mark J.. 2010. "A processed multidomain hyopneumoniae adhesin binds fibronectin, plasminogen and swine respiratory cilia." Journal of Biological Chemistry. 285 (44), pp. 33971-33978. https://doi.org/10.1074/jbc.M110.104463
The globally disseminated M1T1 clone of Group A streptococcus evades autophagy for intracellular replication
Barnett, Timothy C., Liebl, David, Seymour, Lisa M., Gillen, Christine M., Yan Lim, Jin, LaRock, Christopher N., Davies, Mark R., Schulz, Benjamin L., Nizet, Victor, Teasdale, Rohan D. and Walker, Mark J.. 2013. "The globally disseminated M1T1 clone of Group A streptococcus evades autophagy for intracellular replication." Cell Host and Microbe. 14 (6), pp. 675-682. https://doi.org/10.1016/j.chom.2013.11.003
The diversity and antimicrobial activity of Preussia sp. Endophytes isolated from Australian dry rainforests
Mapperson, Rachel R., Kotiw, Michael, Davis, Rohan A. and Dearnaley, John D. W.. 2014. "The diversity and antimicrobial activity of Preussia sp. Endophytes isolated from Australian dry rainforests." Current Microbiology: an international journal. 68 (1), pp. 30-37. https://doi.org/10.1007/s00284-013-0415-5
Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model
Kotiw, Michael, Johnson, Megan, Pandey, Manisha, Fry, Scott, Hazell, Stuart L., Netter, Hans J., Good, Michael F. and Olive, Colleen. 2012. "Immunological response to parenteral vaccination with recombinant hepatitis B virus surface antigen virus-like particles expressing Helicobacter pylori KatA epitopes in a murine H. pylori challenge model ." Clinical and Vaccine Immunology. 19 (2), pp. 268-276. https://doi.org/10.1128/CVI.05295-11
Ravenic acid, a new tetramic acid isolated from a cultured microfungus, penicillium sp.
Michael, Adam P., Grace, Emily J., Kotiw, Mike and Barrow, Russell A.. 2002. "Ravenic acid, a new tetramic acid isolated from a cultured microfungus, penicillium sp." Journal of Natural Products. 65 (9), pp. 1360-1362. https://doi.org/10.1021/np0200358
Xanthones from a microfungus of the genus Xylaria
Healy, Peter C., Hocking, Ailsa, Tran-Dinh, Nai, Pitt, John I., Shivas, Roger G., Mitchell, Jennifer K., Kotiw, Mike and Davis, Rohan A.. 2004. "Xanthones from a microfungus of the genus Xylaria." Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology. 65 (16), pp. 2373-2378. https://doi.org/10.1016/j.phytochem.2004.07.019
Phomoxins B and C: polyketides from an endophytic fungus of the genus eupenicillium
Davis, Rohan A., Andjic, Vesna, Kotiw, Michael and Shivas, Roger G.. 2005. "Phomoxins B and C: polyketides from an endophytic fungus of the genus eupenicillium." Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology. 66 (23), pp. 2771-2775. https://doi.org/10.1016/j.phytochem.2005.09.004
A RAPD-PCR genotyping assay which correlates with serotypes of group B streptococci
Zhang, G. W., Kotiw, M. and Daggard, G.. 2002. "A RAPD-PCR genotyping assay which correlates with serotypes of group B streptococci." Letters in Applied Microbiology. 35 (3), pp. 247-250. https://doi.org/10.1046/j.1472-765X.2002.01177.x
Late-onset and recurrent neonatal group B streptococcal disease associated with breast milk transmission
Kotiw, Michael, Zhang, Gwang W., Daggard, Grant, Reiss-Levy, Elizabeth, Tapsall, John W. and Numa, Andrew. 2003. "Late-onset and recurrent neonatal group B streptococcal disease associated with breast milk transmission." Pediatric and Developmental Pathology. 6 (3), pp. 251-256. https://doi.org/10.1007/s10024-001-0276-y
Synthesis of the fungal natural product (-)-xylariamide A
Kotiw, Michael and Davis, Rohan A.. 2005. "Synthesis of the fungal natural product (-)-xylariamide A." Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry. 46 (31), pp. 5199-5201. https://doi.org/10.1016/j.tetlet.2005.05.114
Caelestines A-D, Brominated Quinolinecarboxylic Acids from the Australian Ascidian Aplidium caelestis
Yin, Sheng, Boyle, Glen M., Carroll, Anthony R., Kotiw, Michael, Dearnaley, John, Quinn, Ronald J. and Davis, Rohan A.. 2010. "Caelestines A-D, Brominated Quinolinecarboxylic Acids from the Australian Ascidian Aplidium caelestis." Journal of Natural Products. 73 (9), pp. 1586-1589. https://doi.org/10.1021/np100329w
Detection of anti-TNFα activity in canine hyperimmune serum using a TNFα inhibition assay
Kotiw, Michael, Morgan, Michael, Taylor, Stephen M. and Shiels, Ian A.. 2010. "Detection of anti-TNFα activity in canine hyperimmune serum using a TNFα inhibition assay ." Veterinary Clinical Pathology. 39 (1), pp. 46-52. https://doi.org/10.1111/j.1939-165X.2009.00166.x
Anti-inflammatory activity of hyperimmune plasma in a lipopolysaccharide-mediated rat air pouch model of inflammation
Essien, Bryan E. and Kotiw, Michael. 2012. "Anti-inflammatory activity of hyperimmune plasma in a lipopolysaccharide-mediated rat air pouch model of inflammation." Inflammation. 35 (1), pp. 58-64. https://doi.org/10.1007/s10753-010-9289-x
Effect of canine hyperimmune plasma on TNFa and inflammatory cell levels in a lipopolysaccharide-mediated rat air pouch model of inflammation
Strunin, Dmitry, Essien, Bryan, Kotiw, Michael and Butler, Harry. 2009. "Effect of canine hyperimmune plasma on TNFa and inflammatory cell levels in a lipopolysaccharide-mediated rat air pouch model of inflammation." Reinhart, Konrad (ed.) Sepsis 2009: Critical Care Conference. Amsterdam, Netherlands 11 - 14 Nov 2009 https://doi.org/10.1186/cc8064
A mathematical model to account for quantitative iterative effect of TNF-α positive feedback mechanism on inflammatory cascade in TLR-4 mediated TNF-α signaling pathway
Roberts, Tony, Essien, Bryan, Kotiw, Michael, Butler, Harry and Strunin, Dmitry. 2008. "A mathematical model to account for quantitative iterative effect of TNF-α positive feedback mechanism on inflammatory cascade in TLR-4 mediated TNF-α signaling pathway." Ragan, Mark (ed.) 19th International Conference on Genome Informatics (GIW 2008). Gold Coast, Australia 01 - 03 Dec 2008 London, United Kingdom.
In vitro effect of canine hyperimmune sera on TNFa activity
Kotiw, Michael, Shiels, I. A., Wilson, R. P. and Reeve-Johnson, Lloyd. 2006. "In vitro effect of canine hyperimmune sera on TNFa activity." Journal of Veterinary Pharmacology and Therapeutics. 29 (Supplement 1), pp. 100-101. https://doi.org/10.1111/j.1365-2885.2006.00761.x
The effect of equine hyperimmune sera on TNF alpha activity in a L929 cell bioassay
Kotiw, M., Raghaven, C., Johnson, M., Shiels, I. A. and Wilson, R. P.. 2006. "The effect of equine hyperimmune sera on TNF alpha activity in a L929 cell bioassay." Bryden, W. L. (ed.) AESS 2006: Australian Equine Science Symposium: Research for the 21st Century Horse Industry: From Genomics to the Winning Post. Gold Coast, Australia 13 - 14 Jun 2006 Gold Coast, Australia.
Biological methods: a novel course in undergraduate biology
Kotiw, Michael, Learmonth, Robert P. and Sutherland, Mark W.. 1999. "Biological methods: a novel course in undergraduate biology." Biochemical Education. 27 (3), pp. 131-134. https://doi.org/10.1016/S0307-4412(99)00002-3
The relevance of human rights to health status in Australian Aboriginal and Torres Strait Islander communities
Smallwood, Gracelyn, White, Colin and Kotiw, Michael. 1997. "The relevance of human rights to health status in Australian Aboriginal and Torres Strait Islander communities." Health and Human Rights: an international journal. 2 (2), pp. 127-136.
In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin
Kotiw, Michael, Morgan, Michael, Lopez, Jesus, Taylor, Steven and Shiels, Ian. 2007. "In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin." Marshall, John (ed.) SEPSIS 2007: International Sepsis Forum ISF . Paris, France 26 - 29 Sep 2007 London, United Kingdom. https://doi.org/10.1186/cc6002
In the footsteps of Florey: utilising cultured microfungi in the search for new antibiotics
Parker, C., Barrow, Russell, Bloor, S. J., Grace, Emily J., Michael, Adam P., Thompson, Christopher and Kotiw, Michael. 2001. "In the footsteps of Florey: utilising cultured microfungi in the search for new antibiotics." Bernhardt, Debra (ed.) FACS 2001: 9th Asian Chemical Congress . Brisbane, Australia 02 - 04 Jul 2001 Brisbane, Australia.
Exploring the potential for dual vaccination against Hepatitis B virus and Helicobacter pylori using a recombinant virus like particle
Kotiw, Michael, Olive, C., Johnson, Megan, Pandy, M., Fry, Scott Robert, Hazell, Stuart L., Netter, H. and Good, M.. 2006. "Exploring the potential for dual vaccination against Hepatitis B virus and Helicobacter pylori using a recombinant virus like particle." Sirtori, Patrizia (ed.) 6th National Congress of the Italian Society of Virology - a joint meeting with the Virus Group of the Society for General Microbiology (UK). Orvieto, Italy 18 - 20 Sep 2006 Italy.
Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp.
Michael, Adam P., Grace, Emily J., Kotiw, Michael and Barrow, Russell A.. 2003. "Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp." Australian Journal of Chemistry: an international journal for chemical science. 56 (1), pp. 13-15. https://doi.org/10.1071/CH02021