Physiological and metabolic effects of yellow mangosteen (Garcinia dulcis) rind in rats with food-induced metabolic syndrome
Article
Article Title | Physiological and metabolic effects of yellow mangosteen (Garcinia dulcis) rind in rats with food-induced metabolic syndrome |
---|---|
ERA Journal ID | 41930 |
Article Category | Article |
Authors | John, Oliver D. (Author), Mouatt, Peter (Author), Majzoub, Marwan E. (Author), Thomas, Torsten (Author), Panchal, Sunil K. (Author) and Brown, Lindsay (Author) |
Journal Title | International Journal of Molecular Sciences |
Journal Citation | 21 (1), pp. 1-29 |
Article Number | 272 |
Number of Pages | 29 |
Year | 2019 |
Publisher | MDPI AG |
Place of Publication | Switzerland |
ISSN | 1422-0067 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/ijms21010272 |
Web Address (URL) | https://www.mdpi.com/1422-0067/21/1/272 |
Abstract | Metabolic syndrome is a cluster of disorders that increase the risk of cardiovascular disease and diabetes. This study has investigated the responses to rind of yellow mangosteen (Garcinia dulcis), usually discarded as waste, in a rat model of human metabolic syndrome. The rind contains higher concentrations of phytochemicals (such as garcinol, morelloflavone and citric acid) than the pulp. Male Wistar rats aged 8–9 weeks were fed either corn starch diet or high-carbohydrate, high-fat diet for 16 weeks, which were supplemented with 5% freeze-dried G. dulcis fruit rind powder during the last 8 weeks. We characterised metabolic, cardiovascular, liver and gut microbiota parameters. High-carbohydrate, high-fat diet-fed rats developed abdominal obesity, hypertension, increased left ventricular diastolic stiffness, decreased glucose tolerance, fatty liver and reduced Bacteroidia with increased Clostridia in the colonic microbiota. G. dulcis fruit rind powder attenuated these changes, improved cardiovascular and liver structure and function, and attenuated changes in colonic microbiota. G. dulcis fruit rind powder may be effective in metabolic syndrome by appetite suppression, inhibition of inflammatory processes and increased fat metabolism, possibly related to changes in the colonic microbiota. Hence, we propose the use of G. dulcis fruit rind as a functional food to ameliorate symptoms of metabolic syndrome. |
Keywords | metabolic syndrome; Garcinia dulcis; citric acid; garcinol; morelloflavone; microbiota |
ANZSRC Field of Research 2020 | 321004. Nutritional science |
321401. Basic pharmacology | |
Byline Affiliations | Functional Foods Research Group |
Southern Cross University | |
University of New South Wales | |
Open access url | https://www.mdpi.com/1422-0067/21/1/272 |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q58vx/physiological-and-metabolic-effects-of-yellow-mangosteen-garcinia-dulcis-rind-in-rats-with-food-induced-metabolic-syndrome
Download files
Published Version
Yellow mangosteen in metabolic syndrome.pdf | ||
License: CC BY 4.0 | ||
File access level: Anyone |
163
total views76
total downloads3
views this month2
downloads this month