Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat
Article
Article Title | Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat |
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ERA Journal ID | 14870 |
Article Category | Article |
Authors | Campbell, Fiona (Author), Atwell, Rick (Author), Fenning, Andrew (Author), Hoey, Andrew (Author) and Brown, Lindsay (Author) |
Journal Title | Toxicon |
Journal Citation | 43 (7), pp. 743-750 |
Number of Pages | 8 |
Year | 2004 |
Place of Publication | United Kingdom |
ISSN | 0041-0101 |
1879-3150 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.toxicon.2004.02.025 |
Web Address (URL) | http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235178%232004%23999569992%23512225%23FLA%23&_cdi=5178&_pubType=J&_auth=y&_acct=C000052720&_version=1&_urlVersion=0&_userid=1472215&md5=c99454dfdc7bb636708b0d4517906e98 |
Abstract | [Abstract]: An extract of toxin(s) from the Australian paralysis tick, Ixodes holocyclus, produced positive inotropic responses in rat left ventricular papillary muscles and positive contractile responses in rat thoracic aortic rings. There was no measurable chronotropic response in rat right atria, but positive inotropic concentrations in papillary muscles produced arrhythmias in right atria. Positive inotropic responses were attenuated by verapamil, but unaffected by metoprolol, cimetidine, pyrilamine, tetrodotoxin and pinacidil. Microelectrode studies on isolated left ventricular papillary muscles demonstrated that the extract |
Keywords | Australian paralysis tick toxin; cardiovascular responses; Ixodes holocyclus |
ANZSRC Field of Research 2020 | 310999. Zoology not elsewhere classified |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of Queensland |
Centre for Biomedical Research | |
Department of Biological and Physical Sciences |
https://research.usq.edu.au/item/9zw21/cardiovascular-effects-of-the-toxin-s-of-the-australian-paralysis-tick-ixodes-holocyclus-in-the-rat
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