Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats

Article

Mesripour, Azadeh, Iyer, Abishek and Brown, Lindsay. 2012. "Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats." Basic and Clinical Pharmacology and Toxicology. 111 (2), pp. 75-80. https://doi.org/10.1111/j.1742-7843.2012.00860.x

Article Title	Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats
ERA Journal ID	14693
Article Category	Article
Authors	Mesripour, Azadeh (Author), Iyer, Abishek (Author) and Brown, Lindsay (Author)
Journal Title	Basic and Clinical Pharmacology and Toxicology
Journal Citation	111 (2), pp. 75-80
Number of Pages	6
Year	2012
Place of Publication	Oxford, United Kingdom
ISSN	0901-9928
	1742-7835
	1742-7843
Digital Object Identifier (DOI)	https://doi.org/10.1111/j.1742-7843.2012.00860.x
Web Address (URL)	http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2012.00860.x/pdf
Abstract	Acute morphine administration decreases cardiac responses to ischaemic injury. This project has determined whether induction of morphine dependence in rats by gradually increasing morphine doses for 21 days induces structural and functional changes in the cardiovascular system because of mineralocorticoid receptor activation, as morphine increases plasma corticosterone concentrations. Morphine-dependent rats showed ventricular hypertrophy, increased collagen deposition in the left ventricle together with an increased ventricular stiffness and increased plasma malondialdehyde concentrations without changes in systolic blood pressure or thoracic aortic responsiveness. These parameters were attenuated or normalised in morphine-dependent rats treated with spironolactone (50 mg/kg/day) from days 14–21. These results suggest that morphine dependence induces ventricular remodelling and increased oxidative stress that can be prevented by the mineralocorticoid receptor antagonist, spironolactone.
Keywords	opiates; heart attack; cardiac remodelling; blood pressure
ANZSRC Field of Research 2020	321405. Pharmaceutical sciences
	320101. Cardiology (incl. cardiovascular diseases)
	320699. Medical biotechnology not elsewhere classified
Public Notes	Files associated with this item cannot be displayed due to copyright restrictions.
Byline Affiliations	Shahrekord University of Medical Sciences, Iran
	University of Queensland
Institution of Origin	University of Southern Queensland

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Gobe, Glenda C., Bennett, Nigel C., West, Malcolm, Colditz, Paul, Brown, Lindsay, Vesey, David A. and Johnson, David W.. 2014. "Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury." American Journal of Physiology: Renal Physiology. 306 (6), pp. F681-F692. https://doi.org/10.1152/ajprenal.00241.2013

Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats

Kumar, Senthil Arun, Magnusson, Marie, Ward, Leigh C., Paul, Nicholas A. and Brown, Lindsay. 2015. "Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats." Marine Drugs. 13 (2), pp. 788-805. https://doi.org/10.3390/md13020788

Nutraceuticals for chronic inflammatory diseases

Brown, Lindsay. 2013. "Nutraceuticals for chronic inflammatory diseases." Journal of the Australian Traditional-Medicine Society. 19 (4), pp. 214-221.

Obesity and metabolic syndrome

Panchal, Sunil K., Bhaswant, Maharshu and Brown, Lindsay. 2014. "Obesity and metabolic syndrome." Vela, Jose M., Maldonado, Rafael and Hamon, Michel (ed.) In vivo models for drug discovery. Weinheim, Germany. John Wiley & Sons. pp. 333-348

Glibenclamide improves kidney and heart structure and function in the adenine-diet model of chronic kidney disease

Diwan, Vishal, Gobe, Glenda and Brown, Lindsay. 2014. "Glibenclamide improves kidney and heart structure and function in the adenine-diet model of chronic kidney disease." Pharmacological Research. 79, pp. 104-110. https://doi.org/10.1016/j.phrs.2013.11.007

Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats

Diwan, Vishal, Small, David, Kauter, Kate, Gobe, Glenda C. and Brown, Lindsay. 2014. "Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats." American Journal of Physiology: Renal Physiology. 307 (11), pp. F1169-F1178. https://doi.org/10.1152/ajprenal.00676.2013

Effects of red pitaya juice supplementation on cardiovascular and hepatic changes in high-carbohydrate, high-fat diet-induced metabolic syndrome rats

Ramli, Nurul Shazini, Brown, Lindsay, Ismail, Patimah and Rahmat, Asmah. 2014. "Effects of red pitaya juice supplementation on cardiovascular and hepatic changes in high-carbohydrate, high-fat diet-induced metabolic syndrome rats." BMC Complementary Medicine and Therapies. 14, pp. 189-198. https://doi.org/10.1186/1472-6882-14-189

Food as medicine [Introduction]

Panchal, Sunil K., Ward, Leigh C. and Brown, Lindsay. 2013. "Food as medicine [Introduction]." Canadian Journal of Physiology and Pharmacology. 91 (6), pp. 503-503. https://doi.org/10.1139/cjpp-2013-0147

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

Lim, Junxian, Iyer, Abishek, Liu, Ligong, Suen, Jacky Y., Lohman, Rink-Jan, Seow, Vernon, Yau, Mei-Kwan, Brown, Lindsay and Fairlie, David P.. 2013. "Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism." The FASEB Journal. 27 (12), pp. 4757-4767. https://doi.org/10.1096/fj.13-232702

Osteoporosis and its association with non-gonadal hormones involved in hypertension, adiposity and hyperglycaemia

Poudyal, Hemant and Brown, Lindsay. 2013. "Osteoporosis and its association with non-gonadal hormones involved in hypertension, adiposity and hyperglycaemia." Current Drug Targets. 14 (14), pp. 1694-1706. https://doi.org/10.2174/1389450119999990001

Seaweeds as potential therapeutic interventions for the metabolic syndrome

Kumar, Senthil Arun and Brown, Lindsay. 2013. "Seaweeds as potential therapeutic interventions for the metabolic syndrome." Reviews in Endocrine and Metabolic Disorders. 14 (3), pp. 299-308. https://doi.org/10.1007/s11154-013-9254-8

Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing

Lau, Dennis H., Shipp, Nicholas J., Kelly, Darren J., Thanigaimani, Shivshankar, Neo, Melissa, Kuklik, Pawel, Lim, Han S., Zhang, Yuan, Drury, Karen, Wong, Christopher X., Chia, Nicholas H., Brooks, Anthony G., Dimitri, Hany, Saint, David A., Brown, Lindsay and Sanders, Prashanthan. 2013. "Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing." PLoS One. 8 (8), pp. 1-9. https://doi.org/10.1371/journal.pone.0072416

Adenine-induced chronic kidney and cardiovascular damage in rats

Diwan, Vishal, Mistry, Anand, Gobe, Glenda and Brown, Lindsay. 2013. "Adenine-induced chronic kidney and cardiovascular damage in rats." Journal of Pharmacological and Toxicological Methods. 68 (2), pp. 197-207. https://doi.org/10.1016/j.vascn.2013.05.006

Chronic l-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats

Alam, Md. Ashraful, Kauter, Kathleen, Withers, Kerry, Sernia, Conrad and Brown, Lindsay. 2013. "Chronic l-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats." Food and Function. 4 (1), pp. 83-91. https://doi.org/10.1039/c2fo30096f

Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats

Alam, Md. Ashraful, Kauter, Kathleen and Brown, Lindsay. 2013. "Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats." Nutrients. 5 (3), pp. 637-650. https://doi.org/10.3390/nu5030637

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

Lim, Junxian, Iyer, Abishek, Suen, Jacky Y., Seow, Vernon, Reid, Robert C., Brown, Lindsay and Fairlie, David P.. 2013. "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling." The FASEB Journal. 27 (2), pp. 822-831. https://doi.org/10.1096/fj.12-220582

Ferulic acid improves cardiovascular and kidney structure and function in hypertensive rats

Alam, Md. Ashraful, Sernia, Conrad and Brown, Lindsay. 2013. "Ferulic acid improves cardiovascular and kidney structure and function in hypertensive rats." Journal of Cardiovascular Pharmacology. 61 (3), pp. 240-249. https://doi.org/10.1097/FJC.0b013e31827cb600

Responses to oleic, linoleic and alpha linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

Poudyal, Hemant, Kumar, Senthil A., Iyer, Aarjit, Waanders, Jennifer, Ward, Leigh C. and Brown, Lindsay. 2013. "Responses to oleic, linoleic and alpha linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats." Journal of Nutritional Biochemistry. 24 (7), pp. 1381-1392. https://doi.org/10.1016/j.jnutbio.2012.11.006

Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

Poudyal, Hemant, Panchal, Sunil K., Ward, Leigh C. and Brown, Lindsay. 2013. "Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats ." Journal of Nutritional Biochemistry. 24 (6), pp. 1041-1052. https://doi.org/10.1016/j.jnutbio.2012.07.014

Tocotrienols as possible treatments for obesity

Wong, Weng-Yew and Brown, Lindsay. 2013. "Tocotrienols as possible treatments for obesity." Tan, Barrie, Watson, Ronald Ross and Preedy, Victor R. (ed.) Tocotrienols: vitamin E beyond tocopherols, 2nd ed.. Boca Raton, FL. United States. CRC Press. pp. 195-208

The role of n-3 polyunsaturated fatty acids in human heart failure

Poudyal, Hemant and Brown, Lindsay. 2013. "The role of n-3 polyunsaturated fatty acids in human heart failure." Endocrine, Metabolic and Immune Disorders: Drug Targets. 13 (1), pp. 105-117. https://doi.org/10.2174/1871530311313010013

Traditional Indian medicines for metabolic syndrome

Diwan, Vishal, Poudyal, Hemant and Brown, Lindsay. 2012. "Traditional Indian medicines for metabolic syndrome." Essa, M. Mohamed, Manickavasagan, A. and Sukumar, E. (ed.) Natural products and their active compounds on disease prevention. Hauppauge, NY. United States . Nova Science Publishers. pp. 1-21

Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats

Wong, Weng-Yew, Poudyal, Hemant, Ward, Leigh C. and Brown, Lindsay. 2012. "Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats." Nutrients. 4 (10), pp. 1527-1541. https://doi.org/10.3390/nu4101527

Endurance exercise in a rat model of metabolic syndrome

Cameron, Isabelle, Alam, Mohammed Ashraful, Wang, Jianxiong and Brown, Lindsay. 2012. "Endurance exercise in a rat model of metabolic syndrome." Canadian Journal of Physiology and Pharmacology. 90 (11), pp. 1490-1497. https://doi.org/10.1139/y2012-097

Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes

Poudyal, Hemant, Panchal, Sunil K., Ward, Leigh C., Waanders, Jennifer and Brown, Lindsay. 2012. "Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes ." American Journal of Physiology: Endocrinology and Metabolism. 302 (12), pp. 1472-1482. https://doi.org/10.1152/ajpendo.00102.2012

Caffeine attenuates metabolic syndrome in diet-induced obese rats

Panchal, Sunil K., Wong, Weng-Yew, Kauter, Kate, Ward, Leigh C. and Brown, Lindsay. 2012. "Caffeine attenuates metabolic syndrome in diet-induced obese rats." Nutrition. 28 (10), pp. 1055-1062. https://doi.org/10.1016/j.nut.2012.02.013

An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats

Iyer, Abishek, Lim, Junxian, Poudyal, Hemant, Reid, Robert C., Suen, Jacky Y., Webster, Julie, Prins, Johannes B., Whitehead, Jonathan P., Fairlie, David P. and Brown, Lindsay. 2012. "An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats." Diabetes. 61 (9), pp. 2320-2329. https://doi.org/10.2337/db11-1179

Lysine acetylation in obesity, diabetes and metabolic disease

Iyer, Abishek, Fairlie, David P. and Brown, Lindsay. 2012. "Lysine acetylation in obesity, diabetes and metabolic disease ." Immunology and Cell Biology. 90 (1), pp. 39-46. https://doi.org/10.1038/icb.2011.99

Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats

Panchal, Sunil K., Poudyal, Hemant, Waanders, Jennifer and Brown, Lindsay. 2012. "Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats ." The Journal of Nutrition. 142 (4), pp. 690-697. https://doi.org/10.3945/jn.111.153577

Lipid redistribution by alpha linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats

Poudyal, Hemant, Panchal, Sunil K., Waanders, Jennifer, Ward, Leigh and Brown, Lindsay. 2012. "Lipid redistribution by alpha linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats." Journal of Nutritional Biochemistry. 23 (2), pp. 153-162. https://doi.org/10.1016/j.jnutbio.2010.11.011

The effects of immunosuppressants on vascular function, systemic oxidative stress and inflammation in rats

Shing, Cecilia M., Fassett, Robert G., Brown, Lindsay and Coombes, Jeff S.. 2012. "The effects of immunosuppressants on vascular function, systemic oxidative stress and inflammation in rats." Transplant International. 25 (3), pp. 337-346. https://doi.org/10.1111/j.1432-2277.2011.01420.x

Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats

Panchal, Sunil K., Poudyal, Hemant and Brown, Lindsay. 2012. "Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats ." The Journal of Nutrition. 142 (6), pp. 1026-1032. https://doi.org/10.3945/jn.111.157263

Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling

Alam, Md. Ashraful, Uddin, Shaikh Jamal and Brown, Lindsay. 2012. "Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling ." Rahman, Atta (ed.) Bioactive natural products. Amsterdam, Netherlands. Elsevier. pp. 159-190

Piperine attenuates cardiovascular, liver and metabolic changes in high carbohydrate, high fat-fed rats

Diwan, Vishal, Poudyal, Hemant and Brown, Lindsay. 2013. "Piperine attenuates cardiovascular, liver and metabolic changes in high carbohydrate, high fat-fed rats ." Cell Biochemistry and Biophysics. 67 (2), pp. 297-304. https://doi.org/10.1007/s12013-011-9306-1

Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

Panchal, Sunil K., Ward, Leigh and Brown, Lindsay. 2013. "Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats." European Journal of Nutrition. 52 (2), pp. 559-568. https://doi.org/10.1007/s00394-012-0358-9

Cardioprotective and hepatoprotective effects of ellagitannins from European oak bark (Quercus petraea L.) extract in rats

Panchal, Sunil K. and Brown, Lindsay. 2013. "Cardioprotective and hepatoprotective effects of ellagitannins from European oak bark (Quercus petraea L.) extract in rats." European Journal of Nutrition. 52 (1), pp. 397-408. https://doi.org/10.1007/s00394-011-0277-1

Gender differences in metabolic syndrome - a key research issue

Iyer, Abishek, Kauter, Kathleen and Brown, Lindsay. 2011. "Gender differences in metabolic syndrome - a key research issue." Endocrine, Metabolic and Immune Disorders: Drug Targets. 11 (3), pp. 182-188.

Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity

Poudyal, Hemant and Brown, Lindsay. 2011. "Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity." Endocrine, Metabolic and Immune Disorders: Drug Targets. 11 (3), pp. 217-231.

Nutrapharmacology of tocotrienols for metabolic syndrome

Wong, Weng-Yew and Brown, Lindsay. 2011. "Nutrapharmacology of tocotrienols for metabolic syndrome ." Current Pharmaceutical Design. 17 (21), pp. 2206-2214. https://doi.org/10.2174/138161211796957445

Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action

Poudyal, Hemant, Panchal, Sunil K., Diwan, Vishal and Brown, Lindsay. 2011. "Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action." Progress in Lipid Research. 50 (4), pp. 372-387. https://doi.org/10.1016/j.plipres.2011.06.003

Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats

Iyer, Abishek, Woodruff, Trent M., Wu, Mike C. L., Stylianou, Con, Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay. 2011. "Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats ." Journal of Cardiovascular Pharmacology. 58 (5), pp. 479-486. https://doi.org/10.1097/FJC.0b013e31822a7a09

Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats

Iyer, Abishek, Kauter, Kathleen, Alam, Md. Ashraful, Hwang, Sung Hee, Morisseau, Christophe, Hammock, Bruce D. and Brown, Lindsay. 2012. "Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats." Experimental Diabetes Research. 2012, pp. 1-11. https://doi.org/10.1155/2012/758614

Chronic b-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat

Chan, Vincent, Fenning, Andrew, Hoey, Andrew and Brown, Lindsay. 2011. "Chronic b-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat." Journal of Cardiovascular Pharmacology. 58 (4), pp. 424-431. https://doi.org/10.1097/FJC.0b013e3182283c78

Coffee and caffeine attenuate symptoms of metabolic syndrome in diet-induced obese rats

Panchal, S. and Brown, L.. 2012. "Coffee and caffeine attenuate symptoms of metabolic syndrome in diet-induced obese rats." 2012 Australian & New Zealand Obesity Society Annual Scientific Meeting. New Zealand 01 Oct 2012 Netherlands. https://doi.org/10.1016/j.orcp.2012.08.039

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes

Wei, Michael, Ong, Leslie, Smith, Maree, Ross, Fraser B., Schmid, Katrina, Hoey, Andrew, Burstow, Darryl and Brown, Lindsay. 2003. "The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes." Heart Lung and Circulation. 12 (1), pp. 44-50. https://doi.org/10.1046/j.1444-2892.2003.00160.x

Attenuation of Cardiovascular Remodeling in DOCA-Salt Rats by the Vasopeptidase Inhibitor, Omapatrilat

Loch, David, Hoey, Andrew and Brown, Lindsay. 2006. "Attenuation of Cardiovascular Remodeling in DOCA-Salt Rats by the Vasopeptidase Inhibitor, Omapatrilat ." Clinical and Experimental Hypertension. 28 (5), pp. 475-488. https://doi.org/10.1080/10641960600798754

Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle

Woolf, Peter James, Lu, Sai, Cornford-Nairn, Renee A., Watson, Michael, Xiao, Xiao-Hui, Holroyd, Sean, Brown, Lindsay and Hoey, Andrew. 2006. "Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle." American Journal of Physiology: Heart and Circulatory Physiology. 290 (6), pp. H2439-H2445. https://doi.org/10.1152/ajpheart.00844.2005

Cardiac extracellular matrix: a dynamic entity

Brown, Lindsay. 2005. "Cardiac extracellular matrix: a dynamic entity." American Journal of Physiology: Heart and Circulatory Physiology. 289 (3), pp. H973-H974. https://doi.org/10.1152/ajpheart.00443.2005

Increased calcium influx mediates increased cardiac stiffness in hyperthyroid rats

Levick, Scott, Fenning, Andrew and Brown, Lindsay. 2005. "Increased calcium influx mediates increased cardiac stiffness in hyperthyroid rats." Cell Biochemistry and Biophysics. 43 (1), pp. 53-60.

Antioxidant supplementation enhances erythrocyte antioxidant status and attenuates cyclosporine-induced vascular dysfunction

Lexis, L. A., Fenning, A., Brown, L., Fassett, R. G. and Coombes, J. S.. 2006. "Antioxidant supplementation enhances erythrocyte antioxidant status and attenuates cyclosporine-induced vascular dysfunction." American Journal of Transplantation. 6 (1), pp. 41-49. https://doi.org/10.1111/j.1600-6143.2005.01154.x

Therapeutic interventions: an Islamic perspective

Rahman, Mohammad Tariqur, Nazer, Reeza, Brown, Lindsay, Shogar, Ibrahim and Bouzenita, Anke Iman. 2008. "Therapeutic interventions: an Islamic perspective." IMA Journal. 40 (2), pp. 60-68.

Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats

Levick, Scott, Loch, David, Rolfe, Barbara E., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay. 2006. "Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats ." Journal of Immunology. 176 (11), pp. 7000-7007.

Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress

Lim, Chin Leong, Wilson, Gary, Brown, Lindsay, Coombes, Jeff S. and Mackinnon, Laurel T.. 2007. "Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress ." American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 292 (1), pp. R186-R194. https://doi.org/10.1152/ajpregu.00921.2005

Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease

Percy, C. J., Brown, Lindsay, Power, D. A., Johnson, David W. and Gobe, Glenda C.. 2009. "Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease." Mechanisms of Ageing and Development. 130 (3), pp. 129-138. https://doi.org/10.1016/j.mad.2008.10.003

Chronic dietary L-arginine down-regulates adenosine receptor and nitric oxide synthase expression in rat heart

Rose'Meyer, Roselyn B., Harrison, Glenn, Fenning, Andrew, Jenner, Tamsin and Brown, Lindsay. 2008. "Chronic dietary L-arginine down-regulates adenosine receptor and nitric oxide synthase expression in rat heart." Basic and Clinical Pharmacology and Toxicology. 102 (5), pp. 459-465. https://doi.org/10.1111/j.1742-7843.2008.00209.x

Resistance to ocular antibiotics: an overview

Brown, Lindsay. 2007. "Resistance to ocular antibiotics: an overview ." Clinical and Experimental Optometry. 90 (4), pp. 258-262. https://doi.org/10.1111/j.1444-0938.2007.00154.x

Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats

Panchal, Sunil K., Poudyal, Hemant, Arumugam, Thiruma V. and Brown, Lindsay. 2011. "Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats ." The Journal of Nutrition. 141 (6), pp. 1062-1069. https://doi.org/10.3945/jn.111.137877

High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats

Panchal, Sunil K., Poudyal, Hemant, Iyer, Abishek, Nazer, Reeza, Alam, Md. Ashraful, Diwan, Vishal, Kauter, Kathleen, Sernia, Conrad, Campbell, Fiona, Ward, Leigh, Gobe, Glenda, Fenning, Andrew and Brown, Lindsay. 2011. "High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats." Journal of Cardiovascular Pharmacology. 57 (5), pp. 611-624. https://doi.org/10.1097/FJC.0b013e3181feb90a

A regenerative antioxidant protocol of vitamin E and alpha-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats

Patel, Jatin, Matnor, Nur Azim, Iyer, Abishek and Brown, Lindsay. 2011. "A regenerative antioxidant protocol of vitamin E and alpha-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats." Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2011/120801

Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats

Chan, Vincent, Fenning, Andrew, Levick, Scott P., Loch, David, Chunduri, Prasad, Iyer, Abishek, Teo, Yi Ling, Hoey, Andrew, Wilson, Kathleen, Burstow, Darryl and Brown, Lindsay. 2011. "Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats." Journal of Cardiovascular Pharmacology. 57 (4), pp. 469-478. https://doi.org/10.1097/FJC.0b013e3182102c3b

Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats

Chan, Vincent, Fenning, Andrew, Iyer, Abishek, Hoey, Andrew and Brown, Lindsay. 2011. "Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats." Current Pharmaceutical Biotechnology. 12 (3), pp. 429-436. https://doi.org/10.2174/138920111794480552

Rodent models for metabolic syndrome research

Panchal, Sunil K. and Brown, Lindsay. 2011. "Rodent models for metabolic syndrome research." Journal of Biomedicine and Biotechnology. https://doi.org/10.1155/2011/351982

Comparison of purple carrot juice and b-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome

Poudyal, Hemant, Panchal, Sunil and Brown, Lindsay. 2010. "Comparison of purple carrot juice and b-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome." The British Journal of Nutrition: an international journal of nutritional science. 104 (9), pp. 1322-1332. https://doi.org/10.1017/S0007114510002308

Lipid mediators and inflammation in glucose intolerance and insulin resistance

Iyer, Abishek and Brown, Lindsay. 2010. "Lipid mediators and inflammation in glucose intolerance and insulin resistance." Drug Discovery Today: Disease Mechanisms. 7 (3-4), pp. e191-e197. https://doi.org/10.1016/j.ddmec.2010.12.001

The DOCA-salt hypertensive rat as a model of cardiovascular oxidative and inflammatory stress

Iyer, Abishek, Chan, Vincent and Brown, Lindsay. 2010. "The DOCA-salt hypertensive rat as a model of cardiovascular oxidative and inflammatory stress." Current Cardiology Reviews. 6 (4), pp. 291-297. https://doi.org/10.2174/157340310793566109

Green tea attenuates cardiovascular remodeling and metabolic symptoms in high carbohydrate-fed rats

Rickman, Celestine, Iyer, Abishek, Chan, Vincent and Brown, Lindsay. 2010. "Green tea attenuates cardiovascular remodeling and metabolic symptoms in high carbohydrate-fed rats." Current Pharmaceutical Biotechnology. 11 (8), pp. 881-886.

The cardiovascular nutrapharmacology of resveratrol: pharmacokinetics, molecular mechanisms and therapeutic potential

Kroon, Paul A., Iyer, Abishek, Chunduri, Prasad, Chan, Vincent and Brown, Lindsay. 2010. "The cardiovascular nutrapharmacology of resveratrol: pharmacokinetics, molecular mechanisms and therapeutic potential ." Current Medicinal Chemistry. 17 (23), pp. 2442-2455. https://doi.org/10.2174/092986710791556032

L-carnitine attenuates cardiac impairment but not vascular dysfunction in DOCA-salt hypertensive rats

O'Brien, Daniel, Chunduri, Prasad, Iyer, Abishek and Brown, Lindsay. 2010. "L-carnitine attenuates cardiac impairment but not vascular dysfunction in DOCA-salt hypertensive rats ." Basic and Clinical Pharmacology and Toxicology. 106 (4), pp. 296-301. https://doi.org/10.1111/j.1742-7843.2009.00480.x

Rutin attenuates non-alcoholic steatohepatitis in high carbohydrate-high fat diet-fed rats

Panchal, S. K., Poudyal, H., Arumugam, T. V. and Brown, L.. 2011. "Rutin attenuates non-alcoholic steatohepatitis in high carbohydrate-high fat diet-fed rats." 46th Annual Meeting of the European Association for the Study of the Liver. Berlin 30 Mar - 03 Apr 2011 Netherlands. https://doi.org/10.1016/S0168-8278(11)60097-4

Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2

Herath, Chandana B., Lubel, John S., Jia, Zhiyuan, Velkoska, Elena, Casley, David, Brown, Lindsay, Tikellis, Chris, Burrell, Louise M. and Angus, Peter W.. 2009. "Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2." American Journal of Physiology: Gastrointestinal and Liver Physiology. 297 (1), pp. G98-G106. https://doi.org/10.1152/ajpgi.00045.2009

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats: research paper

Iyer, Abishek, Fenning, Andrew, Lim, Junxian, Le, Giang T., Reid, Robert C., Halili, Maria A., Fairlie, David P. and Brown, Lindsay. 2010. "Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats: research paper." British Journal of Pharmacology. 159 (7), pp. 1408-1417. https://doi.org/10.1111/j.1476-5381.2010.00637.x

Inflammatory lipid mediators in adipocyte function and obesity

Iyer, Abishek, Prins, Johannes B., Fairlie, David P., Hammock, Bruce D. and Brown, Lindsay. 2010. "Inflammatory lipid mediators in adipocyte function and obesity." Nature Reviews Endocrinology. 6 (2), pp. 71-82. https://doi.org/10.1038/nrendo.2009.264

Is mycophenolate more than just an immunosuppressant? An overview

Iyer, Abishek and Brown, Lindsay. 2009. "Is mycophenolate more than just an immunosuppressant? An overview." Indian Journal of Biochemistry and Biophysics. 46 (1), pp. 25-30.

Evaluation of the chronic complications of diabetes in a high fructose diet in rats

Patel, Jatin, Iyer, Abishek and Brown, Lindsay. 2009. "Evaluation of the chronic complications of diabetes in a high fructose diet in rats." Indian Journal of Biochemistry and Biophysics. 46 (1), pp. 66-72.

The biological responses to resveratrol and other polyphenols from alcoholic beverages

Brown, Lindsay, Kroon, Paul A., Das, Dipak K., Das, Samarjit, Tosaki, Arpad, Chan, Vincent, Singer, Manfred V. and Feick, Peter. 2009. "The biological responses to resveratrol and other polyphenols from alcoholic beverages." Alcoholism: Clinical and Experimental Research. 33 (9), pp. 1513-1523. https://doi.org/10.1111/j.1530-0277.2009.00989.x

Potential health benefits of Indian spices in the symptoms of metabolic syndrome: a review

Iyer, Abishek, Panchal, Sunil, Poudyal, Hemant and Brown, Lindsay. 2009. "Potential health benefits of Indian spices in the symptoms of metabolic syndrome: a review." Indian Journal of Biochemistry and Biophysics. 46 (6), pp. 467-481.

Fermented wheat germ extract extract (Avemar) in the treatment of cardiac remodelling and metabolic symptoms in rats

Iyer, Abishek and Brown, Lindsay. 2009. "Fermented wheat germ extract extract (Avemar) in the treatment of cardiac remodelling and metabolic symptoms in rats." Evidence-Based Complementary and Alternative Medicine. 2011, pp. 1-9. https://doi.org/10.1093/ecam/nep090

Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat

Campbell, Fiona, Atwell, Rick, Fenning, Andrew, Hoey, Andrew and Brown, Lindsay. 2004. "Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat." Toxicon. 43 (7), pp. 743-750. https://doi.org/10.1016/j.toxicon.2004.02.025

Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats

Poudyal, Hemant, Campbell, Fiona and Brown, Lindsay. 2010. "Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats." The Journal of Nutrition. 140 (5), pp. 946-953. https://doi.org/10.3945/jn.109.117812

Rosuvastatin attenuates heart failure and cardiac remodelling in the ageing spontaneously hypertensive rat

Loch, David, Chan, Vincent, Hoey, Andrew and Brown, Lindsay. 2009. "Rosuvastatin attenuates heart failure and cardiac remodelling in the ageing spontaneously hypertensive rat." Basic and Clinical Pharmacology and Toxicology. 105 (4), pp. 262-270. https://doi.org/10.1111/j.1742-7843.2009.00440.x

Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase

Loch, David, Hoey, Andrew, Morisseau, Christophe, Hammock, Bruce O. and Brown, Lindsay. 2007. "Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase." Cell Biochemistry and Biophysics. 47 (1), pp. 87-98.

Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats

Loch, David, Levick, Scott, Hoey, Andrew and Brown, Lindsay. 2006. "Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats." Journal of Cardiovascular Pharmacology. 47 (3), pp. 396-404.

Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats

Chan, Vincent, Hoey, Andrew and Brown, Lindsay. 2006. "Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats." British Journal of Pharmacology. 148 (7), pp. 902-908. https://doi.org/10.1038/sj.bjp.0706801

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats

Fenning, Andrew, Harrison, Glenn, Rose'Meyer, Roselyn, Hoey, Andrew and Brown, Lindsay. 2005. "L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats." American Journal of Physiology: Heart and Circulatory Physiology. 289 (4), pp. H1408-H1416. https://doi.org/10.1152/ajpheart.00140.2005

Reversal of cardiac dysfunction by selective ET-A receptor antagonism

Allan, Anthony, Fenning, Andrew, Levick, Scott, Hoey, Andrew and Brown, Lindsay. 2005. "Reversal of cardiac dysfunction by selective ET-A receptor antagonism." British Journal of Pharmacology. 146 (6), pp. 846-853. https://doi.org/10.1038/sj.bjp.0706384

Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats

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