Nutraceuticals in rodent models as potential treatments for human Inflammatory Bowel Disease
Article
Article Title | Nutraceuticals in rodent models as potential treatments for human Inflammatory Bowel Disease |
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ERA Journal ID | 14840 |
Article Category | Article |
Authors | Ghattamaneni, Naga K. R. (Author), Panchal, Sunil K. (Author) and Brown, Lindsay (Author) |
Journal Title | Pharmacological Research |
Journal Citation | 132, pp. 99-107 |
Number of Pages | 9 |
Year | 2018 |
Place of Publication | United Kingdom |
ISSN | 1043-6618 |
1096-1186 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.phrs.2018.04.015 |
Web Address (URL) | https://www.sciencedirect.com/science/article/abs/pii/S1043661817314482 |
Abstract | Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation of all or part of the digestive tract. Nutraceuticals include bioactive compounds such as polyphenols with anti-inflammatory activities, thus these products have the potential to treat chronic inflammatory diseases. We have emphasized the role of nutraceuticals in ameliorating the symptoms of IBD in rodent models of human IBD through modulation of key pathogenic mechanisms including dysbiosis, oxidative stress, increased inflammatory cytokines, immune system dysregulation, and inflammatory cell signaling pathways. Nutraceuticals have an important role in IBD patients as a preventive approach to extend remission phases and as a therapeutic intervention to suppress active IBD. Further clinical trials on nutraceuticals with positive results in rodent models are warranted. |
Keywords | Inflammatory Bowel Disease, inflammation, gut microbiota, polyphenols, cytokines |
ANZSRC Field of Research 2020 | 321004. Nutritional science |
321401. Basic pharmacology | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Centre for Health Research |
Institute for Agriculture and the Environment | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q4qq3/nutraceuticals-in-rodent-models-as-potential-treatments-for-human-inflammatory-bowel-disease
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