Cardioprotective and hepatoprotective effects of natural products in metabolic syndrome
PhD Thesis
Title | Cardioprotective and hepatoprotective effects of natural products in metabolic syndrome |
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Type | PhD Thesis |
Authors | |
Author | Panchal, Sunil K. |
Supervisor | Brown, Lindsay |
Institution of Origin | University of Southern Queensland |
Qualification Name | Doctor of Philosophy |
Number of Pages | 322 |
Year | 2012 |
Abstract | The prevalence of metabolic syndrome is increasing throughout the world. Metabolic syndrome is the clustering of risk factors for cardiovascular disease and type 2 diabetes. These include obesity, hypertension, impaired Nature has provided us with immense diversity in the form of plants and herbs, which contain a wide range of chemicals. Development of natural products as a potential treatment for metabolic syndrome requires a suitable High-carbohydrate, high-fat diet induced hypertension, obesity, impaired glucose tolerance, dyslipidaemia, cardiovascular remodelling including ventricular dilatation, cardiomyocyte hypertrophy and cardiac Rutin and quercetin ameliorated these cardiovascular and hepatic changes and attenuated impairment in glucose tolerance and hypertension whereas only rutin improved obesity and dyslipidaemia. Ellagitannins from oak These effects differed from caffeine, which reduced total body fat, body weight and abdominal fat, along with the attenuation of symptoms of metabolic syndrome, cardiovascular remodelling and non-alcoholic steatohepatitis. ʟ-Carnitine, a transporter of fatty acid across mitochondrial membrane, attenuated the metabolic syndrome by increasing β-oxidation and decreasing lipogenesis in both the heart and the liver. In humans, fatty liver is caused by the excess consumption of diets rich in ethanol, animal fats, simple carbohydrates such as fructose or a combination of all three. An initiative was taken to mimic the combined effects of highcarbohydrate, high-fat diet and ethanol in rats as in human fatty liver disease. Ethanol synergistically aggravated hepatic steatosis induced by highcarbohydrate, These studies clearly indicate the potential present in many natural products. The mechanisms of action of these natural products were also different as some of them reduced abdominal fat, possibly due to increased |
Keywords | metabolic syndrome; obesity; non-alcoholic fatty liver disease; cardiovascular remodelling; natural products; high-carbohydrate, high-fat diet; polyphenols; dyslipidaemia; hypertension; impaired glucose tolerance |
ANZSRC Field of Research 2020 | 420899. Traditional, complementary and integrative medicine not elsewhere classified |
320507. Metabolic medicine | |
321401. Basic pharmacology | |
320699. Medical biotechnology not elsewhere classified | |
Byline Affiliations | Department of Biological and Physical Sciences |
https://research.usq.edu.au/item/q1xy2/cardioprotective-and-hepatoprotective-effects-of-natural-products-in-metabolic-syndrome
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