Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats
Article
Article Title | Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats |
---|---|
ERA Journal ID | 13734 |
Article Category | Article |
Authors | Bhandarkar, Nikhil S. (Author), Brown, Lindsay (Author) and Panchal, Sunil K. (Author) |
Journal Title | Nutrition Research |
Journal Citation | 62, pp. 78-88 |
Number of Pages | 11 |
Year | 2019 |
Place of Publication | United States |
ISSN | 0271-5317 |
1879-0739 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.nutres.2018.11.002 |
Web Address (URL) | http://www.sciencedirect.com/science/article/pii/S027153171830486X |
Abstract | Chlorogenic acid as a constituent of coffee is consumed regularly in the human diet. Chlorogenic acid intake has been associated with decreased risk of cardiovascular disease and type 2 diabetes. We hypothesized that chlorogenic acid would improve cardiovascular, liver, and metabolic responses in a rat model of metabolic syndrome induced by a high-carbohydrate, high-fat diet. Male Wistar rats (8–9-week-old, 335±2g, n=48) were divided into 4 groups and fed with either corn starch diet (16weeks), corn starch diet with chlorogenic acid in food for the last 8weeks, high-carbohydrate, high-fat diet (16weeks), or high-carbohydrate, high-fat diet with chlorogenic acid (~100mg/kg/day) in food for the last 8weeks. In high-carbohydrate, high-fat diet-fed rats, chlorogenic acid reduced energy intake and food efficiency to reduce visceral fat, especially retroperitoneal fat, and abdominal circumference; reversed the elevated systolic blood pressure and attenuated left ventricular diastolic stiffness with reduced collagen deposition and infiltration of inflammatory cells in the left ventricle. Chlorogenic acid decreased inflammation and fat deposition in the liver along with reduced plasma liver enzyme activities of obese rats but did not change the plasma lipid profile. Chlorogenic acid increased diversity of gut microbiota, which may improve overall metabolism in the body. Thus, chronic dietary chlorogenic acid attenuated diet-induced inflammation as well as cardiovascular, liver, and metabolic changes suggesting that chlorogenic acid has potential for further clinical evaluation. |
Keywords | chlorogenic acid; obesity; metabolic syndrome; cardiovascular disease; coffee; high-carbohydrate; high-fat diet; gut microbiota |
ANZSRC Field of Research 2020 | 321004. Nutritional science |
321401. Basic pharmacology | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Functional Foods Research Group |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q5101/chlorogenic-acid-attenuates-high-carbohydrate-high-fat-diet-induced-cardiovascular-liver-and-metabolic-changes-in-rats
192
total views10
total downloads0
views this month0
downloads this month