Lipid redistribution by alpha linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats
Article
Article Title | Lipid redistribution by alpha linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats |
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ERA Journal ID | 13660 |
Article Category | Article |
Authors | Poudyal, Hemant (Author), Panchal, Sunil K. (Author), Waanders, Jennifer (Author), Ward, Leigh (Author) and Brown, Lindsay (Author) |
Journal Title | Journal of Nutritional Biochemistry |
Journal Citation | 23 (2), pp. 153-162 |
Number of Pages | 10 |
Year | 2012 |
Place of Publication | New York, NY. United States |
ISSN | 0955-2863 |
1873-4847 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jnutbio.2010.11.011 |
Web Address (URL) | http://www.sciencedirect.com/science/article/pii/S0955286311000088 |
Abstract | Chia seeds contain the essential fatty acid, α-linolenic acid (ALA). This study has assessed whether chia seeds attenuated the metabolic, cardiovascular and hepatic signs of a high-carbohydrate, high-fat (H) diet [carbohydrates, 52% (wt/wt); fat, 24% (wt/wt) with 25% (wt/vol) fructose in drinking water] in rats. Diets of the treatment groups were supplemented with 5% chia seeds after 8 weeks on H diet for a further 8 weeks. Compared with the H rats, chia seed-supplemented rats had improved insulin sensitivity and glucose tolerance, reduced visceral adiposity, decreased hepatic steatosis and reduced cardiac and hepatic inflammation and fibrosis without changes in plasma lipids or blood pressure. Chia seeds induced lipid redistribution with lipid trafficking away from the visceral fat and liver |
Keywords | chia seed; α-linolenic acid; metabolic syndrome; high-carbohydrate diet; high-fat diet |
ANZSRC Field of Research 2020 | 320507. Metabolic medicine |
310912. Comparative physiology | |
321004. Nutritional science | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Department of Biological and Physical Sciences |
University of Queensland | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q179y/lipid-redistribution-by-alpha-linolenic-acid-rich-chia-seed-inhibits-stearoyl-coa-desaturase-1-and-induces-cardiac-and-hepatic-protection-in-diet-induced-obese-rats
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