Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats
Article
Article Title | Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats |
---|---|
ERA Journal ID | 200963 |
Article Category | Article |
Authors | Iyer, Abishek (Author), Kauter, Kathleen (Author), Alam, Md. Ashraful (Author), Hwang, Sung Hee (Author), Morisseau, Christophe (Author), Hammock, Bruce D. (Author) and Brown, Lindsay (Author) |
Journal Title | Experimental Diabetes Research |
Journal of Diabetes Research | |
Journal Citation | 2012, pp. 1-11 |
Number of Pages | 11 |
Year | 2012 |
Place of Publication | New York, United States |
ISSN | 1687-5214 |
1687-5303 | |
2314-6745 | |
2314-6753 | |
Digital Object Identifier (DOI) | https://doi.org/10.1155/2012/758614 |
Web Address (URL) | http://www.hindawi.com/journals/edr/2012/758614/ |
Abstract | The signs of metabolic syndrome following chronic excessive macronutrient intake include body weight gain, excess visceral adipose deposition, hyperglycaemia, glucose and insulin intolerances, hypertension, dyslipidaemia, endothelial damage, cardiovascular hypertrophy, inflammation, ventricular contractile dysfunction, fibrosis, and fatty liver disease. Recent studies show increased activity of soluble epoxide hydrolase (sEH) during obesity and metabolic dysfunction. We have tested whether sEH inhibition has therapeutic potential in a rat model of diet-induced metabolic syndrome. In these high-carbohydrate, high-fat-fed rats, chronic oral treatment with trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid (t-AUCB), a potent sEH inhibitor, alleviated the signs of metabolic syndrome in vivo including glucose, insulin, and lipid abnormalities, changes in pancreatic structure, increased systolic blood pressure, cardiovascular structural and functional abnormalities, and structural and functional changes in the liver. The present study describes the pharmacological responses to this selective sEH inhibitor in rats with the signs of diet-induced metabolic syndrome. |
Keywords | metabolic syndrome; hypertension; obesity |
ANZSRC Field of Research 2020 | 320507. Metabolic medicine |
310999. Zoology not elsewhere classified | |
321405. Pharmaceutical sciences | |
Public Notes | Copyright © 2012 Abishek Iyer et al. This is an open access article distributed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Byline Affiliations | University of Queensland |
Department of Biological and Physical Sciences | |
University of California, United States | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q0yx1/pharmacological-inhibition-of-soluble-epoxide-hydrolase-ameliorates-diet-induced-metabolic-syndrome-in-rats
Download files
Published Version
Iyer_Kauter_Alam_Hwang_Morisseau_Hammock_Brown_EDR_2012_PV.pdf | ||
License: CC BY 4.0 | ||
File access level: Anyone |
1981
total views233
total downloads8
views this month3
downloads this month