Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies

Article

Edwards, L. J., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2005. "Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies." American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 288 (1), pp. R39-R45. https://doi.org/10.1152/ajpregu.00127.2004
Article Title

Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies

ERA Journal ID3151
Article CategoryArticle
AuthorsEdwards, L. J. (Author), McFarlane, J. R. (Author), Kauter, K. G. (Author) and McMillen, I. C. (Author)
Journal TitleAmerican Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Journal Citation288 (1), pp. R39-R45
Number of Pages7
Year2005
Place of PublicationBethesda, MD, United States
ISSN0363-6119
1522-1490
Digital Object Identifier (DOI)https://doi.org/10.1152/ajpregu.00127.2004
Abstract

It has been proposed that maternal nutrient restriction may alter the functional development of the adipocyte and the synthesis and secretion of the adipocyte-derived hormone, leptin, before birth. We have investigated the effects of restricted periconceptional undernutrition and/or restricted gestational nutrition on fetal plasma leptin concentrations and fetal adiposity in late gestation. There was no effect of either restricted periconceptional or gestational nutrition on maternal or fetal plasma leptin concentrations in singleton or twin pregnancies during late gestation. In ewes carrying twins, but not singletons, maternal plasma leptin concentrations in late gestation were directly related to the change in ewe weight that occurred during the 60 days before mating [maternal leptin = 0.9 (change in ewe weight) + 7.8; r = 0.6, P < 0.05]. In twin, but not singleton, pregnancies, there was also a significant relationship between maternal and fetal leptin concentrations (maternal leptin = 0.5 fetal leptin + 4.2, r = 0.63, P < 0.005). The relative mass of perirenal fat was also significantly increased in twin fetal sheep in the control-restricted group (6.0 ± 0.5) compared with the other nutritional groups (control-control: 4.1 ± 0.4; restricted-restricted: 4.4 ± 0.4; restricted-control: 4.3 ± 0.3). In conclusion, the impact of maternal undernutrition on maternal plasma leptin concentrations during late gestation is dependent on fetal number. Furthermore, we have found that there is an increased fetal adiposity in the twins of ewes that experienced restricted nutrition throughout gestation, and this may be important in the programming of postnatal adiposity.

Keywordsadipose tissue; animal experiment; article; controlled study; female; fetus; fetus development; hormone release; hormone synthesis; malnutrition; maternal nutrition; nonhuman; obesity; pregnancy; priority journal; sheep; third trimester pregnancy; twin pregnancy
ANZSRC Field of Research 2020310999. Zoology not elsewhere classified
321004. Nutritional science
320899. Medical physiology not elsewhere classified
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Byline AffiliationsUniversity of Adelaide
University of New England
University of South Australia
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