Echinacea induced hsp70 alterations in leukocytes
Poster
Paper/Presentation Title | Echinacea induced hsp70 alterations in leukocytes |
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Presentation Type | Poster |
Authors | Agnew, L. (Author), Matthias, A. (Author), Shipp, C. (Author), Kauter, K. (Author), Bone, K. (Author), Watson, K. (Author) and Lehmann, R. (Author) |
Editors | Melzig, Matthias F. and Kolodziej, Herbert |
Journal or Proceedings Title | Planta Medica |
Planta Medica: natural products and medicinal plant research | |
Journal Citation | 76 (12), pp. 1354-1354 |
Number of Pages | 1 |
Year | 2010 |
Place of Publication | Stuttgart, Germany |
ISSN | 0032-0943 |
1439-0221 | |
Digital Object Identifier (DOI) | https://doi.org/10.1055/s-0030-1264927 |
Web Address (URL) of Paper | https://www.thieme-connect.de/ejournals/abstract/plantamedica/doi/10.1055/s-0030-1264927 |
Conference/Event | 7th Tannin Conference/58th International Congress and Annual Meeting of the Society for Medicinal Plant Product Research |
Event Details | 7th Tannin Conference/58th International Congress and Annual Meeting of the Society for Medicinal Plant Product Research Event Date 29 Aug 2010 to end of 02 Sep 2010 Event Location Berlin, Germany |
Abstract | Heat shock proteins (hsp) are expressed constitutively as well as induced in response to mild stress. These stress factors include inflammation, viral and bacterial infection, oxidative stress and cytotoxins. Altered hsp expression has been found in a number of disease states. Echinacea is used as a prophylactic to boost the immune system and has been previously shown to enhance hsp70 expression in leucocytes after mild heat shock. In this study, the effects of echinacea supplementation on hsp70 expression in the different leucocyte subpopulations has been examined. Twenty four healthy volunteers aged between 20 and 66 years with a body mass index ranging from 20.2 to 30.7 participated in the study. They consumed 2 echinacea tablets (4.42mg total alkylamides per tablet) twice a day for 14 days. Blood samples were taken on days 1 and 15 and hsp70 expression was determined by flow cytometry in whole blood with and without in vitro heat shock. Significant differences were observed in the percentage of several white cell subsets that expressed hsp70. CD4 and CD8 lymphocytes expressed significantly more hsp70 in both males and females after supplementation but in natural killer cells and B lymphocytes, expression of hsp70 were only significantly increased in the male participant cohort. These results indicate that Echinacea may play a role in activating the immune system when the body encounters a challenge such as a virus. |
Keywords | echinacea; leukocytes; medical stress; inflammation; viral infections; bacterial infections; cytotoxins |
ANZSRC Field of Research 2020 | 420899. Traditional, complementary and integrative medicine not elsewhere classified |
429999. Other health sciences not elsewhere classified | |
320208. Endocrinology | |
Public Notes | Copyright. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. This applies in particular to |
Byline Affiliations | University of New England |
Integria Healthcare, Australia | |
University of New South Wales | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q08zq/echinacea-induced-hsp70-alterations-in-leukocytes
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