Leptin alters the structural and functional characteristics of adipose tissue before birth
Article
Article Title | Leptin alters the structural and functional characteristics of adipose tissue before birth |
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ERA Journal ID | 2078 |
Article Category | Article |
Authors | Yuen, B. S. J. (Author), Owens, P. C. (Author), Muhlhausler, B. S. (Author), Roberts, C. T. (Author), Symonds, M. E. (Author), Keisler, D. H. (Author), McFarlane, J. R. (Author), Kauter, K. G. (Author), Evens, Y. (Author) and McMillen, I. C. (Author) |
Journal Title | The FASEB Journal |
Journal Citation | 17 (9), pp. 1102-1104 |
Number of Pages | 3 |
Year | 2003 |
Place of Publication | Bethesda, MD. United States |
ISSN | 0892-6638 |
1530-6860 | |
Digital Object Identifier (DOI) | https://doi.org/10.1096/fj.02-0756fje |
Web Address (URL) | http://www.fasebj.org/cgi/reprint/02-0756fjev1?maxtoshow=&hits=10&RESULTFORMAT=&author1=Yuen&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT |
Abstract | This study aimed to determine for the first time whether leptin can act to alter the structural and functional characteristics of adipose tissue before birth. Leptin (0.48 mg/kg/day) or saline was infused intravenously into fetal sheep for 4 days from either 136 or 137 days of gestation (term=147±3 days). Circulating leptin concentrations were increased approximately four- to fivefold by leptin infusion. Leptin infusion resulted in a significant increase in the proportion of smaller lipid locules present within fetal perirenal adipose tissue (PAT), and this was associated with a significant increase in the proportion of multilocular tissue and a significant decrease in the proportion and relative mass of unilocular tissue in fetal PAT. The relative abundance of leptin mRNA in fetal PAT was significantly lower in the leptin-infused group, and there was a positive correlation between the relative abundance of leptin mRNA and the proportion of unilocular adipose tissue in fetal PAT. The amount of uncoupling protein 1 tended to be higher (P=0.06) in leptin-infused compared with saline-infused fetuses. This is the first demonstration that leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, and potential thermogenic functions of fat before birth. |
Keywords | fetus; lipid; UCP1; leptin |
ANZSRC Field of Research 2020 | 310999. Zoology not elsewhere classified |
300303. Animal nutrition | |
300305. Animal reproduction and breeding | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of Adelaide |
University Hospital Nottingham, United Kingdom | |
University of Missouri, United States | |
University of New England |
https://research.usq.edu.au/item/9zw74/leptin-alters-the-structural-and-functional-characteristics-of-adipose-tissue-before-birth
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