Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation

Article

Muhlhausler, B. S., Adam, C. L., Marrocco, E. M., Findlay, P. A., Roberts, C. T., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2005. "Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation." The Journal of Physiology. 565 (1), pp. 185-195. https://doi.org/10.1113jphysiol.2004.079079
Article Title

Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation

ERA Journal ID3169
Article CategoryArticle
AuthorsMuhlhausler, B. S. (Author), Adam, C. L. (Author), Marrocco, E. M. (Author), Findlay, P. A. (Author), Roberts, C. T. (Author), McFarlane, J. R. (Author), Kauter, K. G. (Author) and McMillen, I. C. (Author)
Journal TitleThe Journal of Physiology
Journal Citation565 (1), pp. 185-195
Number of Pages11
Year2005
Place of PublicationOxford, United Kingdom
ISSN0022-3751
1469-7793
Digital Object Identifier (DOI)https://doi.org/10.1113jphysiol.2004.079079
Web Address (URL)http://jp.physoc.org/content/565/1/185
Abstract

In the present study, our aim was to determine whether intrafetal glucose infusion increases fetal adiposity, synthesis and secretion of leptin and regulates gene expression of the 'appetite regulatory' neuropeptides neuropeptide Y (NPY), agouti-related peptide (AGRP. pro-opiomelanocortin (POMC)and cocaine and amphetamine-regulated transcript (CART) and receptors (leptin receptor (OB-Rb) and melancortin 3 receptor (MC3R))within the fetal hypothalamus. These findings demonstrate that increased circulating glucose and insulin regulate gene expression of the neuropeptides within the fetal hypothalamus that are part of the neural network regulating energy balance in adult life.

Keywordsneuropeptides; fetal hypothalamus; adipose tissue; appetite regulation; blood glucose; foetal blood
ANZSRC Field of Research 2020310903. Animal developmental and reproductive biology
300303. Animal nutrition
300305. Animal reproduction and breeding
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsUniversity of Adelaide
University of Aberdeen, United Kingdom
University of New England
Permalink -

https://research.usq.edu.au/item/9zw7w/impact-of-glucose-infusion-on-the-structural-and-functional-characteristics-of-adipose-tissue-and-on-hypothalamic-gene-expression-for-appetite-regulatory-neuropeptides-in-the-sheep-fetus-during-late

Log in to edit
  • 1804
    total views
  • 12
    total downloads
  • 2
    views this month
  • 0
    downloads this month

Export as

Related outputs

A low-cost, antimicrobial aloe-alginate hydrogel film containing Australian First Nations remedy ‘lemon myrtle oil’ (Backhousia citriodora) – Potential for incorporation into wound dressings
Seneviratne, Dinuki M., Raphael, Brooke, Whiteside, Eliza J., Windus, Louisa C.E., Kauter, Kate, Dearnaley, John D.W., Annamalai, Pratheep K., Ward, Raelene, Song, Pingan and Burey, Paulomi (Polly). 2024. " A low-cost, antimicrobial aloe-alginate hydrogel film containing Australian First Nations remedy ‘lemon myrtle oil’ (Backhousia citriodora) – Potential for incorporation into wound dressings." Heliyon. 10 (18). https://doi.org/10.1016/j.heliyon.2024.e37516
Perspectives on improving wound care for Aboriginal health workers in rural and remote communities in Queensland, Australia
King, Helena, Whiteside, Eliza, Ward, Raelene, Kauter, Kate, Byrne, Martin, Horner, Vicki, Nutter, Helen and Lea, Jackie. 2024. "Perspectives on improving wound care for Aboriginal health workers in rural and remote communities in Queensland, Australia." BMC Health Services Research. 24. https://doi.org/10.1186/s12913-024-11490-2
Fundamentals of Anatomy and Physiology
Chruscik, Anna, Kauter, Kate, Windus, Louisa, Whiteside, Eliza and Dooley, Leanne. 2021. Fundamentals of Anatomy and Physiology . Australia. University of Southern Queensland.
The impact of an anatomy and physiology open textbook on student satisfaction and engagement in a regional Australian university
Chruscik, Anna, Kauter, Kate, Whiteside, Anna and Windus, Louisa. 2022. "The impact of an anatomy and physiology open textbook on student satisfaction and engagement in a regional Australian university." 39th International Conference on Innovation, Practice and Research in the Use of Educational Technologies in Tertiary Education (ASCILITE 2022). Sydney, Australia 04 - 07 Dec 2022 Australia. Australasian Society for Computers in Learning in Tertiary Education (ASCILITE). https://doi.org/10.14742/APUBS.2022.183
How to do science: A guide to researching human physiology
Lexis, Louise, Julien, Brianna, Bliss, Edward, Derrington, Kate, Dooley, Leanne, Kauter, Kate, McGregor, Rowena, Myer, Sarah, Salmeron, Raquel, Suraweera, Samanthi, Whiteside, Eliza and Windus, Louisa. 2022. How to do science: A guide to researching human physiology. Australia. University of Southern Queensland.
Effects of professional compromise on higher education employees
Fein, Erich C., Sadykova, Natalia, Collins, Pauline, Beccaria, Lisa, Goh, Steven and Kauter, Kate. 2021. "Effects of professional compromise on higher education employees." International Journal of Innovative Science and Research Technology. 6 (3), pp. 1047-1055.
Academic achievement and student satisfaction: moving anatomy and physiology teaching online
Chruscik, Anna, Windus, Louisa, Wang, Jianxiong, Kauter, Kate and Whiteside, Eliza. 2020. "Academic achievement and student satisfaction: moving anatomy and physiology teaching online." 2020 Australian Conference on Science and Mathematics Education (formerly UniServe Science Conference). Online 30 Sep - 02 Oct 2020 Australia.
No effect of leptin immunisation on body weight of growing lambs
Kauter, K. G., Schelbach, C., O'Shea, T. and McFarlane, J. R.. 2003. "No effect of leptin immunisation on body weight of growing lambs." 46th Annual Scientific Meeting of the Endocrine Society of Australia. Melbourne, Australia 2003
Dietary restriction has a differential effect on plasma leptin concentrations in fat and lean sheep
Kauter, K., Ball, A., Thompson, J. and McFarlane, James R.. 2002. "Dietary restriction has a differential effect on plasma leptin concentrations in fat and lean sheep." Endocrine Society's 82nd Annual Meeting (2002). San Francisco, United States 19 - 21 Jun 2002
Plasma leptin concentrations correlate positively with the lipid storage capacity of unilocular adipose cells in the sheep fetus during late gestation
Muhlhausler, B. S., Roberts, C. T., Kauter, K. G., McFarlane, J. R., Stagg, P. L., McMillen, I. C. and Pearse, J. K.. 2002. "Plasma leptin concentrations correlate positively with the lipid storage capacity of unilocular adipose cells in the sheep fetus during late gestation." 2002 Australian Health and Medical Research Congress (AHMRC 2002). Melbourne, Australia 25 - 27 Nov 2002
Leptin-a potential signal of relative uniocular fat mass and lipid content of unilocular adipose cells in the late gestation fetal sheep
Muhlhausler, B. S., Roberts, C. T., Kauter, K. G., McFarlane, J. R., Stagg, P. L., Pearse, J. K. and McMillen, I. C.. 2002. "Leptin-a potential signal of relative uniocular fat mass and lipid content of unilocular adipose cells in the late gestation fetal sheep." 2002 Australian Health and Medical Research Congress (AHMRC 2002). Melbourne, Australia 25 - 27 Nov 2002
Leptin is a signal of adiposity in fetuses of pregnant ewes fed at or above maintenance energy requirements
Muhlhausler, B. S., Roberts, C. T., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2002. "Leptin is a signal of adiposity in fetuses of pregnant ewes fed at or above maintenance energy requirements." British Society of Animal Science (2002). United Kingdom 08 - 10 Apr 2002
The effects of lithium on reticulo-rumen motility of sheep and goats
Kauter, K. G. and Godwin, I. R.. 1995. "The effects of lithium on reticulo-rumen motility of sheep and goats." Recent Advances in Animal Nutrition in Australia 1995. Armidale, Australia Jul 1995
Effects of resveratrol supplementation on bone growth in young rats and microarchitecture and remodeling in ageing rats
Lee, Alice M. C., Shandala, Tetyana, Nguyen, Long, Muhlhausler, Beverly S., Chen, Ke Ming, Howe, Peter R. and Xian, Cory J.. 2014. "Effects of resveratrol supplementation on bone growth in young rats and microarchitecture and remodeling in ageing rats." Nutrients. 6 (12), pp. 5871-5887. https://doi.org/10.3390/nu6125871
Leptin clearance rates during the estrous cycle in sheep
Kauter, K. G., Hunt, M., Kokta, T., O'Shea, H. R. and McFarlane, J. R.. 2005. "Leptin clearance rates during the estrous cycle in sheep." ENDO 2005: 87th Annual Meeting of the Endocrine Society. San Diego, United States 04 - 07 Jun 2005
Effect of intravenous infusion of leptin on the pituitary-adrenal axis in the sheep fetus
Yuen, B. S. J., Owens, P. C., McFarlane, J. R., Edwards, L. J., Symonds, M. E., Kauter, K. G. and McMillen, I. C.. 2001. "Effect of intravenous infusion of leptin on the pituitary-adrenal axis in the sheep fetus." 44th Annual Scientific Meeting of the Endocrine Society of Australia 2001. Gold Coast, Australia 09 - 12 Sep 2001
Ultradian rhythms in adult entire and castrate male and female merino sheep
Kauter, K. G. and McFarlane, J. R.. 2001. "Ultradian rhythms in adult entire and castrate male and female merino sheep." 44th Annual Scientific Meeting of the Endocrine Society of Australia 2001. Gold Coast, Australia 09 - 12 Sep 2001
Plasma leptin concentrations in sheep following dietary restriction
McFarlane, J. R., Kauter, K. G., Ball, A. and Thompson, J.. 2001. "Plasma leptin concentrations in sheep following dietary restriction." 44th Annual Scientific Meeting of the Endocrine Society of Australia 2001. Gold Coast, Australia 09 - 12 Sep 2001
Leptin in maternal and fetal plasma fluids during pregnancy in the sheep
Kauter, Kate G., O'Shea, T. and McFarlane, J. R.. 2000. "Leptin in maternal and fetal plasma fluids during pregnancy in the sheep." 11th International Congress of Endocrinology, 2000. Sydney, Australia 29 Oct - 02 Nov 2000
Gestational leptin profile of Merino sheep
Kauter, Kate G., O'Shea, T. and McFarlane, J. R.. 2000. "Gestational leptin profile of Merino sheep." Fertility 2000: Joint Meeting of the Society for the Study of Fertility, British Fertility Society and British Andrology Society. Edinburgh, United Kingdom 30 Jul - 02 Aug 2000
Sexual dimorphism and pregnancy profiles of leptin in Merino sheep
Godwin, I., Kauter, Kate G., O'Shea, T. and McFarlane, J. R.. 2000. "Sexual dimorphism and pregnancy profiles of leptin in Merino sheep." ICAR Satellite Symposium on Reproduction in Small Ruminants 2000. Sandnes, Norway 30 Jun 2000
Cortisol levels in hair reflect behavioural reactivity of dogs to acoustic stimuli
Siniscalchi, M., McFarlane, J. R., Kauter, K. G., Quaranta, A. and Rogers, L. J.. 2013. "Cortisol levels in hair reflect behavioural reactivity of dogs to acoustic stimuli." Research in Veterinary Science. 94 (1), pp. 49-54. https://doi.org/10.1016/j.rvsc.2012.02.017
Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats
Diwan, Vishal, Small, David, Kauter, Kate, Gobe, Glenda C. and Brown, Lindsay. 2014. "Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats." American Journal of Physiology: Renal Physiology. 307 (11), pp. F1169-F1178. https://doi.org/10.1152/ajprenal.00676.2013
Concentration of cortisol in human hair under rest and pain conditions
Sharpley, Christopher F., Kauter, Kathleen G. and McFarlane, James R.. 2010. "Concentration of cortisol in human hair under rest and pain conditions." Solomon, Sam and Dampney, Roger (ed.) 30th Annual Meeting of Australian Neuroscience/Australian Physiological Society. Sydney, Australia 31 Jan - 03 Feb 2010 Melbourne, Australia.
The role of leptin in reproduction and fertility
McFarlane, Jim, Kauter, Kate and Panwar, Shalini. 2008. "The role of leptin in reproduction and fertility." Chopin, John (ed.) Australian College of Veterinary Scientists 2008 Annual Conference. Surfers Paradise, Australia 03 - 06 Jul 2008
The effects of intravenous glucose and fructose on insulin levels in sheep
Cookson, S. M., Godwin, I. R., McFarlane, J. R., Kauter, K. G., Ciller, U., Ciller, I. M. and Metcalfe, K. E.. 2008. "The effects of intravenous glucose and fructose on insulin levels in sheep." Nutrition Society of Australia Conference (2008). Glenelg, Australia 30 Nov - 03 Dec 2008
Modulation of leukocyte hsp70 expression by gender, menstrual cycle phase and oral contraceptives
Agnew, L. L., Colditz, I. G., Rae, K., Kauter, K. G., McFarlane, J. R. and Watson, K.. 2009. "Modulation of leukocyte hsp70 expression by gender, menstrual cycle phase and oral contraceptives." Sato, Noriyuki (ed.) 4th International Congress on Stress Responses in Biology and Medicine (CSSI 2009): Hallmarks and New Horizons in Biomedical Stress Responses. Sapporo, Japan 06 - 09 Oct 2009 Storrs, CT. United States.
Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA
Kauter, K., Ball, M., Kearney, P., Tellam, R. and McFarlane, J. R.. 2000. "Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA." Journal of Endocrinology. 166 (1), pp. 127-135.
Chronic l-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats
Alam, Md. Ashraful, Kauter, Kathleen, Withers, Kerry, Sernia, Conrad and Brown, Lindsay. 2013. "Chronic l-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats." Food and Function. 4 (1), pp. 83-91. https://doi.org/10.1039/c2fo30096f
Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats
Alam, Md. Ashraful, Kauter, Kathleen and Brown, Lindsay. 2013. "Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats." Nutrients. 5 (3), pp. 637-650. https://doi.org/10.3390/nu5030637
Caffeine attenuates metabolic syndrome in diet-induced obese rats
Panchal, Sunil K., Wong, Weng-Yew, Kauter, Kate, Ward, Leigh C. and Brown, Lindsay. 2012. "Caffeine attenuates metabolic syndrome in diet-induced obese rats." Nutrition. 28 (10), pp. 1055-1062. https://doi.org/10.1016/j.nut.2012.02.013
Gender differences in metabolic syndrome - a key research issue
Iyer, Abishek, Kauter, Kathleen and Brown, Lindsay. 2011. "Gender differences in metabolic syndrome - a key research issue." Endocrine, Metabolic and Immune Disorders: Drug Targets. 11 (3), pp. 182-188.
Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats
Iyer, Abishek, Kauter, Kathleen, Alam, Md. Ashraful, Hwang, Sung Hee, Morisseau, Christophe, Hammock, Bruce D. and Brown, Lindsay. 2012. "Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats." Experimental Diabetes Research. 2012, pp. 1-11. https://doi.org/10.1155/2012/758614
Echinacea induced hsp70 alterations in leukocytes
Agnew, L., Matthias, A., Shipp, C., Kauter, K., Bone, K., Watson, K. and Lehmann, R.. 2010. "Echinacea induced hsp70 alterations in leukocytes." Melzig, Matthias F. and Kolodziej, Herbert (ed.) 7th Tannin Conference/58th International Congress and Annual Meeting of the Society for Medicinal Plant Product Research. Berlin, Germany 29 Aug - 02 Sep 2010 Stuttgart, Germany. https://doi.org/10.1055/s-0030-1264927
High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats
Panchal, Sunil K., Poudyal, Hemant, Iyer, Abishek, Nazer, Reeza, Alam, Md. Ashraful, Diwan, Vishal, Kauter, Kathleen, Sernia, Conrad, Campbell, Fiona, Ward, Leigh, Gobe, Glenda, Fenning, Andrew and Brown, Lindsay. 2011. "High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats." Journal of Cardiovascular Pharmacology. 57 (5), pp. 611-624. https://doi.org/10.1097/FJC.0b013e3181feb90a
Leptin is a signal of fetal adiposity in pregnant ewes fed at or above maintenance energy requirements
Muhlhausler, B. S., Roberts, C. T., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2002. "Leptin is a signal of fetal adiposity in pregnant ewes fed at or above maintenance energy requirements." 49th Annual Meeting Society for Gynecologic Investigation. Los Angeles, United States 20 - 23 Mar 2002 United States.
Circulating leptin concentrations are positively related to leptin messenger RNA expression in the adipose tissue of fetal sheep in the pregnant ewe fed at or below maintenance energy requirements during late gestation
Yuen, B. S. J., Owens, P. C., McFarlane, J. R., Symonds, M. E., Edwards, L. J., Kauter, K. G. and McMillen, I. C.. 2002. "Circulating leptin concentrations are positively related to leptin messenger RNA expression in the adipose tissue of fetal sheep in the pregnant ewe fed at or below maintenance energy requirements during late gestation." Biology of Reproduction. 67 (3), pp. 911-916. https://doi.org/10.1095/biolreprod.101.002931
Unusual susceptibility of sheep selected for resistance to internal parasites
Gray, G. D., Gill, H. S., Kauter, K. G., Burgess, S. K. and Douglas-Hill, A.. 1994. "Unusual susceptibility of sheep selected for resistance to internal parasites." 5th World Congress on Genetics Applied to Livestock Production. Guelph, Canada 15 Sep 1994 Canada.
Echinacea induced hsp70 alterations in leukocytes
Agnew, L. L., Matthias, A., Shipp, C., Kauter, K. G., Bone, K. M., Watson, K. and Lehmann, R. P.. 2010. "Echinacea induced hsp70 alterations in leukocytes." AHMR 2010: 5th Australian Health and Medical Research Congress. Melbourne, Australia 14 - 18 Nov 2010 Australia.
Hair cortisol concentration differs across site and person: localisation and consistency of responses to a brief pain stressor
Sharpley, C. F., Kauter, K. G. and McFarlane, J. R.. 2010. "Hair cortisol concentration differs across site and person: localisation and consistency of responses to a brief pain stressor." Physiological Research. 59 (6), pp. 979-983.
Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator activated receptor y; (PPARy;)mRNA expression in visceral fat in the lamb
Duffield, Jaime A., Vuocolo, Tony, Tellam, Ross, McFarlane, Jim R., Kauter, Kate G., Muhlhausler, B. S. and McMillen, I. Caroline. 2009. "Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator activated receptor y; (PPARy;)mRNA expression in visceral fat in the lamb." Pediatric Research. 66 (1), pp. 59-65. https://doi.org/10.1203/PDR.0b013e3181a7c121
An initial exploration of in vivo hair cortisol responses to a brief pain stressor: latency, localization and independence effects
Sharpley, C. F., Kauter, K. G. and McFarlane, J. R.. 2009. "An initial exploration of in vivo hair cortisol responses to a brief pain stressor: latency, localization and independence effects." Physiological Research. 58 (5), pp. 757-761.
An investigation of hair cortisol concentration across body sites and within hair shaft
Sharpley, Christopher F., Kauter, Kathleen G. and McFarlane, James R.. 2010. "An investigation of hair cortisol concentration across body sites and within hair shaft." Clinical Medicine Insights: Endocrinology and Diabetes. 3, pp. 17-23. https://doi.org/10.4137/CMED.S4465
Diurnal variation in peripheral (hair) vs central (saliva) HPA axis cortisol concentrations
Sharpley, Christopher F., Kauter, Kathleen G. and McFarlane, James R.. 2010. "Diurnal variation in peripheral (hair) vs central (saliva) HPA axis cortisol concentrations." Clinical Medicine Insights: Endocrinology and Diabetes. 3, pp. 9-16. https://doi.org/10.4137/CMED.S4350
Fetal leptin is a signal of fat mass independent of maternal nutrition in ewes fed at or above maintenance energy requirements
Muhlhausler, B. S., Roberts, C. T., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2002. "Fetal leptin is a signal of fat mass independent of maternal nutrition in ewes fed at or above maintenance energy requirements." Biology of Reproduction. 67 (2), pp. 493-499. https://doi.org/10.1095/biolreprod67.2.493
Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies
Edwards, L. J., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2005. "Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies." American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 288 (1), pp. R39-R45. https://doi.org/10.1152/ajpregu.00127.2004
Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy
Muhlhausler, B. S., Roberts, C. T., Yuen, B. S. J., Marrocco, E., Budge, H., Symonds, M. E., McFarlane, J. R., Kauter, K. G., Stagg, P., Pearse, J. K. and McMillen, I. C.. 2003. "Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy." Endocrinology. 144 (11), pp. 4947-4954. https://doi.org/10.1210/en.2003-0555
Leptin alters the structural and functional characteristics of adipose tissue before birth
Yuen, B. S. J., Owens, P. C., Muhlhausler, B. S., Roberts, C. T., Symonds, M. E., Keisler, D. H., McFarlane, J. R., Kauter, K. G., Evens, Y. and McMillen, I. C.. 2003. "Leptin alters the structural and functional characteristics of adipose tissue before birth." The FASEB Journal. 17 (9), pp. 1102-1104. https://doi.org/10.1096/fj.02-0756fje
Effects of leptin on fetal plasma adrenocorticotropic hormone and cortisol concentrations and the timing of parturition in the sheep
Yuen, B. S. J., Owens, P. C., Symonds, M. E., Keisler, D. H., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2004. "Effects of leptin on fetal plasma adrenocorticotropic hormone and cortisol concentrations and the timing of parturition in the sheep." Biology of Reproduction. 70 (6), pp. 1650-1657. https://doi.org/10.1095/biolreprod.103.025254