Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation

Article

Muhlhausler, B. S., Adam, C. L., Marrocco, E. M., Findlay, P. A., Roberts, C. T., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2005. "Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation." The Journal of Physiology. 565 (1), pp. 185-195. https://doi.org/10.1113jphysiol.2004.079079
Article Title

Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation

ERA Journal ID3169
Article CategoryArticle
AuthorsMuhlhausler, B. S. (Author), Adam, C. L. (Author), Marrocco, E. M. (Author), Findlay, P. A. (Author), Roberts, C. T. (Author), McFarlane, J. R. (Author), Kauter, K. G. (Author) and McMillen, I. C. (Author)
Journal TitleThe Journal of Physiology
Journal Citation565 (1), pp. 185-195
Number of Pages11
Year2005
Place of PublicationOxford, United Kingdom
ISSN0022-3751
1469-7793
Digital Object Identifier (DOI)https://doi.org/10.1113jphysiol.2004.079079
Web Address (URL)http://jp.physoc.org/content/565/1/185
Abstract

In the present study, our aim was to determine whether intrafetal glucose infusion increases fetal adiposity, synthesis and secretion of leptin and regulates gene expression of the 'appetite regulatory' neuropeptides neuropeptide Y (NPY), agouti-related peptide (AGRP. pro-opiomelanocortin (POMC)and cocaine and amphetamine-regulated transcript (CART) and receptors (leptin receptor (OB-Rb) and melancortin 3 receptor (MC3R))within the fetal hypothalamus. These findings demonstrate that increased circulating glucose and insulin regulate gene expression of the neuropeptides within the fetal hypothalamus that are part of the neural network regulating energy balance in adult life.

Keywordsneuropeptides; fetal hypothalamus; adipose tissue; appetite regulation; blood glucose; foetal blood
ANZSRC Field of Research 2020310903. Animal developmental and reproductive biology
300303. Animal nutrition
300305. Animal reproduction and breeding
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Byline AffiliationsUniversity of Adelaide
University of Aberdeen, United Kingdom
University of New England
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https://research.usq.edu.au/item/9zw7w/impact-of-glucose-infusion-on-the-structural-and-functional-characteristics-of-adipose-tissue-and-on-hypothalamic-gene-expression-for-appetite-regulatory-neuropeptides-in-the-sheep-fetus-during-late

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