The effects of intravenous glucose and fructose on insulin levels in sheep

Poster

Cookson, S. M., Godwin, I. R., McFarlane, J. R., Kauter, K. G., Ciller, U., Ciller, I. M. and Metcalfe, K. E.. 2008. "The effects of intravenous glucose and fructose on insulin levels in sheep." Nutrition Society of Australia Conference (2008). Glenelg, Australia 30 Nov - 03 Dec 2008
Paper/Presentation Title

The effects of intravenous glucose and fructose on insulin levels in sheep

Presentation TypePoster
AuthorsCookson, S. M. (Author), Godwin, I. R. (Author), McFarlane, J. R. (Author), Kauter, K. G. (Author), Ciller, U. (Author), Ciller, I. M. (Author) and Metcalfe, K. E. (Author)
Journal or Proceedings TitleProceedings of the Nutrition Society of Australia
Journal Citation32 (3 (Supplement))
Article NumberS70
Number of Pages1
Year2008
Web Address (URL) of Paperhttp://apjcn.nhri.org.tw/server/APJCN/ProcNutSoc/2000+/2008/Vol%2017%20_S3%2080.pdf
Conference/EventNutrition Society of Australia Conference (2008)
Event Details
Nutrition Society of Australia Conference (2008)
Event Date
30 Nov 2008 to end of 03 Dec 2008
Event Location
Glenelg, Australia
Abstract

A high fructose diet is known to cause insulin resistance in a wide range of mammals. An acute oral loading of fructose has no effect on the insulin level of normal or diabetic animals. No studies have investigated the effects of intravenous fructose loading in sheep, a species which generally derives all blood glucose from gluconeogenesis.
Objective – To compare the effects of a bolus loading of intravenous fructose and glucose on blood glucose and insulin levels in sheep.
Design – Ten crossbred wethers were fed lucerne chaff ad libitum. They were given either 0.24 g/kg of glucose or fructose intravenously in a single bolus dose. Plasma glucose, fructose and insulin were measured in serial blood samples for the following six hours.
Outcomes – As expected glucose infusion resulted in a substantial rise in blood glucose and a modest increase in
insulin level. The fructose infusion led to very a modest rise in blood fructose and large increase in plasma insulin level with a resultant fall in blood glucose level.
Conclusion – Sheep respond differently to other mammals to fructose loading. Intravenous fructose stimulates insulin release in sheep. This response is different to most other mammals which show insulin refractoriness to
fructose loading.

Keywordssheep; fructose; insulin resistance
ANZSRC Field of Research 2020319999. Other biological sciences not elsewhere classified
429999. Other health sciences not elsewhere classified
Byline AffiliationsUniversity of New England
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