Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats

Article

Diwan, Vishal, Small, David, Kauter, Kate, Gobe, Glenda C. and Brown, Lindsay. 2014. "Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats." American Journal of Physiology: Renal Physiology. 307 (11), pp. F1169-F1178. https://doi.org/10.1152/ajprenal.00676.2013
Article Title

Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats

ERA Journal ID15654
Article CategoryArticle
AuthorsDiwan, Vishal (Author), Small, David (Author), Kauter, Kate (Author), Gobe, Glenda C. (Author) and Brown, Lindsay (Author)
Journal TitleAmerican Journal of Physiology: Renal Physiology
Journal Citation307 (11), pp. F1169-F1178
Number of Pages10
Year2014
Place of PublicationBethesda, MD. United States
ISSN1522-1466
1931-857X
Digital Object Identifier (DOI)https://doi.org/10.1152/ajprenal.00676.2013
Web Address (URL)http://ajprenal.physiology.org/content/ajprenal/307/11/F1169.full.pdf
Abstract

Gender contributes to differences in incidence and progression of chronic kidney disease (CKD) and associated cardiovascular disease. To induce kidney damage in male and female Wistar rats (n = 12/group), a 0.25% adenine diet for 16 wk was used. Kidney function (blood urea nitrogen, plasma creatinine, proteinuria) and structure (glomerular damage, tubulointerstitial atrophy, fibrosis, inflammation); cardiovascular function (blood pressure, ventricular stiffness, vascular responses, echocardiography) and structure (cardiac fibrosis); plasma testosterone and estrogen concentrations; and protein expression for oxidative stress [heme oxygenase-1, inflammation (TNF-α), fibrosis (transforming growth factor-(3), ERK1/2, and estrogen receptor-α (ER-α)] were compared in males and females. Adenine-fed females had less decline in kidney function than adenine-fed males, although kidney atrophy, inflammation, and fibrosis were similar. Plasma estrogen concentrations increased and plasma testosterone concentrations decreased in adenine-fed males, with smaller changes in females. CKD-associated molecular changes in kidneys were more pronounced in males than females except for expression of ER-α in the kidney, which was completely suppressed in adenine-fed males but unchanged in adenine-fed females. Both genders showed increased blood pressure, ventricular stiffness, and cardiac fibrosis with the adenine diet. Cardiovascular changes with adenine were similar in males and females, except males developed concentric, and females eccentric cardiac hypertrophy. In hearts from adenine-fed male and female rats, expression of ER-α and activation of the ERK1/2 pathway were increased, in part explaining changes in cardiac hypertrophy. In summary, adenine-induced kidney damage may be increased in males due to the suppression of ER-α.

Keywordscardiovascular disease; chronic kidney disease; ERK1/2; estrogen receptor-α; inflammation
ANZSRC Field of Research 2020320214. Nephrology and urology
310910. Animal physiology - systems
320101. Cardiology (incl. cardiovascular diseases)
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Byline AffiliationsUniversity of Queensland
School of Health, Nursing and Midwifery
School of Health and Wellbeing
Institution of OriginUniversity of Southern Queensland
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Shafie, Siti Raihanah, Poudyal, Hemant, Panchal, Sunil K. and Brown, Lindsay. 2016. "Linseed as a functional food for the management of obesity." Hegde, Mahabaleshwar V., Zanwar, Anand Arvind and Adekar, Sharad P. (ed.) Omega-3 fatty acids: keys to nutritional health. Switzerland. Springer. pp. 173-187
Selenium, vanadium, and chromium as micronutrients to improve metabolic syndrome
Panchal, Sunil K., Wanyonyi, Stephen and Brown, Lindsay. 2017. "Selenium, vanadium, and chromium as micronutrients to improve metabolic syndrome." Current Hypertension Reports. 19 (3), pp. 10-20. https://doi.org/10.1007/s11906-017-0701-x
Emerging benefits of AT1 receptor antagonists with pleiotropic anti-inflammatory activity
Sernia, Conrad and Brown, Lindsay. 2011. "Emerging benefits of AT1 receptor antagonists with pleiotropic anti-inflammatory activity." American Journal of Hypertension. 24 (7), pp. 739-739. https://doi.org/10.1038/ajh.2011.61
Leptin clearance rates during the estrous cycle in sheep
Kauter, K. G., Hunt, M., Kokta, T., O'Shea, H. R. and McFarlane, J. R.. 2005. "Leptin clearance rates during the estrous cycle in sheep." ENDO 2005: 87th Annual Meeting of the Endocrine Society. San Diego, United States 04 - 07 Jun 2005
Effect of intravenous infusion of leptin on the pituitary-adrenal axis in the sheep fetus
Yuen, B. S. J., Owens, P. C., McFarlane, J. R., Edwards, L. J., Symonds, M. E., Kauter, K. G. and McMillen, I. C.. 2001. "Effect of intravenous infusion of leptin on the pituitary-adrenal axis in the sheep fetus." 44th Annual Scientific Meeting of the Endocrine Society of Australia 2001. Gold Coast, Australia 09 - 12 Sep 2001
Ultradian rhythms in adult entire and castrate male and female merino sheep
Kauter, K. G. and McFarlane, J. R.. 2001. "Ultradian rhythms in adult entire and castrate male and female merino sheep." 44th Annual Scientific Meeting of the Endocrine Society of Australia 2001. Gold Coast, Australia 09 - 12 Sep 2001
Plasma leptin concentrations in sheep following dietary restriction
McFarlane, J. R., Kauter, K. G., Ball, A. and Thompson, J.. 2001. "Plasma leptin concentrations in sheep following dietary restriction." 44th Annual Scientific Meeting of the Endocrine Society of Australia 2001. Gold Coast, Australia 09 - 12 Sep 2001
Leptin in maternal and fetal plasma fluids during pregnancy in the sheep
Kauter, Kate G., O'Shea, T. and McFarlane, J. R.. 2000. "Leptin in maternal and fetal plasma fluids during pregnancy in the sheep." 11th International Congress of Endocrinology, 2000. Sydney, Australia 29 Oct - 02 Nov 2000
Gestational leptin profile of Merino sheep
Kauter, Kate G., O'Shea, T. and McFarlane, J. R.. 2000. "Gestational leptin profile of Merino sheep." Fertility 2000: Joint Meeting of the Society for the Study of Fertility, British Fertility Society and British Andrology Society. Edinburgh, United Kingdom 30 Jul - 02 Aug 2000
Sexual dimorphism and pregnancy profiles of leptin in Merino sheep
Godwin, I., Kauter, Kate G., O'Shea, T. and McFarlane, J. R.. 2000. "Sexual dimorphism and pregnancy profiles of leptin in Merino sheep." ICAR Satellite Symposium on Reproduction in Small Ruminants 2000. Sandnes, Norway 30 Jun 2000
Cortisol levels in hair reflect behavioural reactivity of dogs to acoustic stimuli
Siniscalchi, M., McFarlane, J. R., Kauter, K. G., Quaranta, A. and Rogers, L. J.. 2013. "Cortisol levels in hair reflect behavioural reactivity of dogs to acoustic stimuli." Research in Veterinary Science. 94 (1), pp. 49-54. https://doi.org/10.1016/j.rvsc.2012.02.017
Anti-inflammatory γ- and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats
Wong, Weng-Yew, Ward, Leigh C., Fong, Chee Wai, Yap, Wei Ney and Brown, Lindsay. 2017. "Anti-inflammatory γ- and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats." European Journal of Nutrition. 56 (1), pp. 133-150. https://doi.org/10.1007/s00394-015-1064-1
Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease
Iyer, Abishek, Brown, Lindsay, Whitehead, Jonathan P., Prins, Johannes B. and Fairlie, David P.. 2015. "Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease." The FASEB Journal. 29 (9), pp. 3612-25. https://doi.org/10.1096/fj.15-271155
Modulation of tissue fatty acids by l-carnitine attenuates metabolic syndrome in diet-induced obese rats
Panchal, Sunil K., Poudyal, Hemant, Ward, Leigh C., Waanders, Jennifer and Brown, Lindsay. 2015. "Modulation of tissue fatty acids by l-carnitine attenuates metabolic syndrome in diet-induced obese rats." Food and Function. 6 (8), pp. 2496-2506. https://doi.org/10.1039/C5FO00480B
Cyanidin 3-glucoside improves diet-induced metabolic syndrome in rats
Bhaswant, Maharshi, Fanning, Kent, Netzel, Michael, Mathai, Michael L., Panchal, Sunil K. and Brown, Lindsay. 2015. "Cyanidin 3-glucoside improves diet-induced metabolic syndrome in rats." Pharmacological Research. 102, pp. 208-217. https://doi.org/10.1016/j.phrs.2015.10.006
Green and black cardamom in a diet-induced rat model of metabolic syndrome
Bhaswant, Maharshi, Poudyal, Hemant, Mathai, Michael L., Ward, Leigh C., Mouatt, Peter and Brown, Lindsay. 2015. "Green and black cardamom in a diet-induced rat model of metabolic syndrome." Nutrients. 7 (9), pp. 7691-7707. https://doi.org/10.3390/nu7095360
Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids
Bhaswant, Maharshi, Poudyal, Hemant and Brown, Lindsay. 2015. "Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids." Journal of Nutritional Biochemistry. 26 (6), pp. 571-584. https://doi.org/10.1016/j.jnutbio.2015.02.001
Targets for pharmacological modulation of cardiac fibrosis
Brown, Lindsay, Chan, Vincent and Fenning, Andrew. 2005. "Targets for pharmacological modulation of cardiac fibrosis." Villarreal, Francisco J. (ed.) Interstitial fibrosis in heart failure. Boston, United States. Springer. pp. 275-310
Rat models of chronic heart failure
Chan, Vincent and Brown, Lindsay. 2005. "Rat models of chronic heart failure." Gupta, S. K., Singal, P. K. and Agrawa, S. S. (ed.) Pharmacotherapy of heart failure. New Delhi, India. Anamaya Publishers. pp. 38-55
Mechanism of the anti-hypertensive property of the naturally occurring phenolic, malabaricone C in DOCA-salt rats
Rathee, Jitesh S., Patro, Birija S., Brown, Lindsay and Chattopadhyay, Subrata. 2016. "Mechanism of the anti-hypertensive property of the naturally occurring phenolic, malabaricone C in DOCA-salt rats." Free Radical Research. 50 (1), pp. 111-121. https://doi.org/10.3109/10715762.2015.1112005
Functional foods as potential therapeutic options for metabolic syndrome
Brown, L., Poudyal, H. and Panchal, S. K.. 2015. "Functional foods as potential therapeutic options for metabolic syndrome." Obesity Reviews. 16 (11), pp. 914-941. https://doi.org/10.1111/obr.12313
Should the pharmacological actions of dietary fatty acids in cardio-metabolic disorders be classified based on biological or chemical function?
Poudyal, Hemant and Brown, Lindsay. 2015. "Should the pharmacological actions of dietary fatty acids in cardio-metabolic disorders be classified based on biological or chemical function?" Progress in Lipid Research. 59, pp. 172-200. https://doi.org/10.1016/j.plipres.2015.07.002
Induction of metabolic syndrome by excess fructose consumption
Wong, Weng-Yew and Brown, Lindsay. 2014. "Induction of metabolic syndrome by excess fructose consumption." Turan, Belma and Dhalla, Naranjan S. (ed.) Diabetic cardiomyopathy: biochemical and molecular mechanisms. New York, NY. United States. Springer. pp. 41-63
A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats
Kumar, Senthil Arun, Magnusson, Marie, Ward, Leigh C., Paul, Nicholas A. and Brown, Lindsay. 2015. "A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats." Nutrients. 7 (4), pp. 2771-2787. https://doi.org/10.3390/nu7042771
Prebiotics in obesity
Carnahan, S., Balzer, A., Panchal, S. K. and Brown, L.. 2014. "Prebiotics in obesity." Panminerva Medica. 56 (2), pp. 165-175.
Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury
Gobe, Glenda C., Bennett, Nigel C., West, Malcolm, Colditz, Paul, Brown, Lindsay, Vesey, David A. and Johnson, David W.. 2014. "Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury." American Journal of Physiology: Renal Physiology. 306 (6), pp. F681-F692. https://doi.org/10.1152/ajprenal.00241.2013
Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats
Kumar, Senthil Arun, Magnusson, Marie, Ward, Leigh C., Paul, Nicholas A. and Brown, Lindsay. 2015. "Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats." Marine Drugs. 13 (2), pp. 788-805. https://doi.org/10.3390/md13020788
Nutraceuticals for chronic inflammatory diseases
Brown, Lindsay. 2013. "Nutraceuticals for chronic inflammatory diseases." Journal of the Australian Traditional-Medicine Society. 19 (4), pp. 214-221.
Obesity and metabolic syndrome
Panchal, Sunil K., Bhaswant, Maharshu and Brown, Lindsay. 2014. "Obesity and metabolic syndrome." Vela, Jose M., Maldonado, Rafael and Hamon, Michel (ed.) In vivo models for drug discovery. Weinheim, Germany. John Wiley & Sons. pp. 333-348
Glibenclamide improves kidney and heart structure and function in the adenine-diet model of chronic kidney disease
Diwan, Vishal, Gobe, Glenda and Brown, Lindsay. 2014. "Glibenclamide improves kidney and heart structure and function in the adenine-diet model of chronic kidney disease." Pharmacological Research. 79, pp. 104-110. https://doi.org/10.1016/j.phrs.2013.11.007
Effects of red pitaya juice supplementation on cardiovascular and hepatic changes in high-carbohydrate, high-fat diet-induced metabolic syndrome rats
Ramli, Nurul Shazini, Brown, Lindsay, Ismail, Patimah and Rahmat, Asmah. 2014. "Effects of red pitaya juice supplementation on cardiovascular and hepatic changes in high-carbohydrate, high-fat diet-induced metabolic syndrome rats." BMC Complementary Medicine and Therapies. 14, pp. 189-198. https://doi.org/10.1186/1472-6882-14-189
Concentration of cortisol in human hair under rest and pain conditions
Sharpley, Christopher F., Kauter, Kathleen G. and McFarlane, James R.. 2010. "Concentration of cortisol in human hair under rest and pain conditions." Solomon, Sam and Dampney, Roger (ed.) 30th Annual Meeting of Australian Neuroscience/Australian Physiological Society. Sydney, Australia 31 Jan - 03 Feb 2010 Melbourne, Australia.
The role of leptin in reproduction and fertility
McFarlane, Jim, Kauter, Kate and Panwar, Shalini. 2008. "The role of leptin in reproduction and fertility." Chopin, John (ed.) Australian College of Veterinary Scientists 2008 Annual Conference. Surfers Paradise, Australia 03 - 06 Jul 2008
The effects of intravenous glucose and fructose on insulin levels in sheep
Cookson, S. M., Godwin, I. R., McFarlane, J. R., Kauter, K. G., Ciller, U., Ciller, I. M. and Metcalfe, K. E.. 2008. "The effects of intravenous glucose and fructose on insulin levels in sheep." Nutrition Society of Australia Conference (2008). Glenelg, Australia 30 Nov - 03 Dec 2008
Food as medicine [Introduction]
Panchal, Sunil K., Ward, Leigh C. and Brown, Lindsay. 2013. "Food as medicine [Introduction]." Canadian Journal of Physiology and Pharmacology. 91 (6), pp. 503-503. https://doi.org/10.1139/cjpp-2013-0147
Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism
Lim, Junxian, Iyer, Abishek, Liu, Ligong, Suen, Jacky Y., Lohman, Rink-Jan, Seow, Vernon, Yau, Mei-Kwan, Brown, Lindsay and Fairlie, David P.. 2013. "Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism." The FASEB Journal. 27 (12), pp. 4757-4767. https://doi.org/10.1096/fj.13-232702
Osteoporosis and its association with non-gonadal hormones involved in hypertension, adiposity and hyperglycaemia
Poudyal, Hemant and Brown, Lindsay. 2013. "Osteoporosis and its association with non-gonadal hormones involved in hypertension, adiposity and hyperglycaemia." Current Drug Targets. 14 (14), pp. 1694-1706. https://doi.org/10.2174/1389450119999990001
Seaweeds as potential therapeutic interventions for the metabolic syndrome
Kumar, Senthil Arun and Brown, Lindsay. 2013. "Seaweeds as potential therapeutic interventions for the metabolic syndrome." Reviews in Endocrine and Metabolic Disorders. 14 (3), pp. 299-308. https://doi.org/10.1007/s11154-013-9254-8
Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing
Lau, Dennis H., Shipp, Nicholas J., Kelly, Darren J., Thanigaimani, Shivshankar, Neo, Melissa, Kuklik, Pawel, Lim, Han S., Zhang, Yuan, Drury, Karen, Wong, Christopher X., Chia, Nicholas H., Brooks, Anthony G., Dimitri, Hany, Saint, David A., Brown, Lindsay and Sanders, Prashanthan. 2013. "Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing." PLoS One. 8 (8), pp. 1-9. https://doi.org/10.1371/journal.pone.0072416
Modulation of leukocyte hsp70 expression by gender, menstrual cycle phase and oral contraceptives
Agnew, L. L., Colditz, I. G., Rae, K., Kauter, K. G., McFarlane, J. R. and Watson, K.. 2009. "Modulation of leukocyte hsp70 expression by gender, menstrual cycle phase and oral contraceptives." Sato, Noriyuki (ed.) 4th International Congress on Stress Responses in Biology and Medicine (CSSI 2009): Hallmarks and New Horizons in Biomedical Stress Responses. Sapporo, Japan 06 - 09 Oct 2009 Storrs, CT. United States.
Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA
Kauter, K., Ball, M., Kearney, P., Tellam, R. and McFarlane, J. R.. 2000. "Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA." Journal of Endocrinology. 166 (1), pp. 127-135.
Adenine-induced chronic kidney and cardiovascular damage in rats
Diwan, Vishal, Mistry, Anand, Gobe, Glenda and Brown, Lindsay. 2013. "Adenine-induced chronic kidney and cardiovascular damage in rats." Journal of Pharmacological and Toxicological Methods. 68 (2), pp. 197-207. https://doi.org/10.1016/j.vascn.2013.05.006
Chronic l-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats
Alam, Md. Ashraful, Kauter, Kathleen, Withers, Kerry, Sernia, Conrad and Brown, Lindsay. 2013. "Chronic l-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats." Food and Function. 4 (1), pp. 83-91. https://doi.org/10.1039/c2fo30096f
Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats
Alam, Md. Ashraful, Kauter, Kathleen and Brown, Lindsay. 2013. "Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats." Nutrients. 5 (3), pp. 637-650. https://doi.org/10.3390/nu5030637
C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling
Lim, Junxian, Iyer, Abishek, Suen, Jacky Y., Seow, Vernon, Reid, Robert C., Brown, Lindsay and Fairlie, David P.. 2013. "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling." The FASEB Journal. 27 (2), pp. 822-831. https://doi.org/10.1096/fj.12-220582
Ferulic acid improves cardiovascular and kidney structure and function in hypertensive rats
Alam, Md. Ashraful, Sernia, Conrad and Brown, Lindsay. 2013. "Ferulic acid improves cardiovascular and kidney structure and function in hypertensive rats." Journal of Cardiovascular Pharmacology. 61 (3), pp. 240-249. https://doi.org/10.1097/FJC.0b013e31827cb600
Responses to oleic, linoleic and alpha linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats
Poudyal, Hemant, Kumar, Senthil A., Iyer, Aarjit, Waanders, Jennifer, Ward, Leigh C. and Brown, Lindsay. 2013. "Responses to oleic, linoleic and alpha linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats." Journal of Nutritional Biochemistry. 24 (7), pp. 1381-1392. https://doi.org/10.1016/j.jnutbio.2012.11.006
Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats
Poudyal, Hemant, Panchal, Sunil K., Ward, Leigh C. and Brown, Lindsay. 2013. "Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats ." Journal of Nutritional Biochemistry. 24 (6), pp. 1041-1052. https://doi.org/10.1016/j.jnutbio.2012.07.014
Tocotrienols as possible treatments for obesity
Wong, Weng-Yew and Brown, Lindsay. 2013. "Tocotrienols as possible treatments for obesity." Tan, Barrie, Watson, Ronald Ross and Preedy, Victor R. (ed.) Tocotrienols: vitamin E beyond tocopherols, 2nd ed.. Boca Raton, FL. United States. CRC Press. pp. 195-208
The role of n-3 polyunsaturated fatty acids in human heart failure
Poudyal, Hemant and Brown, Lindsay. 2013. "The role of n-3 polyunsaturated fatty acids in human heart failure." Endocrine, Metabolic and Immune Disorders: Drug Targets. 13 (1), pp. 105-117. https://doi.org/10.2174/1871530311313010013
Traditional Indian medicines for metabolic syndrome
Diwan, Vishal, Poudyal, Hemant and Brown, Lindsay. 2012. "Traditional Indian medicines for metabolic syndrome." Essa, M. Mohamed, Manickavasagan, A. and Sukumar, E. (ed.) Natural products and their active compounds on disease prevention. Hauppauge, NY. United States . Nova Science Publishers. pp. 1-21
Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats
Wong, Weng-Yew, Poudyal, Hemant, Ward, Leigh C. and Brown, Lindsay. 2012. "Tocotrienols reverse cardiovascular, metabolic and liver changes in high carbohydrate, high fat diet-fed rats." Nutrients. 4 (10), pp. 1527-1541. https://doi.org/10.3390/nu4101527
Endurance exercise in a rat model of metabolic syndrome
Cameron, Isabelle, Alam, Mohammed Ashraful, Wang, Jianxiong and Brown, Lindsay. 2012. "Endurance exercise in a rat model of metabolic syndrome." Canadian Journal of Physiology and Pharmacology. 90 (11), pp. 1490-1497. https://doi.org/10.1139/y2012-097
Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes
Poudyal, Hemant, Panchal, Sunil K., Ward, Leigh C., Waanders, Jennifer and Brown, Lindsay. 2012. "Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes ." American Journal of Physiology: Endocrinology and Metabolism. 302 (12), pp. 1472-1482. https://doi.org/10.1152/ajpendo.00102.2012
Caffeine attenuates metabolic syndrome in diet-induced obese rats
Panchal, Sunil K., Wong, Weng-Yew, Kauter, Kate, Ward, Leigh C. and Brown, Lindsay. 2012. "Caffeine attenuates metabolic syndrome in diet-induced obese rats." Nutrition. 28 (10), pp. 1055-1062. https://doi.org/10.1016/j.nut.2012.02.013
An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats
Iyer, Abishek, Lim, Junxian, Poudyal, Hemant, Reid, Robert C., Suen, Jacky Y., Webster, Julie, Prins, Johannes B., Whitehead, Jonathan P., Fairlie, David P. and Brown, Lindsay. 2012. "An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats." Diabetes. 61 (9), pp. 2320-2329. https://doi.org/10.2337/db11-1179
Lysine acetylation in obesity, diabetes and metabolic disease
Iyer, Abishek, Fairlie, David P. and Brown, Lindsay. 2012. "Lysine acetylation in obesity, diabetes and metabolic disease ." Immunology and Cell Biology. 90 (1), pp. 39-46. https://doi.org/10.1038/icb.2011.99
Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats
Panchal, Sunil K., Poudyal, Hemant, Waanders, Jennifer and Brown, Lindsay. 2012. "Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats ." The Journal of Nutrition. 142 (4), pp. 690-697. https://doi.org/10.3945/jn.111.153577
Lipid redistribution by alpha linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats
Poudyal, Hemant, Panchal, Sunil K., Waanders, Jennifer, Ward, Leigh and Brown, Lindsay. 2012. "Lipid redistribution by alpha linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats." Journal of Nutritional Biochemistry. 23 (2), pp. 153-162. https://doi.org/10.1016/j.jnutbio.2010.11.011
The effects of immunosuppressants on vascular function, systemic oxidative stress and inflammation in rats
Shing, Cecilia M., Fassett, Robert G., Brown, Lindsay and Coombes, Jeff S.. 2012. "The effects of immunosuppressants on vascular function, systemic oxidative stress and inflammation in rats." Transplant International. 25 (3), pp. 337-346. https://doi.org/10.1111/j.1432-2277.2011.01420.x
Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats
Panchal, Sunil K., Poudyal, Hemant and Brown, Lindsay. 2012. "Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats ." The Journal of Nutrition. 142 (6), pp. 1026-1032. https://doi.org/10.3945/jn.111.157263
Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling
Alam, Md. Ashraful, Uddin, Shaikh Jamal and Brown, Lindsay. 2012. "Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling ." Rahman, Atta (ed.) Bioactive natural products. Amsterdam, Netherlands. Elsevier. pp. 159-190
Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats
Mesripour, Azadeh, Iyer, Abishek and Brown, Lindsay. 2012. "Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats." Basic and Clinical Pharmacology and Toxicology. 111 (2), pp. 75-80. https://doi.org/10.1111/j.1742-7843.2012.00860.x
Piperine attenuates cardiovascular, liver and metabolic changes in high carbohydrate, high fat-fed rats
Diwan, Vishal, Poudyal, Hemant and Brown, Lindsay. 2013. "Piperine attenuates cardiovascular, liver and metabolic changes in high carbohydrate, high fat-fed rats ." Cell Biochemistry and Biophysics. 67 (2), pp. 297-304. https://doi.org/10.1007/s12013-011-9306-1
Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats
Panchal, Sunil K., Ward, Leigh and Brown, Lindsay. 2013. "Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats." European Journal of Nutrition. 52 (2), pp. 559-568. https://doi.org/10.1007/s00394-012-0358-9
Cardioprotective and hepatoprotective effects of ellagitannins from European oak bark (Quercus petraea L.) extract in rats
Panchal, Sunil K. and Brown, Lindsay. 2013. "Cardioprotective and hepatoprotective effects of ellagitannins from European oak bark (Quercus petraea L.) extract in rats." European Journal of Nutrition. 52 (1), pp. 397-408. https://doi.org/10.1007/s00394-011-0277-1
Gender differences in metabolic syndrome - a key research issue
Iyer, Abishek, Kauter, Kathleen and Brown, Lindsay. 2011. "Gender differences in metabolic syndrome - a key research issue." Endocrine, Metabolic and Immune Disorders: Drug Targets. 11 (3), pp. 182-188.
Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity
Poudyal, Hemant and Brown, Lindsay. 2011. "Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity." Endocrine, Metabolic and Immune Disorders: Drug Targets. 11 (3), pp. 217-231.
Nutrapharmacology of tocotrienols for metabolic syndrome
Wong, Weng-Yew and Brown, Lindsay. 2011. "Nutrapharmacology of tocotrienols for metabolic syndrome ." Current Pharmaceutical Design. 17 (21), pp. 2206-2214. https://doi.org/10.2174/138161211796957445
Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action
Poudyal, Hemant, Panchal, Sunil K., Diwan, Vishal and Brown, Lindsay. 2011. "Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action." Progress in Lipid Research. 50 (4), pp. 372-387. https://doi.org/10.1016/j.plipres.2011.06.003
Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats
Iyer, Abishek, Woodruff, Trent M., Wu, Mike C. L., Stylianou, Con, Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay. 2011. "Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats ." Journal of Cardiovascular Pharmacology. 58 (5), pp. 479-486. https://doi.org/10.1097/FJC.0b013e31822a7a09
Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats
Iyer, Abishek, Kauter, Kathleen, Alam, Md. Ashraful, Hwang, Sung Hee, Morisseau, Christophe, Hammock, Bruce D. and Brown, Lindsay. 2012. "Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats." Experimental Diabetes Research. 2012, pp. 1-11. https://doi.org/10.1155/2012/758614
Chronic b-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat
Chan, Vincent, Fenning, Andrew, Hoey, Andrew and Brown, Lindsay. 2011. "Chronic b-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat." Journal of Cardiovascular Pharmacology. 58 (4), pp. 424-431. https://doi.org/10.1097/FJC.0b013e3182283c78
Coffee and caffeine attenuate symptoms of metabolic syndrome in diet-induced obese rats
Panchal, S. and Brown, L.. 2012. "Coffee and caffeine attenuate symptoms of metabolic syndrome in diet-induced obese rats." 2012 Australian & New Zealand Obesity Society Annual Scientific Meeting. New Zealand 01 Oct 2012 Netherlands. https://doi.org/10.1016/j.orcp.2012.08.039
Echinacea induced hsp70 alterations in leukocytes
Agnew, L., Matthias, A., Shipp, C., Kauter, K., Bone, K., Watson, K. and Lehmann, R.. 2010. "Echinacea induced hsp70 alterations in leukocytes." Melzig, Matthias F. and Kolodziej, Herbert (ed.) 7th Tannin Conference/58th International Congress and Annual Meeting of the Society for Medicinal Plant Product Research. Berlin, Germany 29 Aug - 02 Sep 2010 Stuttgart, Germany. https://doi.org/10.1055/s-0030-1264927
The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes
Wei, Michael, Ong, Leslie, Smith, Maree, Ross, Fraser B., Schmid, Katrina, Hoey, Andrew, Burstow, Darryl and Brown, Lindsay. 2003. "The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes." Heart Lung and Circulation. 12 (1), pp. 44-50. https://doi.org/10.1046/j.1444-2892.2003.00160.x
Attenuation of Cardiovascular Remodeling in DOCA-Salt Rats by the Vasopeptidase Inhibitor, Omapatrilat
Loch, David, Hoey, Andrew and Brown, Lindsay. 2006. "Attenuation of Cardiovascular Remodeling in DOCA-Salt Rats by the Vasopeptidase Inhibitor, Omapatrilat ." Clinical and Experimental Hypertension. 28 (5), pp. 475-488. https://doi.org/10.1080/10641960600798754
Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle
Woolf, Peter James, Lu, Sai, Cornford-Nairn, Renee A., Watson, Michael, Xiao, Xiao-Hui, Holroyd, Sean, Brown, Lindsay and Hoey, Andrew. 2006. "Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle." American Journal of Physiology: Heart and Circulatory Physiology. 290 (6), pp. H2439-H2445. https://doi.org/10.1152/ajpheart.00844.2005
Cardiac extracellular matrix: a dynamic entity
Brown, Lindsay. 2005. "Cardiac extracellular matrix: a dynamic entity." American Journal of Physiology: Heart and Circulatory Physiology. 289 (3), pp. H973-H974. https://doi.org/10.1152/ajpheart.00443.2005
Increased calcium influx mediates increased cardiac stiffness in hyperthyroid rats
Levick, Scott, Fenning, Andrew and Brown, Lindsay. 2005. "Increased calcium influx mediates increased cardiac stiffness in hyperthyroid rats." Cell Biochemistry and Biophysics. 43 (1), pp. 53-60.
Antioxidant supplementation enhances erythrocyte antioxidant status and attenuates cyclosporine-induced vascular dysfunction
Lexis, L. A., Fenning, A., Brown, L., Fassett, R. G. and Coombes, J. S.. 2006. "Antioxidant supplementation enhances erythrocyte antioxidant status and attenuates cyclosporine-induced vascular dysfunction." American Journal of Transplantation. 6 (1), pp. 41-49. https://doi.org/10.1111/j.1600-6143.2005.01154.x
Therapeutic interventions: an Islamic perspective
Rahman, Mohammad Tariqur, Nazer, Reeza, Brown, Lindsay, Shogar, Ibrahim and Bouzenita, Anke Iman. 2008. "Therapeutic interventions: an Islamic perspective." IMA Journal. 40 (2), pp. 60-68.
Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats
Levick, Scott, Loch, David, Rolfe, Barbara E., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay. 2006. "Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats ." Journal of Immunology. 176 (11), pp. 7000-7007.
Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress
Lim, Chin Leong, Wilson, Gary, Brown, Lindsay, Coombes, Jeff S. and Mackinnon, Laurel T.. 2007. "Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress ." American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 292 (1), pp. R186-R194. https://doi.org/10.1152/ajpregu.00921.2005
Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease
Percy, C. J., Brown, Lindsay, Power, D. A., Johnson, David W. and Gobe, Glenda C.. 2009. "Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease." Mechanisms of Ageing and Development. 130 (3), pp. 129-138. https://doi.org/10.1016/j.mad.2008.10.003
Chronic dietary L-arginine down-regulates adenosine receptor and nitric oxide synthase expression in rat heart
Rose'Meyer, Roselyn B., Harrison, Glenn, Fenning, Andrew, Jenner, Tamsin and Brown, Lindsay. 2008. "Chronic dietary L-arginine down-regulates adenosine receptor and nitric oxide synthase expression in rat heart." Basic and Clinical Pharmacology and Toxicology. 102 (5), pp. 459-465. https://doi.org/10.1111/j.1742-7843.2008.00209.x
Resistance to ocular antibiotics: an overview
Brown, Lindsay. 2007. "Resistance to ocular antibiotics: an overview ." Clinical and Experimental Optometry. 90 (4), pp. 258-262. https://doi.org/10.1111/j.1444-0938.2007.00154.x
Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats
Panchal, Sunil K., Poudyal, Hemant, Arumugam, Thiruma V. and Brown, Lindsay. 2011. "Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats ." The Journal of Nutrition. 141 (6), pp. 1062-1069. https://doi.org/10.3945/jn.111.137877
High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats
Panchal, Sunil K., Poudyal, Hemant, Iyer, Abishek, Nazer, Reeza, Alam, Md. Ashraful, Diwan, Vishal, Kauter, Kathleen, Sernia, Conrad, Campbell, Fiona, Ward, Leigh, Gobe, Glenda, Fenning, Andrew and Brown, Lindsay. 2011. "High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats." Journal of Cardiovascular Pharmacology. 57 (5), pp. 611-624. https://doi.org/10.1097/FJC.0b013e3181feb90a
A regenerative antioxidant protocol of vitamin E and alpha-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats
Patel, Jatin, Matnor, Nur Azim, Iyer, Abishek and Brown, Lindsay. 2011. "A regenerative antioxidant protocol of vitamin E and alpha-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats." Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2011/120801
Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats
Chan, Vincent, Fenning, Andrew, Levick, Scott P., Loch, David, Chunduri, Prasad, Iyer, Abishek, Teo, Yi Ling, Hoey, Andrew, Wilson, Kathleen, Burstow, Darryl and Brown, Lindsay. 2011. "Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats." Journal of Cardiovascular Pharmacology. 57 (4), pp. 469-478. https://doi.org/10.1097/FJC.0b013e3182102c3b
Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats
Chan, Vincent, Fenning, Andrew, Iyer, Abishek, Hoey, Andrew and Brown, Lindsay. 2011. "Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats." Current Pharmaceutical Biotechnology. 12 (3), pp. 429-436. https://doi.org/10.2174/138920111794480552
Rodent models for metabolic syndrome research
Panchal, Sunil K. and Brown, Lindsay. 2011. "Rodent models for metabolic syndrome research." Journal of Biomedicine and Biotechnology. https://doi.org/10.1155/2011/351982
Leptin is a signal of fetal adiposity in pregnant ewes fed at or above maintenance energy requirements
Muhlhausler, B. S., Roberts, C. T., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2002. "Leptin is a signal of fetal adiposity in pregnant ewes fed at or above maintenance energy requirements." 49th Annual Meeting Society for Gynecologic Investigation. Los Angeles, United States 20 - 23 Mar 2002 United States.
Circulating leptin concentrations are positively related to leptin messenger RNA expression in the adipose tissue of fetal sheep in the pregnant ewe fed at or below maintenance energy requirements during late gestation
Yuen, B. S. J., Owens, P. C., McFarlane, J. R., Symonds, M. E., Edwards, L. J., Kauter, K. G. and McMillen, I. C.. 2002. "Circulating leptin concentrations are positively related to leptin messenger RNA expression in the adipose tissue of fetal sheep in the pregnant ewe fed at or below maintenance energy requirements during late gestation." Biology of Reproduction. 67 (3), pp. 911-916. https://doi.org/10.1095/biolreprod.101.002931
Unusual susceptibility of sheep selected for resistance to internal parasites
Gray, G. D., Gill, H. S., Kauter, K. G., Burgess, S. K. and Douglas-Hill, A.. 1994. "Unusual susceptibility of sheep selected for resistance to internal parasites." 5th World Congress on Genetics Applied to Livestock Production. Guelph, Canada 15 Sep 1994 Canada.
Echinacea induced hsp70 alterations in leukocytes
Agnew, L. L., Matthias, A., Shipp, C., Kauter, K. G., Bone, K. M., Watson, K. and Lehmann, R. P.. 2010. "Echinacea induced hsp70 alterations in leukocytes." AHMR 2010: 5th Australian Health and Medical Research Congress. Melbourne, Australia 14 - 18 Nov 2010 Australia.
Comparison of purple carrot juice and b-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome
Poudyal, Hemant, Panchal, Sunil and Brown, Lindsay. 2010. "Comparison of purple carrot juice and b-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome." The British Journal of Nutrition: an international journal of nutritional science. 104 (9), pp. 1322-1332. https://doi.org/10.1017/S0007114510002308
Lipid mediators and inflammation in glucose intolerance and insulin resistance
Iyer, Abishek and Brown, Lindsay. 2010. "Lipid mediators and inflammation in glucose intolerance and insulin resistance." Drug Discovery Today: Disease Mechanisms. 7 (3-4), pp. e191-e197. https://doi.org/10.1016/j.ddmec.2010.12.001
The DOCA-salt hypertensive rat as a model of cardiovascular oxidative and inflammatory stress
Iyer, Abishek, Chan, Vincent and Brown, Lindsay. 2010. "The DOCA-salt hypertensive rat as a model of cardiovascular oxidative and inflammatory stress." Current Cardiology Reviews. 6 (4), pp. 291-297. https://doi.org/10.2174/157340310793566109
Green tea attenuates cardiovascular remodeling and metabolic symptoms in high carbohydrate-fed rats
Rickman, Celestine, Iyer, Abishek, Chan, Vincent and Brown, Lindsay. 2010. "Green tea attenuates cardiovascular remodeling and metabolic symptoms in high carbohydrate-fed rats." Current Pharmaceutical Biotechnology. 11 (8), pp. 881-886.
Hair cortisol concentration differs across site and person: localisation and consistency of responses to a brief pain stressor
Sharpley, C. F., Kauter, K. G. and McFarlane, J. R.. 2010. "Hair cortisol concentration differs across site and person: localisation and consistency of responses to a brief pain stressor." Physiological Research. 59 (6), pp. 979-983.
Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator activated receptor y; (PPARy;)mRNA expression in visceral fat in the lamb
Duffield, Jaime A., Vuocolo, Tony, Tellam, Ross, McFarlane, Jim R., Kauter, Kate G., Muhlhausler, B. S. and McMillen, I. Caroline. 2009. "Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator activated receptor y; (PPARy;)mRNA expression in visceral fat in the lamb." Pediatric Research. 66 (1), pp. 59-65. https://doi.org/10.1203/PDR.0b013e3181a7c121
The cardiovascular nutrapharmacology of resveratrol: pharmacokinetics, molecular mechanisms and therapeutic potential
Kroon, Paul A., Iyer, Abishek, Chunduri, Prasad, Chan, Vincent and Brown, Lindsay. 2010. "The cardiovascular nutrapharmacology of resveratrol: pharmacokinetics, molecular mechanisms and therapeutic potential ." Current Medicinal Chemistry. 17 (23), pp. 2442-2455. https://doi.org/10.2174/092986710791556032
L-carnitine attenuates cardiac impairment but not vascular dysfunction in DOCA-salt hypertensive rats
O'Brien, Daniel, Chunduri, Prasad, Iyer, Abishek and Brown, Lindsay. 2010. "L-carnitine attenuates cardiac impairment but not vascular dysfunction in DOCA-salt hypertensive rats ." Basic and Clinical Pharmacology and Toxicology. 106 (4), pp. 296-301. https://doi.org/10.1111/j.1742-7843.2009.00480.x
An initial exploration of in vivo hair cortisol responses to a brief pain stressor: latency, localization and independence effects
Sharpley, C. F., Kauter, K. G. and McFarlane, J. R.. 2009. "An initial exploration of in vivo hair cortisol responses to a brief pain stressor: latency, localization and independence effects." Physiological Research. 58 (5), pp. 757-761.
Rutin attenuates non-alcoholic steatohepatitis in high carbohydrate-high fat diet-fed rats
Panchal, S. K., Poudyal, H., Arumugam, T. V. and Brown, L.. 2011. "Rutin attenuates non-alcoholic steatohepatitis in high carbohydrate-high fat diet-fed rats." 46th Annual Meeting of the European Association for the Study of the Liver. Berlin 30 Mar - 03 Apr 2011 Netherlands. https://doi.org/10.1016/S0168-8278(11)60097-4
An investigation of hair cortisol concentration across body sites and within hair shaft
Sharpley, Christopher F., Kauter, Kathleen G. and McFarlane, James R.. 2010. "An investigation of hair cortisol concentration across body sites and within hair shaft." Clinical Medicine Insights: Endocrinology and Diabetes. 3, pp. 17-23. https://doi.org/10.4137/CMED.S4465
Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2
Herath, Chandana B., Lubel, John S., Jia, Zhiyuan, Velkoska, Elena, Casley, David, Brown, Lindsay, Tikellis, Chris, Burrell, Louise M. and Angus, Peter W.. 2009. "Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2." American Journal of Physiology: Gastrointestinal and Liver Physiology. 297 (1), pp. G98-G106. https://doi.org/10.1152/ajpgi.00045.2009
Diurnal variation in peripheral (hair) vs central (saliva) HPA axis cortisol concentrations
Sharpley, Christopher F., Kauter, Kathleen G. and McFarlane, James R.. 2010. "Diurnal variation in peripheral (hair) vs central (saliva) HPA axis cortisol concentrations." Clinical Medicine Insights: Endocrinology and Diabetes. 3, pp. 9-16. https://doi.org/10.4137/CMED.S4350
Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats: research paper
Iyer, Abishek, Fenning, Andrew, Lim, Junxian, Le, Giang T., Reid, Robert C., Halili, Maria A., Fairlie, David P. and Brown, Lindsay. 2010. "Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats: research paper." British Journal of Pharmacology. 159 (7), pp. 1408-1417. https://doi.org/10.1111/j.1476-5381.2010.00637.x
Inflammatory lipid mediators in adipocyte function and obesity
Iyer, Abishek, Prins, Johannes B., Fairlie, David P., Hammock, Bruce D. and Brown, Lindsay. 2010. "Inflammatory lipid mediators in adipocyte function and obesity." Nature Reviews Endocrinology. 6 (2), pp. 71-82. https://doi.org/10.1038/nrendo.2009.264
Fetal leptin is a signal of fat mass independent of maternal nutrition in ewes fed at or above maintenance energy requirements
Muhlhausler, B. S., Roberts, C. T., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2002. "Fetal leptin is a signal of fat mass independent of maternal nutrition in ewes fed at or above maintenance energy requirements." Biology of Reproduction. 67 (2), pp. 493-499. https://doi.org/10.1095/biolreprod67.2.493
Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies
Edwards, L. J., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2005. "Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies." American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 288 (1), pp. R39-R45. https://doi.org/10.1152/ajpregu.00127.2004
Is mycophenolate more than just an immunosuppressant? An overview
Iyer, Abishek and Brown, Lindsay. 2009. "Is mycophenolate more than just an immunosuppressant? An overview." Indian Journal of Biochemistry and Biophysics. 46 (1), pp. 25-30.
Evaluation of the chronic complications of diabetes in a high fructose diet in rats
Patel, Jatin, Iyer, Abishek and Brown, Lindsay. 2009. "Evaluation of the chronic complications of diabetes in a high fructose diet in rats." Indian Journal of Biochemistry and Biophysics. 46 (1), pp. 66-72.
The biological responses to resveratrol and other polyphenols from alcoholic beverages
Brown, Lindsay, Kroon, Paul A., Das, Dipak K., Das, Samarjit, Tosaki, Arpad, Chan, Vincent, Singer, Manfred V. and Feick, Peter. 2009. "The biological responses to resveratrol and other polyphenols from alcoholic beverages." Alcoholism: Clinical and Experimental Research. 33 (9), pp. 1513-1523. https://doi.org/10.1111/j.1530-0277.2009.00989.x
Potential health benefits of Indian spices in the symptoms of metabolic syndrome: a review
Iyer, Abishek, Panchal, Sunil, Poudyal, Hemant and Brown, Lindsay. 2009. "Potential health benefits of Indian spices in the symptoms of metabolic syndrome: a review." Indian Journal of Biochemistry and Biophysics. 46 (6), pp. 467-481.
Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation
Muhlhausler, B. S., Adam, C. L., Marrocco, E. M., Findlay, P. A., Roberts, C. T., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2005. "Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation." The Journal of Physiology. 565 (1), pp. 185-195. https://doi.org/10.1113jphysiol.2004.079079
Fermented wheat germ extract extract (Avemar) in the treatment of cardiac remodelling and metabolic symptoms in rats
Iyer, Abishek and Brown, Lindsay. 2009. "Fermented wheat germ extract extract (Avemar) in the treatment of cardiac remodelling and metabolic symptoms in rats." Evidence-Based Complementary and Alternative Medicine. 2011, pp. 1-9. https://doi.org/10.1093/ecam/nep090
Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy
Muhlhausler, B. S., Roberts, C. T., Yuen, B. S. J., Marrocco, E., Budge, H., Symonds, M. E., McFarlane, J. R., Kauter, K. G., Stagg, P., Pearse, J. K. and McMillen, I. C.. 2003. "Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy." Endocrinology. 144 (11), pp. 4947-4954. https://doi.org/10.1210/en.2003-0555
Leptin alters the structural and functional characteristics of adipose tissue before birth
Yuen, B. S. J., Owens, P. C., Muhlhausler, B. S., Roberts, C. T., Symonds, M. E., Keisler, D. H., McFarlane, J. R., Kauter, K. G., Evens, Y. and McMillen, I. C.. 2003. "Leptin alters the structural and functional characteristics of adipose tissue before birth." The FASEB Journal. 17 (9), pp. 1102-1104. https://doi.org/10.1096/fj.02-0756fje
Effects of leptin on fetal plasma adrenocorticotropic hormone and cortisol concentrations and the timing of parturition in the sheep
Yuen, B. S. J., Owens, P. C., Symonds, M. E., Keisler, D. H., McFarlane, J. R., Kauter, K. G. and McMillen, I. C.. 2004. "Effects of leptin on fetal plasma adrenocorticotropic hormone and cortisol concentrations and the timing of parturition in the sheep." Biology of Reproduction. 70 (6), pp. 1650-1657. https://doi.org/10.1095/biolreprod.103.025254
Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat
Campbell, Fiona, Atwell, Rick, Fenning, Andrew, Hoey, Andrew and Brown, Lindsay. 2004. "Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat." Toxicon. 43 (7), pp. 743-750. https://doi.org/10.1016/j.toxicon.2004.02.025
Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats
Poudyal, Hemant, Campbell, Fiona and Brown, Lindsay. 2010. "Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats." The Journal of Nutrition. 140 (5), pp. 946-953. https://doi.org/10.3945/jn.109.117812
Rosuvastatin attenuates heart failure and cardiac remodelling in the ageing spontaneously hypertensive rat
Loch, David, Chan, Vincent, Hoey, Andrew and Brown, Lindsay. 2009. "Rosuvastatin attenuates heart failure and cardiac remodelling in the ageing spontaneously hypertensive rat." Basic and Clinical Pharmacology and Toxicology. 105 (4), pp. 262-270. https://doi.org/10.1111/j.1742-7843.2009.00440.x
Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase
Loch, David, Hoey, Andrew, Morisseau, Christophe, Hammock, Bruce O. and Brown, Lindsay. 2007. "Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase." Cell Biochemistry and Biophysics. 47 (1), pp. 87-98.
Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats
Loch, David, Levick, Scott, Hoey, Andrew and Brown, Lindsay. 2006. "Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats." Journal of Cardiovascular Pharmacology. 47 (3), pp. 396-404.
Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats
Chan, Vincent, Hoey, Andrew and Brown, Lindsay. 2006. "Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats." British Journal of Pharmacology. 148 (7), pp. 902-908. https://doi.org/10.1038/sj.bjp.0706801
L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats
Fenning, Andrew, Harrison, Glenn, Rose'Meyer, Roselyn, Hoey, Andrew and Brown, Lindsay. 2005. "L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats." American Journal of Physiology: Heart and Circulatory Physiology. 289 (4), pp. H1408-H1416. https://doi.org/10.1152/ajpheart.00140.2005
Reversal of cardiac dysfunction by selective ET-A receptor antagonism
Allan, Anthony, Fenning, Andrew, Levick, Scott, Hoey, Andrew and Brown, Lindsay. 2005. "Reversal of cardiac dysfunction by selective ET-A receptor antagonism." British Journal of Pharmacology. 146 (6), pp. 846-853. https://doi.org/10.1038/sj.bjp.0706384