A regenerative antioxidant protocol of vitamin E and alpha-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats
Article
Article Title | A regenerative antioxidant protocol of vitamin E and alpha-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats |
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ERA Journal ID | 34155 |
Article Category | Article |
Authors | Patel, Jatin (Author), Matnor, Nur Azim (Author), Iyer, Abishek (Author) and Brown, Lindsay (Author) |
Journal Title | Evidence-Based Complementary and Alternative Medicine |
Number of Pages | 8 |
Year | 2011 |
Publisher | Hindawi Publishing Corporation |
Place of Publication | New York, NY. USA |
ISSN | 1741-427X |
1741-4288 | |
Digital Object Identifier (DOI) | https://doi.org/10.1155/2011/120801 |
Web Address (URL) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062110/?tool=pubmed |
Abstract | Type 2 diabetes is a major cause of cardiovascular disease. We have determined whether the metabolic and cardiovascular changes induced by a diet high in fructose in young adult male Wistar rats could be prevented or reversed by chronic intervention with natural antioxidants. We administered a regenerative antioxidant protocol using two natural compounds: α-lipoic acid together with vitamin E (α-tocopherol alone or a tocotrienol-rich fraction), given as either a prevention or reversal protocol in the food. These rats developed glucose intolerance, hypertension, and increased collagen deposition in the heart together with an increased ventricular stiffness. Treatment with a fixed combination of vitamin E (either α-tocopherol or tocotrienol-rich fraction, 0.84 g/kg food) and α-lipoic acid (1.6 g/kg food) normalized glucose tolerance, blood pressure, cardiac collagen deposition, and ventricular stiffness in both prevention and reversal protocols in these fructose-fed rats. These results suggest that adequate antioxidant therapy |
Keywords | regenerative antioxidants; diabetes; type 2; fructose; heart disease |
ANZSRC Field of Research 2020 | 320507. Metabolic medicine |
321401. Basic pharmacology | |
320101. Cardiology (incl. cardiovascular diseases) | |
Public Notes | Copyright © 2011 Jatin Patel et al. This is an open access article distributed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Byline Affiliations | University of Queensland |
Department of Biological and Physical Sciences | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q0qx6/a-regenerative-antioxidant-protocol-of-vitamin-e-and-alpha-lipoic-acid-ameliorates-cardiovascular-and-metabolic-changes-in-fructose-fed-rats
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Patel_Matnor_Iyer_Brown_EBCAM_2011_PV.pdf | ||
License: CC BY 4.0 | ||
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