Cyanidin 3-glucoside from Queen Garnet plums and purple carrots attenuates DSS-induced inflammatory bowel disease in rats
Article
Article Title | Cyanidin 3-glucoside from Queen Garnet plums and purple carrots attenuates DSS-induced inflammatory bowel disease in rats |
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ERA Journal ID | 124610 |
Article Category | Article |
Authors | Ghattamaneni, Naga K.R. (Author), Panchal, Sunil K. (Author) and Brown, Lindsay (Author) |
Journal Title | Journal of Functional Foods |
Journal Citation | 56, pp. 194-203 |
Number of Pages | 10 |
Year | 2019 |
Place of Publication | Netherlands |
ISSN | 1756-4646 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jff.2019.01.028 |
Web Address (URL) | http://www.sciencedirect.com/science/article/pii/S1756464619300283 |
Abstract | We have investigated whether dextran sodium sulphate (DSS)-induced inflammatory bowel disease (IBD) in rats can be ameliorated by intervention with cyanidin 3-glucoside (C3G). Rats were given either normal water (C) or 0.5% DSS (D) in drinking water for 12 weeks. C3G 8 mg/kg/day as Queen Garnet plum (Q) juice, purple carrot (P) juice or pure compound was added in food for final 6 weeks to C rats to give CQ, CP and CC groups, and to D rats to give DQ, DP and DC groups. No symptoms of IBD were observed in C, CQ, CP or CC rats. D rats had bloody diarrhoea, ileal and colonic mucosal atrophy, and inflammation. Compared to D rats, DQ, DP and DC rats showed improved stool consistency (P < 0.0001) and bleeding (P < 0.0001), reduced ileum (P < 0.0001) and colon inflammation (P < 0.0001), with no changes in gut microbiota. Thus, supplementation with C3G-containing foods may ameliorate the symptoms of IBD. |
Keywords | inflammatory bowel disease; dextran sodium sulphate; anthocyanins; Cyanidin 3-glucoside; Queen Garnet plum; purple carrot |
ANZSRC Field of Research 2020 | 321004. Nutritional science |
321401. Basic pharmacology | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Centre for Health Research |
Functional Foods Research Group | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q5334/cyanidin-3-glucoside-from-queen-garnet-plums-and-purple-carrots-attenuates-dss-induced-inflammatory-bowel-disease-in-rats
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