Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats
Article
Article Title | Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats |
---|---|
ERA Journal ID | 13658 |
Article Category | Article |
Authors | Panchal, Sunil K. (Author), Poudyal, Hemant (Author), Arumugam, Thiruma V. (Author) and Brown, Lindsay (Author) |
Journal Title | The Journal of Nutrition |
Journal Citation | 141 (6), pp. 1062-1069 |
Number of Pages | 8 |
Year | 2011 |
Place of Publication | Bethesda, MD. USA |
ISSN | 0022-3166 |
1541-6100 | |
Digital Object Identifier (DOI) | https://doi.org/10.3945/jn.111.137877 |
Abstract | Metabolic syndrome (obesity, diabetes, and hypertension) increases hepatic and cardiovascular damage. This study investigated preventive or reversal responses to rutin in high-carbohydrate, high-fat diet-fed rats as a model of metabolic syndrome. Rats were divided into 6 groups: 2 groups were fed a corn starch-rich diet for 8 or 16 wk, 2 groups were fed a high-carbohydrate, high-fat diet for 8 or 16 wk, and 2 groups received rutin (1.6 g/kg diet) in either diet for the last 8 wk only of the 16-wk protocol. Metabolic changes and hepatic and cardiovascular structure and function were then evaluated in these rats. The corn starch-rich diet contained 68% carbohydrate (mainly cornstarch) and 0.7% fat, whereas the highcarbohydrate, high-fat diet contained 50% carbohydrate (mainly fructose) and 24% fat (mainly beef tallow) along with 25% fructose in drinking water (total 68% carbohydrate using mean food and water intakes). The high-carbohydrate, high-fat diet produced obesity, dyslipidemia, hypertension, impaired glucose tolerance, hepatic steatosis, infiltration of inflammatory cells in the liver and the heart, higher cardiac stiffness, endothelial dysfunction, and higher plasma markers of oxidative stress with lower expression of markers for oxidative stress and apoptosis in the liver. Rutin reversed or prevented metabolic changes such as abdominal fat pads and glucose tolerance, reversed or prevented changes in hepatic and cardiovascular structure and function, reversed oxidative stress and inflammation in the liver and heart, and normalized expression of liver markers. These results suggest a non-nutritive role for rutin to attenuate chronic changes in metabolic syndrome. |
Keywords | liver disease; cardiovascular disease; obesity; diabetes; hypertension |
ANZSRC Field of Research 2020 | 420899. Traditional, complementary and integrative medicine not elsewhere classified |
320209. Gastroenterology and hepatology | |
320101. Cardiology (incl. cardiovascular diseases) | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Department of Biological and Physical Sciences |
University of Queensland | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q0w34/rutin-attenuates-metabolic-changes-nonalcoholic-steatohepatitis-and-cardiovascular-remodeling-in-high-carbohydrate-high-fat-diet-fed-rats
1992
total views9
total downloads1
views this month0
downloads this month