Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats
Article
Article Title | Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats |
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ERA Journal ID | 211188 |
Article Category | Article |
Authors | Bhandarkar, Nikhil S., Mouatt, Peter, Majzoub, Marwan E., Thomas, Torsten, Brown, Lindsay and Panchal, Sunil K. |
Journal Title | Pathogens |
Journal Citation | 10 (11) |
Article Number | 1369 |
Number of Pages | 16 |
Year | 2021 |
Publisher | MDPI AG |
Place of Publication | Switzerland |
ISSN | 2076-0817 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/pathogens10111369 |
Web Address (URL) | https://www.mdpi.com/2076-0817/10/11/1369 |
Abstract | Waste from food production can be re-purposed as raw material for usable products to decrease industrial waste. Coffee pulp is 29% of the dry weight of coffee cherries and contains caffeine, chlorogenic acid, trigonelline, diterpenes and fibre. We investigated the attenuation of signs of metabolic syndrome induced by high-carbohydrate, high-fat diet in rats by dietary supplemen-tation with 5% freeze-dried coffee pulp for the final 8 weeks of a 16-week protocol. Coffee pulp decreased body weight, feed efficiency and abdominal fat; normalised systolic blood pressure, left ventricular diastolic stiffness, and plasma concentrations of triglycerides and non-esterified fatty acids; and improved glucose tolerance in rats fed high-carbohydrate, high-fat diet. Further, the gut microbiota was modulated with high-carbohydrate, high-fat diet and coffee pulp supplementation and 14 physiological parameters were correlated with the changes in bacterial community structures. This study suggested that coffee pulp, as a waste from the coffee industry, is useful as a functional food for improving obesity-associated metabolic, cardiovascular and liver structure and function, and gut microbiota. |
Keywords | Chlorogenic acid; Coffee pulp; Gut microbiota; High-carbohydrate; High-fat; Metabolic syndrome; Obesity |
Byline Affiliations | University of Southern Queensland |
Southern Cross University | |
University of New South Wales |
https://research.usq.edu.au/item/w5y39/coffee-pulp-a-by-product-of-coffee-production-modulates-gut-microbiota-and-improves-metabolic-syndrome-in-high-carbohydrate-high-fat-diet-fed-rats
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