Nannochloropsis oceanica as a Microalgal Food Intervention in Diet-Induced Metabolic Syndrome in Rats
Article
Article Title | Nannochloropsis oceanica as a Microalgal Food Intervention in Diet-Induced Metabolic Syndrome in Rats |
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ERA Journal ID | 211152 |
Article Category | Article |
Authors | du Preez, Ryan, Majzoub, Marwan E., Thomas, Torsten, Panchal, Sunil K. and Brown, Lindsay |
Journal Title | Nutrients |
Journal Citation | 13 (11) |
Article Number | 3991 |
Number of Pages | 15 |
Year | 2021 |
Publisher | MDPI AG |
Place of Publication | Switzerland |
ISSN | 2072-6643 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/nu13113991 |
Web Address (URL) | https://www.mdpi.com/2072-6643/13/11/3991 |
Abstract | The microalgal genus Nannochloropsis has broad applicability to produce biofuels, animal feed supplements and other value-added products including proteins, carotenoids and lipids. This study investigated a potential role of N. oceanica in the reversal of metabolic syndrome. Male Wistar rats (n = 48) were divided into four groups in a 16-week protocol. Two groups were fed either corn starch or high-carbohydrate, high-fat diets (C and H, respectively) for the full 16 weeks. The other two groups received C and H diets for eight weeks and then received 5% freeze-dried N. oceanica in these diets for the final eight weeks (CN and HN, respectively) of the protocol. The H diet was high in fructose and sucrose, together with increased saturated and trans fats. H rats developed obesity, hypertension, dyslipidaemia, fatty liver disease and left ventricular fibrosis. N. oceanica increased lean mass in CN and HN rats, possibly due to the increased protein intake, and decreased fat mass in HN rats. Intervention with N. oceanica did not change cardiovascular, liver and metabolic parameters or gut structure. The relative abundance of Oxyphotobacteria in the gut microbiota was increased. N. oceanica may be an effective functional food against metabolic syndrome as a sustainable protein source. |
Keywords | Eicosapentaenoic acid; Gut microbiota; Metabolic syndrome; Microalgae; Nannochloropsis oceanica |
Funder | University of Queensland |
Byline Affiliations | University of Southern Queensland |
University of New South Wales | |
Library Services |
https://research.usq.edu.au/item/w7510/nannochloropsis-oceanica-as-a-microalgal-food-intervention-in-diet-induced-metabolic-syndrome-in-rats
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