Modulation of tissue fatty acids by l-carnitine attenuates metabolic syndrome in diet-induced obese rats
Article
Article Title | Modulation of tissue fatty acids by l-carnitine attenuates metabolic syndrome in diet-induced obese rats |
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ERA Journal ID | 123195 |
Article Category | Article |
Authors | Panchal, Sunil K. (Author), Poudyal, Hemant (Author), Ward, Leigh C. (Author), Waanders, Jennifer (Author) and Brown, Lindsay (Author) |
Journal Title | Food and Function |
Journal Citation | 6 (8), pp. 2496-2506 |
Number of Pages | 11 |
Year | 2015 |
Place of Publication | Cambridge, United Kingdom |
ISSN | 2042-6496 |
2042-650X | |
Digital Object Identifier (DOI) | https://doi.org/10.1039/C5FO00480B |
Abstract | Obesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism. These impairments are associated with the development of cardiovascular disease and non-alcoholic fatty liver disease. Correcting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular risk and liver damage. l-Carnitine supplementation was used in this study to enhance fatty acid oxidation so as to ameliorate diet-induced disturbances in lipid metabolism. Male Wistar rats (8-9 weeks old) were fed with either corn starch or high-carbohydrate, high-fat diets for 16 weeks. Separate groups were supplemented with l-carnitine (1.2% in food) on either diet for the last 8 weeks of the protocol. High-carbohydrate, high-fat diet-fed rats showed central obesity, dyslipidaemia, hypertension, impaired glucose tolerance, hyperinsulinaemia, cardiovascular remodelling and non-alcoholic fatty liver disease. l-Carnitine supplementation attenuated these high-carbohydrate, high-fat diet-induced changes, together with modifications in lipid metabolism including the inhibition of stearoyl-CoA desaturase-1 activity, reduced storage of short-chain monounsaturated fatty acids in the tissues with decreased linoleic acid content and trans fatty acids stored in retroperitoneal fat. Thus, l-carnitine supplementation attenuated the signs of metabolic syndrome through inhibition of stearoyl-CoA desaturase-1 activity, preferential [small beta]-oxidation of some fatty acids and increased storage of saturated fatty acids and relatively inert oleic acid in the tissues. |
Keywords | metabolism, fatty acids, l-carnitine, obesity, cardiovascular remodelling |
ANZSRC Field of Research 2020 | 321004. Nutritional science |
321401. Basic pharmacology | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Institute for Agriculture and the Environment |
Kyoto University, Japan | |
University of Queensland | |
School of Health and Wellbeing | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q30q6/modulation-of-tissue-fatty-acids-by-l-carnitine-attenuates-metabolic-syndrome-in-diet-induced-obese-rats
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