Reversal of cardiac dysfunction by selective ET-A receptor antagonism
Article
Article Title | Reversal of cardiac dysfunction by selective ET-A receptor antagonism |
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ERA Journal ID | 14703 |
Article Category | Article |
Authors | Allan, Anthony (Author), Fenning, Andrew (Author), Levick, Scott (Author), Hoey, Andrew (Author) and Brown, Lindsay (Author) |
Journal Title | British Journal of Pharmacology |
Journal Citation | 146 (6), pp. 846-853 |
Number of Pages | 8 |
Year | 2005 |
Place of Publication | United Kingdom |
ISSN | 0007-1188 |
1476-5381 | |
Digital Object Identifier (DOI) | https://doi.org/10.1038/sj.bjp.0706384 |
Web Address (URL) | http://www.nature.com/bjp/journal/v146/n6/pdf/0706384a.pdf |
Abstract | 1. The effectiveness of a selective endothelin receptor-A (ET-A) antagonist, A-127722 (approximately 10 mg kg-1 day-1 as 200 mg kg-1 powdered food), to reverse existing cardiac remodelling and prevent further remodelling was tested in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. |
Keywords | endothelin, remodelling, hypertension, hypertrophy, collagen, rats |
ANZSRC Field of Research 2020 | 321405. Pharmaceutical sciences |
320803. Systems physiology | |
Public Notes | File reproduced in accordance with the copyright policy of the publisher/author. |
Byline Affiliations | University of Queensland |
Department of Biological and Physical Sciences |
https://research.usq.edu.au/item/9x8y5/reversal-of-cardiac-dysfunction-by-selective-et-a-receptor-antagonism
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