Timeline of cardiac dystrophy in 3 to 18-month-old MDX mice

Article


van Erp, Christel, Loch, David, Laws, Nicola, Trebbin, Andrea and Hoey, Andrew J.. 2010. "Timeline of cardiac dystrophy in 3 to 18-month-old MDX mice ." Muscle and Nerve. 42 (4), pp. 504-513. https://doi.org/10.1002/mus.21716
Article Title

Timeline of cardiac dystrophy in 3 to 18-month-old MDX mice

ERA Journal ID14530
Article CategoryArticle
Authorsvan Erp, Christel (Author), Loch, David (Author), Laws, Nicola (Author), Trebbin, Andrea (Author) and Hoey, Andrew J. (Author)
Journal TitleMuscle and Nerve
Journal Citation42 (4), pp. 504-513
Number of Pages10
Year2010
Place of PublicationHoboken, NJ. United States
ISSN0148-639X
1097-4598
Digital Object Identifier (DOI)https://doi.org/10.1002/mus.21716
Web Address (URL)http://onlinelibrary.wiley.com/doi/10.1002/mus.21716/pdf
Abstract

The dystrophin-deficient (mdx) mouse remains the most commonly used model for Duchenne muscular dystrophy (DMD). Mdx mice show a predominantly covert cardiomyopathy, the hallmark of which is fibrosis. We compared mdx and normal mice at six ages (3, 6, 9, 12, 15, and 18 months) using in vivo assessment of cardiac function, selective collagen staining, and measures of TGF-β mRNA, Evans blue dye infiltration, macrophage infiltration, and aortic wall thickness. Clear temporal progression was demonstrated, including early fragility of cardiomyocyte membranes, which has an unrelated impact on cardiac function but is associated with macrophage infiltration and fibrosis. Aortic wall thickness is less in older mdx mice. Mdx mice display impaired responses to inotropic challenge from a young age; this is indicative of altered adrenoreceptor function. We draw attention to the paradox of ongoing fibrosis in mdx hearts without a strong molecular signature (in the form of TGF-β mRNA expression).

Keywordsmdx mouse heart; dystrophin; TGF-β; cardiac fibrosis
ANZSRC Field of Research 2020320602. Medical biotechnology diagnostics (incl. biosensors)
320803. Systems physiology
320101. Cardiology (incl. cardiovascular diseases)
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsCentre for Systems Biology
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q12y2/timeline-of-cardiac-dystrophy-in-3-to-18-month-old-mdx-mice

  • 1901
    total views
  • 10
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Chronic b-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat
Chan, Vincent, Fenning, Andrew, Hoey, Andrew and Brown, Lindsay. 2011. "Chronic b-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat." Journal of Cardiovascular Pharmacology. 58 (4), pp. 424-431. https://doi.org/10.1097/FJC.0b013e3182283c78
The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes
Wei, Michael, Ong, Leslie, Smith, Maree, Ross, Fraser B., Schmid, Katrina, Hoey, Andrew, Burstow, Darryl and Brown, Lindsay. 2003. "The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes." Heart Lung and Circulation. 12 (1), pp. 44-50. https://doi.org/10.1046/j.1444-2892.2003.00160.x
Long-term administration of pirfenidone improves cardiac function in mdx mice
van Erp, Christel, Irwin, Nicole G. and Hoey, Andrew J.. 2006. "Long-term administration of pirfenidone improves cardiac function in mdx mice." Muscle and Nerve. 34 (3), pp. 327-334. https://doi.org/10.1002/mus.20590
Attenuation of Cardiovascular Remodeling in DOCA-Salt Rats by the Vasopeptidase Inhibitor, Omapatrilat
Loch, David, Hoey, Andrew and Brown, Lindsay. 2006. "Attenuation of Cardiovascular Remodeling in DOCA-Salt Rats by the Vasopeptidase Inhibitor, Omapatrilat ." Clinical and Experimental Hypertension. 28 (5), pp. 475-488. https://doi.org/10.1080/10641960600798754
Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle
Woolf, Peter James, Lu, Sai, Cornford-Nairn, Renee A., Watson, Michael, Xiao, Xiao-Hui, Holroyd, Sean, Brown, Lindsay and Hoey, Andrew. 2006. "Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle." American Journal of Physiology: Heart and Circulatory Physiology. 290 (6), pp. H2439-H2445. https://doi.org/10.1152/ajpheart.00844.2005
Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats
Levick, Scott, Loch, David, Rolfe, Barbara E., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay. 2006. "Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats ." Journal of Immunology. 176 (11), pp. 7000-7007.
Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats
Chan, Vincent, Fenning, Andrew, Levick, Scott P., Loch, David, Chunduri, Prasad, Iyer, Abishek, Teo, Yi Ling, Hoey, Andrew, Wilson, Kathleen, Burstow, Darryl and Brown, Lindsay. 2011. "Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats." Journal of Cardiovascular Pharmacology. 57 (4), pp. 469-478. https://doi.org/10.1097/FJC.0b013e3182102c3b
Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats
Chan, Vincent, Fenning, Andrew, Iyer, Abishek, Hoey, Andrew and Brown, Lindsay. 2011. "Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats." Current Pharmaceutical Biotechnology. 12 (3), pp. 429-436. https://doi.org/10.2174/138920111794480552
Influence of intensive cycling training on heart rate variability during rest and exercise
Leicht, Anthony S., Allen, Graham D. and Hoey, Andrew. 2003. "Influence of intensive cycling training on heart rate variability during rest and exercise." Canadian Journal of Applied Physiology. 28 (6), pp. 898-909.
Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat
Campbell, Fiona, Atwell, Rick, Fenning, Andrew, Hoey, Andrew and Brown, Lindsay. 2004. "Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat." Toxicon. 43 (7), pp. 743-750. https://doi.org/10.1016/j.toxicon.2004.02.025
Rosuvastatin attenuates heart failure and cardiac remodelling in the ageing spontaneously hypertensive rat
Loch, David, Chan, Vincent, Hoey, Andrew and Brown, Lindsay. 2009. "Rosuvastatin attenuates heart failure and cardiac remodelling in the ageing spontaneously hypertensive rat." Basic and Clinical Pharmacology and Toxicology. 105 (4), pp. 262-270. https://doi.org/10.1111/j.1742-7843.2009.00440.x
A novel and simple method for genotyping the mdx mouse using high-resolution melt polymerase chain reaction
Trebbin, Andrea L. and Hoey, Andrew J.. 2009. "A novel and simple method for genotyping the mdx mouse using high-resolution melt polymerase chain reaction." Muscle and Nerve. 39 (5), pp. 603-608. https://doi.org/10.1002/mus.21215
Long-term administration of antisense oligonucleotides into the paraspinal muscles of mdx mice reduces kyphosis
Laws, Nicola, Cornford-Nairn, Renee A., Irwin, Nicole, Johnsen, Russell, Fletcher, Susan, Wilton, Stephen D. and Hoey, Andrew J.. 2008. "Long-term administration of antisense oligonucleotides into the paraspinal muscles of mdx mice reduces kyphosis." Journal of Applied Physiology. 105 (2), pp. 662-668. https://doi.org/10.1152/japplphysiol.00068.2008
Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase
Loch, David, Hoey, Andrew, Morisseau, Christophe, Hammock, Bruce O. and Brown, Lindsay. 2007. "Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase." Cell Biochemistry and Biophysics. 47 (1), pp. 87-98.
Alterations in cardiac dihydropyridine receptors and calcium channel function in MDX mice
Xiao, Xiao-Hui, Woolf, Peter, Watson, Michael, Lu, Sai and Hoey, Andrew. 2004. "Alterations in cardiac dihydropyridine receptors and calcium channel function in MDX mice." Walsh, R. (ed.) ISHR 2004: 18th World Congress of the International Society for Heart Research. Brisbane, Australia 07 - 11 Aug 2004 United Kingdom. https://doi.org/10.1016/j.yjmcc.2004.05.003
Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats
Loch, David, Levick, Scott, Hoey, Andrew and Brown, Lindsay. 2006. "Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats." Journal of Cardiovascular Pharmacology. 47 (3), pp. 396-404.
Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats
Chan, Vincent, Hoey, Andrew and Brown, Lindsay. 2006. "Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats." British Journal of Pharmacology. 148 (7), pp. 902-908. https://doi.org/10.1038/sj.bjp.0706801
Influence of age and moderate-intensity exercise training on heart rate variability in young and mature adults
Leicht, Anthony S., Allen, Graham D. and Hoey, Andrew. 2003. "Influence of age and moderate-intensity exercise training on heart rate variability in young and mature adults." Canadian Journal of Applied Physiology. 28 (3), pp. 446-461.
Progression of kyphosis in mdx mice
Laws, Nicola and Hoey, Andrew. 2004. "Progression of kyphosis in mdx mice." Journal of Applied Physiology. 97 (5), pp. 1970-1977. https://doi.org/10.1152/japplphysiol.01357.2003
Altered contractile, electrophysiological and CA2+ release from left atria and isolated ventricular myocytes from MDX mice
Marrett, Garth, Laws, Nicola, Watson, Michael and Hoey, Andrew. 2006. "Altered contractile, electrophysiological and CA2+ release from left atria and isolated ventricular myocytes from MDX mice." Crane, Denis and Monteith, Greg (ed.) AuPS Conference (2006). Brisbane, Australia 24 - 28 Sep 2006 Australia.
Modifying function and fibrosis of cardiac and skeletal muscle from mdx mice
van Erp, Christel. 2005. Modifying function and fibrosis of cardiac and skeletal muscle from mdx mice. PhD Thesis Doctor of Philosophy. University of Southern Queensland.
Effect of L-arginine on cardiac function and fibrosis in mdx mice
Hoey, Andrew and van Erp, Christel. 2006. "Effect of L-arginine on cardiac function and fibrosis in mdx mice." Crane, Denis and Monteith, Greg (ed.) Combined ASBMB, ASPS, AuPS, ANZSCDB, NZSBMB, NZSPP (2006). Brisbane, Australia 24 - 28 Sep 2006 Australia.
L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats
Fenning, Andrew, Harrison, Glenn, Rose'Meyer, Roselyn, Hoey, Andrew and Brown, Lindsay. 2005. "L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats." American Journal of Physiology: Heart and Circulatory Physiology. 289 (4), pp. H1408-H1416. https://doi.org/10.1152/ajpheart.00140.2005
Reversal of cardiac dysfunction by selective ET-A receptor antagonism
Allan, Anthony, Fenning, Andrew, Levick, Scott, Hoey, Andrew and Brown, Lindsay. 2005. "Reversal of cardiac dysfunction by selective ET-A receptor antagonism." British Journal of Pharmacology. 146 (6), pp. 846-853. https://doi.org/10.1038/sj.bjp.0706384