Chronic b-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat
Article
Article Title | Chronic b-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat |
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ERA Journal ID | 14789 |
Article Category | Article |
Authors | Chan, Vincent (Author), Fenning, Andrew (Author), Hoey, Andrew (Author) and Brown, Lindsay (Author) |
Journal Title | Journal of Cardiovascular Pharmacology |
Journal Citation | 58 (4), pp. 424-431 |
Number of Pages | 8 |
Year | 2011 |
Place of Publication | Philadelphia, PA. United States |
ISSN | 0160-2446 |
1533-4023 | |
Digital Object Identifier (DOI) | https://doi.org/10.1097/FJC.0b013e3182283c78 |
Abstract | Selective β1-adrenoceptor antagonists are part of standard therapy to prolong survival in human heart failure. This study has measured structural, functional, and electrical changes in the cardiovascular system of aging male spontaneously hypertensive rats (SHRs) to determine whether β1-adrenoceptor antagonist treatment can prevent or reverse the development of cardiovascular remodeling and heart failure in these rats. Fifteen-month-old male Wistar-Kyoto (WKY) rats or SHRs were treated with increasing metoprolol doses (30 mg·kg·d for 4 weeks, then 50 mg·kg·d for 4 weeks, then 80 mg·kg·d for 16 weeks po). Cardiovascular structure and function were determined using organ wet weight, in vivo echocardiography, histological analysis of inflammation and collagen, isolated heart and thoracic aortic ring preparations, and single cell microelectrode measurements. From 15 months, untreated SHRs developed left ventricular dilation, hypertrophy, inflammatory cell infiltration and fibrosis, and action potential prolongation together with progressive systolic, diastolic, and endothelial dysfunction and increased cardiac stiffness. Treatment with metoprolol decreased systolic blood pressure at 21 months only but improved survival, decreased ventricular weight, prevented chamber dilation, reduced inflammation, decreased fibrosis, attenuated action potential prolongation, improved systolic and diastolic function, decreased stiffness and improved endothelium-independent vascular responses. Chronic metoprolol treatment markedly attenuated both cardiac and vascular remodeling in the aging SHRs, thus attenuating the onset of heart failure and improving survival, independent of blood pressure reduction. |
Keywords | β-adrenoceptor antagonist; heart failure; hypertension; hypertensive rats; remodeling; spontaneously |
ANZSRC Field of Research 2020 | 310999. Zoology not elsewhere classified |
310910. Animal physiology - systems | |
320101. Cardiology (incl. cardiovascular diseases) | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Department of Biological and Physical Sciences |
University of Queensland | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q0yx0/chronic-b-adrenoceptor-antagonist-treatment-controls-cardiovascular-remodeling-in-heart-failure-in-the-aging-spontaneously-hypertensive-rat
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