Long-term administration of antisense oligonucleotides into the paraspinal muscles of mdx mice reduces kyphosis
Article
Article Title | Long-term administration of antisense oligonucleotides into the paraspinal muscles of mdx mice reduces kyphosis |
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ERA Journal ID | 3161 |
Article Category | Article |
Authors | Laws, Nicola (Author), Cornford-Nairn, Renee A. (Author), Irwin, Nicole (Author), Johnsen, Russell (Author), Fletcher, Susan (Author), Wilton, Stephen D. (Author) and Hoey, Andrew J. (Author) |
Journal Title | Journal of Applied Physiology |
Journal Citation | 105 (2), pp. 662-668 |
Number of Pages | 7 |
Year | 2008 |
Publisher | American Physiological Society |
Place of Publication | United States |
ISSN | 1522-1601 |
8750-7587 | |
Digital Object Identifier (DOI) | https://doi.org/10.1152/japplphysiol.00068.2008 |
Abstract | The mdx mouse model of muscular dystrophy has a premature stop codon preventing production of dystrophin. This results in a progressive phenotype causing centronucleation of skeletal muscle fibers, muscle weakness and fibrosis and kyphosis. Antisense oligonucleotides alter RNA splicing to exclude the nonsense mutation, while still maintaining the open reading frame to produce a shorter, but partially functional dystrophin protein that should ameliorate the extent of pathology. The present study investigated the benefits of chronic treatment of mdx mice by once-monthly deep intramuscular injections of antisense oligonucleotides into paraspinal muscles. After 8 |
Keywords | duchenne muscular dystrophy; exon skipping; mdx mouse |
ANZSRC Field of Research 2020 | 320905. Neurology and neuromuscular diseases |
320601. Gene and molecular therapy | |
321401. Basic pharmacology | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Centre for Systems Biology |
University of Western Australia |
https://research.usq.edu.au/item/9yzv1/long-term-administration-of-antisense-oligonucleotides-into-the-paraspinal-muscles-of-mdx-mice-reduces-kyphosis
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