Defective entities and uses therefor

Patent

Cornford-Nairn, Renee, Daggard, Grant Edward, Mukkur, Trilochan Kanwaljit Singh and Rossetti, Tony Robert. 2008. Defective entities and uses therefor. AU2002357406
Title

Defective entities and uses therefor

TypePatent
AuthorsCornford-Nairn, Renee (Author), Daggard, Grant Edward (Author), Mukkur, Trilochan Kanwaljit Singh (Author) and Rossetti, Tony Robert (Author)
Patent/Trademark ApplicantMukkur, Trilochan Kanwaljit Singh
Patent/Trademark NumberAU2002357406
Countries in Which Patented/TrademarkedUnited States of America
Number of Pages46
Year2008
Web Address (URL)http://www.google.com/patents/US20050238657
http://www.patentbuddy.com/Patent/20050238657?downloadPdf=true
Abstract

The present invention discloses the structure and sequence of aroQ from Bordetella pertussis, which are useful inter alia for the production of the genetically modified attenuated Bordetella strains of the present invention and for detecting and isolating variant aroQ genes and expression products. The present invention also discloses attenuated Bordetella strains of pathogenic origin, and more particularly genetically modified Bordetella strains, which have been attenuated by disruption or inactivation of the aroQ gene. The genetically modified Bordetella strain of the present invention has a reduced capacity to propagate in a mammalian host, but remains viable in the host for a period of time sufficient to induce a protective immune response against the natural pathogenic Bordetella counterpart. The present invention is also directed to the use of such genetically modified Bordetella strains in immunopotentiating compositions for treating and/or preventing inter alia Bordetella infections, and particularly pathogenic infections, caused by Bordetella.

Keywordswhooping cough; coccobacillus; bacterium; airborne droplets; respiratory infection
ANZSRC Field of Research 2020320602. Medical biotechnology diagnostics (incl. biosensors)
320103. Respiratory diseases
320701. Medical bacteriology
Public Notes

This publication is copyright. It may be reproduced in whole or in part for the purposes of study, research, or review, but is subject to the inclusion of an acknowledgment of the source.

Byline AffiliationsDepartment of Biological and Physical Sciences
Institution of OriginUniversity of Southern Queensland
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