The correlation between the mutation of protein kinase genes and the clinical characteristics of breast cancer progression
Poster
Paper/Presentation Title | The correlation between the mutation of protein kinase genes and the clinical characteristics of breast cancer progression |
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Presentation Type | Poster |
Authors | Birney, Genevieve (Author), Liu, Guang B. (Author) and Daggard, Grant (Author) |
Year | 2010 |
Place of Publication | St. Lucia, Australia |
Web Address (URL) of Paper | http://www.asmr.org.au/MRWQld.html |
Conference/Event | ASMR Queensland Postgraduate Student Conference 2010 |
Event Details | ASMR Queensland Postgraduate Student Conference 2010 Event Date 02 Jun 2010 Event Location St Lucia, Australia |
Abstract | It is accepted that breast cancer (BC) is a heterogeneous disease. In order to investigate BC as a group of disease sub-types, the varying clinical characteristics of BC patients must be considered. In this project a series of clinical, pathological, genetic and genomic data, retrieved from multiple data repositories, will be reviewed for selection in a large-scale meta-analysis and then categorised into 5 sub-groups (Luminal A, Luminal B, Basal, HER2 and Normal). The meta-analysis is primarily designed to ascertain if a correlation exists between the mutation of protein kinase (PK) genes and BC progression. As PK genes play important roles in regulating most cellular processes (e.g. cell proliferation, differentiation and apoptosis), it is no surprise that deregulated PK activity is a frequent cause of disease, and that PK genes are often oncogenes. The meta-analysis objectives are two-fold: |
Keywords | breast cancer; protein kinase genes; mutation; correlation |
ANZSRC Field of Research 2020 | 310114. Systems biology |
310299. Bioinformatics and computational biology not elsewhere classified | |
310505. Gene expression (incl. microarray and other genome-wide approaches) | |
Public Notes | Only abstracts published in the conference proceedings, as supplied here. |
Byline Affiliations | Department of Biological and Physical Sciences |
https://research.usq.edu.au/item/q0187/the-correlation-between-the-mutation-of-protein-kinase-genes-and-the-clinical-characteristics-of-breast-cancer-progression
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