Development of a binocular rivalry testing system for large-scale psychiatric and genetic studies

Presentation

Law, P. C. F., Paton, B., Liu, G. B., Ngo, T. T. and Miller, S. M.. 2011. "Development of a binocular rivalry testing system for large-scale psychiatric and genetic studies." 1st Scientific Meeting of Biological Psychiatry Australia. Melbourne, Australia 07 - 08 Nov 2011 Melbourne, Australia.
Paper/Presentation Title

Development of a binocular rivalry testing system for large-scale psychiatric and genetic studies

Presentation TypePresentation
AuthorsLaw, P. C. F. (Author), Paton, B. (Author), Liu, G. B. (Author), Ngo, T. T. (Author) and Miller, S. M. (Author)
Journal or Proceedings TitleProceedings of the 1st Scientific Meeting of Biological Psychiatry Australia
Number of Pages1
Year2011
Place of PublicationMelbourne, Australia
Web Address (URL) of Paperhttp://www.biolpsychaustralia.com.au/wp-content/themes/netwiz-biol/pdf/proceeding-BPA.pdf
Conference/Event1st Scientific Meeting of Biological Psychiatry Australia
Event Details
1st Scientific Meeting of Biological Psychiatry Australia
Event Date
07 to end of 08 Nov 2011
Event Location
Melbourne, Australia
Abstract

Introduction: When different stimuli are presented simultaneously, one to each eye, perceptual alternations occur between each image every few seconds. Such binocular rivalry (BR) has intrigued vision scientists for nearly two centuries and the methods by which BR is presented (usually in small-scale studies) have been mostly confined to expert psychophysicists. It has been demonstrated that BR rate is
slow in bipolar disorder (BD) [1], a psychiatric condition with high heritability. It has also been shown that BR rate is itself around 50% heritable [2]. These findings have led to establishment of a large-scale multicentre consortium to investigate slow BR rate as an endophenotype for BD [3]. Methods: We describe the development of a prototype, user-friendly BR testing system for use in such large-scale studies and for operation by non-specialised research staff. The system is currently operational, or is in the process of being installed, at the following sites: Monash Alfred Psychiatry Research Centre (P.B. Fitzgerald), The
Geelong Clinic (M. Berk), UNSW (P.B. Mitchell), Cade Clinic (G.S. Malhi), Queensland Institute of Medical Research (N.G. Martin & M.J. Wright), Royal Brisbane & Women’s Hospital (J.G. Scott), Cardiff University (D.J. Smith), and University of Göttingen (T.G. Schulze).
Results: The BR system consists of a PC with enhanced PSU capability and an Eyefinity-enabled video card, which is connected to both a conventional monitor (for data collection/analysis via a single GUI) and a specialised True3Di™ monitor for stimulus presentation. The system also has an accompanying manual which provides step-by-step details of the entire testing procedure.
Conclusions: We have developed a BR testing system that is well suited to largescale psychiatric genetic studies and use by non-specialised research staff. Its ease of operation will facilitate new groups joining the national/international consortium, thus enabling the large Ns required for endophenotype-based GWAS of BR and BD.

Keywordsendophenotype; bipolar disorder; binocular rivalry
ANZSRC Field of Research 2020320907. Sensory systems
320221. Psychiatry (incl. psychotherapy)
320602. Medical biotechnology diagnostics (incl. biosensors)
Public Notes

Abstract only, as displayed here, published in Conference Proceedings.

Byline AffiliationsMonash University
Centre for Systems Biology
Department of Biological and Physical Sciences
Institution of OriginUniversity of Southern Queensland
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