Modulating the rate and rhythmicity of perceptual rivalry alternations with the mixed 5-HT2A and 5-HT1A agonist psilocybin

Article

Carter, Olivia L., Pettigrew, John D., Hasler, Felix, Wallis, Guy M., Liu, Guang B., Hell, Daniel and Vollenweider, Franz X.. 2005. "Modulating the rate and rhythmicity of perceptual rivalry alternations with the mixed 5-HT2A and 5-HT1A agonist psilocybin." Neuropsychopharmacology. 30 (6), pp. 1154-1162. https://doi.org/10.1038/sj.npp.1300621
Article Title

Modulating the rate and rhythmicity of perceptual rivalry alternations with the mixed 5-HT2A and 5-HT1A agonist psilocybin

ERA Journal ID40224
Article CategoryArticle
AuthorsCarter, Olivia L. (Author), Pettigrew, John D. (Author), Hasler, Felix (Author), Wallis, Guy M. (Author), Liu, Guang B. (Author), Hell, Daniel (Author) and Vollenweider, Franz X. (Author)
Journal TitleNeuropsychopharmacology
Journal Citation30 (6), pp. 1154-1162
Number of Pages8
Year2005
Place of PublicationUnited Kingdom
ISSN0893-133X
1740-634X
Digital Object Identifier (DOI)https://doi.org/10.1038/sj.npp.1300621
Web Address (URL)http://www.nature.com/npp/journal/v30/n6/pdf/1300621a.pdf
Abstract

Binocular rivalry occurs when different images are presented simultaneously to corresponding points within the left and right eyes. Under these conditions, the observer’s perception will alternate between the two perceptual alternatives. Motivated by the reported link
between the rate of perceptual alternations, symptoms of psychosis and an incidental observation that the rhythmicity of perceptual alternations during binocular rivalry was greatly increased 10 h after the consumption of LSD, this study aimed to investigate the pharmacology underlying binocular rivalry and to explore the connection between the timing of perceptual switching and psychosis.
Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine, PY) was chosen for the study because, like LSD, it is known to act as an agonist at serotonin (5-HT)1A and 5-HT2A receptors and to produce an altered state sometimes marked by psychosis-like symptoms. A total of 12 healthy human volunteers were tested under placebo, low-dose (115 mg/kg) and high-dose (250 mg/kg) PY conditions. In line with
predictions, under both low- and high-dose conditions, the results show that at 90 min postadministration (the peak of drug action), rate and rhythmicity of perceptual alternations were significantly reduced from placebo levels. Following the 90 min testing period, the
perceptual switch rate successively increased, with some individuals showing increases well beyond pretest levels at the final testing, 360 min postadministration. However, as some subjects had still not returned to pretest levels by this time, the mean phase duration at 360 min was not found to differ significantly from placebo. Reflecting the drug-induced changes in rivalry phase durations, subjects
showed clear changes in psychological state as indexed by the 5D-ASC (altered states of consciousness) rating scales. This study suggests the involvement of serotonergic pathways in binocular rivalry and supports the previously proposed role of a brainstem oscillator in
perceptual rivalry alternations and symptoms of psychosis.

Keywordsbinocular rivalry
ANZSRC Field of Research 2020321402. Clinical pharmacology and therapeutics
420313. Mental health services
Public Notes

File reproduced in accordance with the copyright policy of the publisher/author.

Byline AffiliationsUniversity of Queensland
Heffter Research Centre Zurich, Switzerland
University Hospital of Psychiatry, Switzerland
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