Bioinformatic analysis indicates a relationship between CpG islands & nuclear protein function, as well as a Stop Codon Usage Bias

Poster

Berkman, Paul and Liu, Guang Bin. 2008. "Bioinformatic analysis indicates a relationship between CpG islands & nuclear protein function, as well as a Stop Codon Usage Bias." Bioinformatics Australia Conference (2008). Gold Coast, Queensland 01 - 03 Dec 2008 Gold Coast, Australia.
Paper/Presentation Title

Bioinformatic analysis indicates a relationship between CpG islands & nuclear protein function, as well as a Stop Codon Usage Bias

Presentation TypePoster
AuthorsBerkman, Paul (Author) and Liu, Guang Bin (Author)
Journal or Proceedings TitleBioinformatics Australia Conference 2008
Number of Pages2
Year2008
Place of PublicationGold Coast, Australia
Web Address (URL) of Paperhttp://mlaa.com.au/giw2008/PDFposter/giw2008poster_submission_5.pdf
Conference/EventBioinformatics Australia Conference (2008)
Event Details
Bioinformatics Australia Conference (2008)
Event Date
01 to end of 03 Dec 2008
Event Location
Gold Coast, Queensland
Abstract

CpG islands (CGI) are associated with gene regulation with unknown mechanism of expression, though it has been over 20 years since their initial identification. This study was conducted to grasp the importance of CGIs and their distribution in human chromosome 1, and from this to further characterise how they relate to gene expression in the human genome. Analysing the distribution of CGIs and core promoter regulatory elements in promoter region of the genes on human chromosome 1 contributes a greater understanding of the types of genes with which CGIs are associated. The trends in protein localisation and function with the variation of CpG island density in the genes on human chromosome 1 suggest that genes with a CpG island in the promoter region significantly more frequently produce proteins that are located in the cytoplasm, nucleus, and nucleolus, and less frequently in the plasma membrane. As well as this, it is indicated high density CpG islands are more frequently related to genes with protein products localised significantly more in the nucleus and with likely DNA binding function. The relationship between CpG islands and core promoter elements in human chromosome 1 support a relationship between CpG islands and the GC box that may have transcriptional significance for the function of CpG islands.

ANZSRC Field of Research 2020310508. Genome structure and regulation
310299. Bioinformatics and computational biology not elsewhere classified
Byline AffiliationsCentre for Systems Biology
Department of Biological and Physical Sciences
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