Structural and functional characteristics of the promoter regions of the genes on human chromosome 22

Poster

Liu, Guang Bin. 2007. "Structural and functional characteristics of the promoter regions of the genes on human chromosome 22." 5th Asia-Pacific Bioinformatics Conference (APBC2007). Hong Kong, China 15 - 17 Jan 2007 Hong Kong.
Paper/Presentation Title

Structural and functional characteristics of the promoter regions of the genes on human chromosome 22

Presentation TypePoster
Authors
AuthorLiu, Guang Bin
Journal or Proceedings TitleProceedings of the 5th Asia-Pacific Bioinformatics Conference, APBC2007
Number of Pages1
Year2007
Place of PublicationHong Kong
Web Address (URL) of Paperhttp://www.cs.hku.hk/apbc2007/index.htm
Conference/Event5th Asia-Pacific Bioinformatics Conference (APBC2007)
Event Details
5th Asia-Pacific Bioinformatics Conference (APBC2007)
Event Date
15 to end of 17 Jan 2007
Event Location
Hong Kong, China
Abstract

The base composition pattern in the putative promoter region (PPRs) up to 5 Kb lengths of 682 human genes on Chromosome 22 (Chr22) was examined. Two-dimensional (2-D) and three-dimensional (2-D) functions were designed to delineate the DNA base composition, with four major patterns identified. It is found that 17.6% genes include TATA box, 28.0% GC box, 18.9% CAAT box and 38.4% CpG islands, and approximately 10 % genes have one of four putative initiator motifs. The occurrence of the promoter elements is tightly associated with the base composition features in the promoter regions, and the associations of the base composition features with occurrence of the promoter elements in the promoter regions mediate tissue-wide expression of the genes in human. The occurrence of two or more promoter elements in the promoter regions is required for the medium- and wide-range expression profiles of the human genes on Chr22. Thus, the reported data shed light on the characteristics of the PPRs of the human genes on Chr22, which may improve our understanding of regulatory roles of the PPRs with occurrence of the promoter elements in gene expression.

Keywordsgenetics; chromosome 22; human DNA
ANZSRC Field of Research 2020310508. Genome structure and regulation
310299. Bioinformatics and computational biology not elsewhere classified
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Byline AffiliationsDepartment of Biological and Physical Sciences
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